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Monocillin

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Monocillin uses and description

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Monocillin - Monocillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Monocillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Monocillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Indication: For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.

Parenteral Susceptible infections

Adult: 0.6-4.8 g/day in 2-4 divided doses via IM, slow IV inj or infusion, higher doses may be needed in more serious infections. IV doses >1.2 g should be given at a rate of not >300 mg/minute.

Child: 1 mth-12 yr: 100 mg/kg daily in 4 divided doses. Infant 1-4 wk: 75 mg/kg daily in 3 divided doses. Premature infant and neonate up to 7 days old: 50 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Bacterial endocarditis

Adult: 1.2 g every 4 hr by slow inj or infusion, usually used with an aminoglycoside. Renal impairment: Dose adjustments may be necessary. Intravenous Intrapartum prophylaxis against group B Streptoccocal infection in neonates

Adult: Initially, 3 g via IV inj, followed by 1.5 g every 4 hr until delivery.

Child: 150 mg/kg daily in 4 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Meningococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Pneumococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary.

Intravenous Bacterial endocarditis

Adult: 1.2 g every 4 hr by slow inj or infusion, usually used with an aminoglycoside. Renal impairment: Dose adjustments may be necessary. Intravenous Intrapartum prophylaxis against group B Streptoccocal infection in neonates

Adult: Initially, 3 g via IV inj, followed by 1.5 g every 4 hr until delivery.

Child: 150 mg/kg daily in 4 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Meningococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Intravenous Pneumococcal meningitis

Adult: 2.4 g every 4 hr by slow inj or infusion. Up to 18 g/day in meningococcal meningitis. Administer high doses (>1.2 g) at a rate not >300 mg/minute to prevent CNS irritation and electrolyte imbalance.

Child: 1 mth-12 yr: 180-300 mg/kg daily in 4-6 divided doses. Infant 1-4 wk: 150 mg/kg daily in 3 divided doses. Premature infant and neonate: 100 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary. Parenteral Infections due to susceptible organisms

Adult: 0.6-4.8 g/day in 2-4 divided doses via IM, slow IV inj or infusion, higher doses may be needed in more serious infections. IV doses >1.2 g should be given at a rate of not >300 mg/minute.

Child: 1 mth-12 yr: 100 mg/kg daily in 4 divided doses. Infant 1-4 wk: 75 mg/kg daily in 3 divided doses. Premature infant and neonate up to 7 days old: 50 mg/kg daily in 2 divided doses. Renal impairment: Dose adjustments may be necessary.

Active ingredients: Benzylpenicillin
Unit description, dosagePrice, USD

List of monocillin brand and generic drugs

Moldamin (Romania, Tunisia)
Mylipen (United Kingdom)
Natrium-penicilline G (Netherlands)
Neumicin-B (Ethiopia)
Norocillin (Australia, Ireland, Netherlands, New Zealand, United Kingdom)
Injectable; Injection; Penicillin G Procaine 30%
Norocillin LA (Australia, New Zealand, Switzerland)
Noropen (Norway)
Novocillin (Norway)
Ovipen (New Zealand)
P-Benza (Peru)
P.P. (Netherlands)
Pan Peni G (Croatia (Hrvatska))
Pan-Peni G (Serbia)
Pan-Peni G sodium (Serbia)
Pan-Penicillin G (Lithuania)
Pan-Penicillin G sodium (Latvia)
PĂ©nicilline G Panpharma (France)
Pen 30 (Belgium, Netherlands)
Pen BP 48 (United States)
Pen-G (Bangladesh)
Penacare (United Kingdom)
Penadur (Belgium, Ethiopia, Greece, Luxembourg)
Penadur L.A. (Bahrain, Botswana, Cyprus, Egypt, Ghana, Jordan, Kenya, Kuwait, Lebanon, Malawi, Mozambique, Namibia, Nigeria, Philippines, Qatar, Saudi Arabia, Tanzania, Uganda, United Arab Emirates, Yemen, Zimbabwe)
Penalone (New Zealand)
Penaqua (United States)
Pencain-K (Turkey)
Pencom (India)
PENCOM Injection / 12 L. Units (1vial units)$ 0.21
PENCOM Injection / 6 L. Units (1vial units)$ 0.15
600000 u x 1's$ 0.14
1200000 u x 1's$ 0.20
Pencom 600000 u VIAL / 1$ 0.14
Pencom 1200000 u VIAL / 1$ 0.20
Pendepon (Czech Republic, Slovakia)
Pendiben LA (Peru)
Pendysin (Germany)
Pengesod (Mexico)
Peni (South Africa)
Peni G Panpharma (Tunisia)
Peni-Kel (Belgium)
Penibiot (Spain)
Penicilin G (Czech Republic, Slovakia)
Penicilina Benzatinica (Colombia)

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