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Nidesef

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Nidesef uses and description

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Nidesef consists of Gabapentin, Tramadol.

Gabapentin - Used for: Treating nerve pain caused by shingles. It may also be used for other conditions as determined by your doctor.

Nidesef (Gabapentin) is an analgesic for neuropathic (nerve) pain. Exactly how it works to treat nerve pain is not known.

Pharmacology: Mechanism unknown; Nidesef (Gabapentin) enacarbil is a prodrug of gabapentin.

Indication: Adjunctive therapy in treatment of partial seizures with or without secondary generalization in patients older than 12 y with epilepsy (immediate release); adjunctive therapy for partial seizures in children 3 to 12 y of age; management of postherpetic neuralgia in adults (immediate release); treatment of moderate to severe primary restless legs syndrome in adults (ER).

Unlabeled Uses

Agitation in dementia; alcohol withdrawal; bipolar disorder; cocaine withdrawal; diabetic neuropathy; fibromyalgia; headaches; hiccups (singultus); hot flashes (cancer- and/or postmenopausal-related); hyperhidrosis; nausea (cancer-related); neuralgia/neuropathy/chronic pain; prevention of migraine; pruritus (brachioradial/cholestatic/uremic); rectal administration; restless legs syndrome (immediate release); tremors in multiple sclerosis.

Nidesef (Gabapentin) is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Nidesef (Gabapentin) is different from other anticonvulsants acting through GABA synapses (including valproate, barbiturates, benzodiazepines, inhibitors of GABA-transaminase, inhibitors of GABA capture, GABA agonists and prodrugs of GABA). In in vitro studies showed that Nidesef (Gabapentin) is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Nidesef (Gabapentin) and its derivatives. Nidesef (Gabapentin) in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.

The final mechanism of action of Nidesef (Gabapentin) is not defined.

Nidesef (Gabapentin), an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Nidesef (Gabapentin) has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn\'t possess the usual drug interactions.

Nidesef (Gabapentin) is used to treat epilepsy (also known as seizures or fits). It is also used to relieve nerve pain in people with diabetes or shingles. Nidesef (Gabapentin) may also be used to relieve hot flushes in women with breast cancer and in women who have passed menopause.

Oral Epilepsy (partial seizures with or without secondary generalisation)

Adult: Initially, 300 mg on the 1st day, 300 mg bid on the 2nd day and 300 mg tid on the 3rd day. Thereafter, may increase dose until effective antiepileptic control is achieved. Usual maintenance range: 0.9-3.6 g daily; daily dose to be taken in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g daily.

Child: 6-12 yr: Initially, 10 mg/kg on the 1 st day, 20 mg/kg on the 2 nd day and 25-35 mg/kg on the 3 rd day.

Maintenance: 1200 mg daily (37-50 kg); 900 mg daily (26-36 kg). Total daily dose to be taken in 3 equally divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Oral Neuropathic pain

Adult: Titrate to a max of 1.8 g daily in 3 divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days.

Indications:

Adult: PO Epilepsy Initial: 300 mg on the 1st day, 300 mg twice daily on the 2nd day and 300 mg 3 times/day on the 3rd day. Thereafter, may increase dose based on response.

Maintenance: 0.9-3.6 g/day in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g/day. Neuropathic pain Up to a max of 1.8 g/day in 3 divided doses.

Oral Epilepsy

Adult: Initially, 300 mg on the 1st day, 300 mg bid on the 2nd day and 300 mg tid on the 3rd day. Thereafter, may increase dose until effective antiepileptic control is achieved. Usual maintenance range: 0.9-3.6 g daily; daily dose to be taken in 3 equally divided doses and max dosing interval: 12 hr. Max: 4.8 g daily.

Child: 6-12 yr: Initially, 10 mg/kg on the 1 st day, 20 mg/kg on the 2 nd day and 25-35 mg/kg on the 3 rd day.

Maintenance: 1200 mg daily (37-50 kg); 900 mg daily (26-36 kg). Total daily dose to be taken in 3 equally divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Oral Neuropathic pain

Adult: Titrate to a max of 1.8 g daily in 3 divided doses. Renal impairment: Total daily doses to be taken as 3 divided doses. Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) Dosage Recommendation 50-79 600-1200 mg daily. 30-49 300-600 mg daily. 15-29 300 mg on alternate days to 300 mg daily. <15 300 mg on alternate days. Special Populations: Renal impairment: CrCl: 50-79 mL/min: 600-1200 mg daily; 30-49 mL/min: 300-600 mg daily; 15-29 mL/min: 150 mg daily (or 300 mg every other day) to 300 mg daily; <15 mL/min: 150 mg daily (or 300 mg every other day). To be given in 3 divided doses. Recommended loading dose for patients undergoing haemodialysis who have never received gabapentin: 300-400 mg, followed by 200-300 mg after each 4 hr of haemodialysis.

Tramadol - Used for: Treating moderate to moderately severe pain.

