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Metadona

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Metadona uses and description

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Metadona - Used for: Treating moderate to severe pain that is not relieved by other pain medicines. It is also used in treating narcotic addiction as part of a treatment program. It may also be used for other conditions as determined by your doctor.

Metadona is a narcotic analgesic. It works by acting on opiate pain receptors in the brain and on smooth muscle to provide pain relief.

Metadona is a synthetic opioid analgesic with multiple actions quantitatively similar to those at morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, Metadona is more active and more toxic than morphine. Metadona is indicated for relief of severe pain, for detoxification treatment of narcotic addiction, and for temporary maintenance treatment of narcotic addiction. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. The Metadona abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.

Oral Analgesia

Adult: Initially 2.5-10 mg every 6-8 hr as required. Titrate dose slowly and according to response. May also be given via IM or SC inj. Not more than twice daily dosing for prolonged use.

Child: 0.7 mg/kg/day in divided doses every 4-6 hr as required, max 10 mg/dose. Dose should be titrated carefully according to individual requirements. Hepatic impairment: Dosage may need to be reduced. Oral Opioid dependence

Adult: Initial dose of 20-30 mg as a single dose. Additional doses of 5-10 mg may be used if withdrawal symptoms are not suppressed or if they reappear. Total dose should not exceed 40 mg on the 1st day. Usual stabilising dose: 40 mg daily in single or divided doses. Once patient has stabilised for 2 or 3 days, dosage may be gradually reduced daily or at 2-day intervals. Dosage must be individualised and adjusted to keep withdrawal symptoms at a tolerable level.

Child: Dose should be individualised according to opiate tolerance. After a period of maintenance treatment, withdrawal should be slow, with doses reduced by <10% at a time with 10-14 day intervals between dose reductions. Hepatic impairment: Dosage may need to be reduced. Oral Neonatal abstinence syndrome

Child: 100 mcg/kg increased by 50 mcg/kg every 6 hr until symptoms are controlled. Daily dose should be given in 2 divided doses during prolonged use. Hepatic impairment: Dosage may need to be reduced. Oral Intractable cough associated with lung cancer

Adult: 1-2 mg every 4-6 hr. Reduce to 12 hrly during prolonged use. Hepatic impairment: Dosage may need to be reduced.

Indications:

Adult: PO Analgesia Initial: 2.5-10 mg 6-8 hrly if needed. Opioid dependence Iniividualise dose according to opiate tolerance. Usual regimen: Initial: 20-30 mg as a single dose. Additional doses of 5-10 mg may be used if withdrawal symptoms are not suppressed or if they reappear. Max: 40 mg on the 1st day. Usual stabilising dose: 40 mg/day in single or divided doses. Once patient has stabilised, reduce dosage gradually. Dosage must be individualised. Intractable cough associated with lung cancer 1-2 mg 4-6 hrly, reduce to 12 hrly for prolonged use.

Oral Analgesia

Adult: Initially 2.5-10 mg every 6-8 hr as required. Titrate dose slowly and according to response. May also be given via IM or SC inj. Not more than twice daily dosing for prolonged use.

Child: 0.7 mg/kg/day in divided doses every 4-6 hr as required, max 10 mg/dose. Dose should be titrated carefully according to individual requirements. Hepatic impairment: Dosage may need to be reduced. Oral Opioid dependence

Adult: Initial dose of 20-30 mg as a single dose. Additional doses of 5-10 mg may be used if withdrawal symptoms are not suppressed or if they reappear. Total dose should not exceed 40 mg on the 1st day. Usual stabilising dose: 40 mg daily in single or divided doses. Once patient has stabilised for 2 or 3 days, dosage may be gradually reduced daily or at 2-day intervals. Dosage must be individualised and adjusted to keep withdrawal symptoms at a tolerable level.

Child: Dose should be individualised according to opiate tolerance. After a period of maintenance treatment, withdrawal should be slow, with doses reduced by <10% at a time with 10-14 day intervals between dose reductions. Hepatic impairment: Dosage may need to be reduced. Oral Neonatal abstinence syndrome

Child: 100 mcg/kg increased by 50 mcg/kg every 6 hr until symptoms are controlled. Daily dose should be given in 2 divided doses during prolonged use. Hepatic impairment: Dosage may need to be reduced. Oral Intractable cough associated with lung cancer

Adult: 1-2 mg every 4-6 hr. Reduce to 12 hrly during prolonged use. Hepatic impairment: Dosage may need to be reduced. Special Populations: Creatinine clearance < 10 mL/min: 50-75% of normal dose; if severe renal failure, avoid use. For patients with liver disease, reduce dose and avoid in severe liver impairment.

Metadona is a narcotic pain reliever, similar to morphine. It also reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the "high" associated with the drug addiction. Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs.

Active ingredients: Methadone
Unit description, dosagePrice, USD
Injectable; Injection; Methadone Hydrochloride 5 mg / ml

List of metadona brand and generic drugs

Metadon-EP (Hungary)
Metadona Clorhidrato (Chile)
Metadona Clorhidrato Sanderson (Chile)
Metadone Cloridrato (Georgia)
Metadone Cloridrato Afom (Italy)
Metadone Cloridrato Molteni (Georgia, Italy)
Metadonijev Klorid (Slovenia)
Metasedin
Meth
Methaddict (Luxembourg)
Methadon
Drops; Oral; Methadone Hydrochloride 10 mg / ml
Drops; Oral; Methadone Hydrochloride 20 mg / ml
Drops; Oral; Methadone Hydrochloride 50 mg / ml
Injectable; Injection; Methadone Hydrochloride 10 mg / ml
Suppositories; Rectal; Methadone Hydrochloride 10 mg
Tablet; Oral; Methadone Hydrochloride 5 mg
Methadon Alternova (Denmark)
Methadon HCL (Netherlands)
Methadon Regenboog (Netherlands)
Methadon Sintetica (Switzerland)
Methadon Streuli (Switzerland)
Methadon Tiofarma (Netherlands)
Methadone (Denmark)
Tablet; Oral; Methadone Hydrochloride 5 mg
Tablet; Oral; Methadone Hydrochloride 10 mg
Tablet; Oral; Methadone Hydrochloride 40 mg
Concentrate; Oral; Methadone Hydrochloride 1%
Concentrate; Oral; Methadone Hydrochloride 2%
Injectable; Injection; Methadone Hydrochloride 1%
Solution; Oral; Methadone Hydrochloride 0.1%
Powder; for Rx Compounding; Methadone Hydrochloride 100 g
Powder; for Rx Compounding; Methadone Hydrochloride 500 g
Powder; for Rx Compounding; Methadone Hydrochloride 50 g
Concentrate; Oral; Methadone Hydrochloride 10 mg / ml
Solution; Oral; Methadone Hydrochloride 5 mg / 5 ml
Solution; Oral; Methadone Hydrochloride 10 mg / 5 ml
Solution; Oral; Methadone Hydrochloride 5%
Syrup; Oral; Methadone Hydrochloride 5 mg / ml
Methadone hcl 10 mg/ml vial$ 7.48
Methadone hcl powder$ 5.91
Metadol 25 mg Tablet$ 1.69
Metadol 10 mg Tablet$ 0.90
Methadone intensol 10 mg/ml$ 0.85

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