Nidesef (Tramadol) is an analgesic. It works in certain areas of the brain and nervous system to decrease pain.

Nidesef (Tramadol) is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Nidesef (Tramadol) is a racemate (+) and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.

Nidesef (Tramadol) causes sedation. At therapeutic doses this medication almost not get respiratory depression. Nidesef (Tramadol) has also an antitussive effect.

Nidesef (Tramadol), a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Nidesef (Tramadol) is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine.

Indications:

Adult: PO Moderate to severe pain 50-100 mg 4-6 hrly. Max: 400 mg/day. Extended-release 50-100 mg 1-2 times/day. Max: 300 mg/day. IV/IM Moderate to severe pain 50-100 mg 4-6 hrly. Post-op pain Initial: 100 mg, then 50 mg every 10-20 mins if needed, up to 250 mg for the 1st hr.

Maintenance: 50-100 mg 4-6 hrly. Max: 600 mg/day. Rectal Moderate to severe pain As 100 mg supp: 1 supp up to 4 times/day.

Oral Moderate to severe pain

Adult: As conventional tablet: 50-100 mg every 4-6 hr. Max: 400 mg daily. As extended-release tablet: 50-100 mg once or twice daily. Max: 300 mg daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). Max

Dosage: 400 mg daily. CrCl (ml/min) Dosage Recommendation 10-<30 As conventional tablet: increase dosage interval to 12 hr; max: 200 mg/day. <10 Contraindicated. Hepatic impairment: As conventional tablet: Increase dosage interval to 12 hr in severe impairment e.g. 50 mg bid in hepatic cirrhosis. As extended-release tablet: Contraindicated in Child Pugh Class C. Parenteral Moderate to severe pain

Adult: IM/IV inj over 2-3 min/IV infusion: 50-100 mg given every 4-6 hr.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation 10-<30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: Increase dosage interval to 12 hr. Parenteral Postoperative pain

Adult: IM/IV inj over 2-3 min/IV infusion: Initially, 100 mg followed by 50 mg every 10-20 min if necessary up to 250 mg for the 1st hr.

Maintenance: 50-100 mg every 4-6 hr. Max: 600 mg daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation 10-<30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: increase dosage interval to 12 hr. Rectal Moderate to severe pain

Adult: 100 mg suppository up to 4 times daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation <30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: Increase dosage interval to 12 hr. Incompatibility: Incompatible with injections of diazepam, diclofenac sodium, indometacin, midazolam, piroxicam, phenylbutazone, aciclovir, clindamycin and lysine aspirin if mixed in the same syringe.

Nidesef (Tramadol) is a painkiller used to treat moderate to severe pain. It is often used to relieve pain after an operation.

Nidesef (Tramadol) is a narcotic-like pain reliever. Nidesef (Tramadol) is used to treat moderate to severe pain. Nidesef (Tramadol) extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Oral Moderate to severe pain

Adult: As conventional tablet: 50-100 mg every 4-6 hr. Max: 400 mg daily. As extended-release tablet: 50-100 mg once or twice daily. Max: 300 mg daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). Max

Dosage: 400 mg daily. CrCl (ml/min) Dosage Recommendation 10-<30 As conventional tablet: increase dosage interval to 12 hr; max: 200 mg/day. <10 Contraindicated. Hepatic impairment: As conventional tablet: Increase dosage interval to 12 hr in severe impairment e.g. 50 mg bid in hepatic cirrhosis. As extended-release tablet: Contraindicated in Child Pugh Class C. Parenteral Moderate to severe pain

Adult: IM/IV inj over 2-3 min/IV infusion: 50-100 mg given every 4-6 hr.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation 10-<30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: Increase dosage interval to 12 hr. Parenteral Postoperative pain

Adult: IM/IV inj over 2-3 min/IV infusion: Initially, 100 mg followed by 50 mg every 10-20 min if necessary up to 250 mg for the 1st hr.

Maintenance: 50-100 mg every 4-6 hr. Max: 600 mg daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation 10-<30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: increase dosage interval to 12 hr. Rectal Moderate to severe pain

Adult: 100 mg suppository up to 4 times daily.

Elderly: Lower initial dose. Max: 300 mg daily (>75 yr). CrCl (ml/min) Dosage Recommendation <30 Increase dosage interval to 12 hr. <10 Contraindicated. Hepatic impairment: Severe: Increase dosage interval to 12 hr. Special Populations: A dosage interval of 12 hrs is recommended in severe hepatic impairment. Incompatibility: Incompatible with injections of diazepam, diclofenac sodium, indometacin, midazolam, piroxicam, phenylbutazone, aciclovir, clindamycin and lysine aspirin if mixed in the same syringe.

Indications: Analgesic and antipyretic.

Indications: Symptomatic relief of acute nausea and vomiting.

Gastric motility disorders such as reflux oesophagitis and duodenogastric dyspeptic symptoms.

Active ingredients: Gabapentin/Tramadol
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