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Nipresol

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Nipresol uses and description

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Nipresol - Pharmacology: Blocks beta receptors, primarily affecting CV system (decreases heart rate, contractility, and BP) and lungs (promotes bronchospasm).

Indication: Used alone or in combination with other antihypertensive agents for management of hypertension; long-term management of angina pectoris; MI (immediate-release tablets and injection); treatment of stable, symptomatic (New York Heart Association [NYHA] class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin ( Toprol XL only).

Unlabeled Uses

Acute coronary syndrome (ST-elevation MI, non–ST-elevation MI, and unstable angina); atrial fibrillation; prevention of migraine.

Nipresol is a cardioselective beta1-blocker without intrinsic sympathomimetic activity. This medication has antihypertensive, antianginal and antiarrhythmic effect. Nipresol decreases automaticity of sinus node, reducing heart rate, slows AV-conduction, decreases myocardial contractility and excitability, reduces cardiac output, reduces myocardial oxygen demand. This drug inhibits the stimulatory effect of catecholamines on the heart during physical and psycho-emotional stress.

Nipresol causes a hypotensive effect which is stabilized by the end of the second week of a course. With angina Nipresol reduces the frequency and severity of attacks.

This medicine also normalizes the heart rate during supraventricular tachycardia and atrial fibrillation; when myocardial infarction it contributes to limit the zone of ischemia of the heart muscle and reduces the risk of developing fatal arrhythmias, reduces the risk of recurrence of myocardial infarction. When Nipresol is used in the medium therapeutic doses it has a less pronounced effect on smooth muscles of the bronchi and peripheral arteries than non-selective beta-blockers.

Nipresol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).

Indications:

  • Controlling high blood pressure (hypertension)
  • Relieving angina symptoms
  • Improving survival following a heart attack.

  • Nipresol helps to keep your blood pressure under control. It may also be used to treat certain heart diseases such as angina pectoris (chest pain), arrhythmia (irregular heart beats) and heart failure. Nipresol is also used to reduce the risk of heart complications after a heart attack. Nipresol may also be used to relieve palpitations (fast and irregular heartbeats) commonly experienced by people with an overactive thyroid gland.

    Oral Hypertension

    Adult: Conventional preparation: Initially, 50-100 mg daily in single or 2 divided doses; may increase wkly to 400 mg daily depending on response.

    Maintenance: 100-200 mg daily; up to 400 mg daily. Extended-release preparation: 25-100 mg once daily. Hepatic impairment: Reduce dose. Oral Angina pectoris

    Adult: 50-100 mg bid-tid. Hepatic impairment: Reduce dose. Oral Cardiac arrhythmias

    Adult: 50 mg bid-tid; increased to 300 mg daily in divided doses if needed. Hepatic impairment: Reduce dose. Oral Adjunct in hyperthyroidism

    Adult: 50 mg 4 times daily. Hepatic impairment: Reduce dose. Oral Prophylaxis of migraine

    Adult: 100-200 mg daily in divided doses. Hepatic impairment: Reduce dose. Oral Stable symptomatic heart failure

    Adult: As a modified-release preparation of Nipresol succinate: Initially, 12.5-25 mg of equivalent Nipresol tartrate dose. Increase, as tolerated, at 2-wk intervals to a max of 20 mg once daily. Hepatic impairment: Reduce dose. Intravenous Emergency treatment of cardiac arrhythmias

    Adult: Initially, up to 5 mg at a rate of 1-2 mg/min; may repeat at 5-minute intervals if needed up to a total dose of 10-15 mg. When acute arrhythmias are controlled, initiate maintenance therapy 4-6 hr after IV therapy using oral therapy not exceeding 50 mg tid. Hepatic impairment: Reduce dose. Intravenous Prophylaxis or control of arrhythmias on induction of anaesthesia

    Adult: 2-4 mg as slow inj; may repeat injections of 2 mg as necessary up to a max total dose of 10 mg. Hepatic impairment: Reduce dose. Intravenous Adjunct in the early management of acute myocardial infarction

    Adult: Admin within 12 hr of the onset of chest pain, 5 mg at 2-minute intervals to a total of 15 mg, if tolerated. After 15 minutes, for patients who have received full IV dose: Initiate oral therapy of 50 mg every 6 hr for 2 days; for patients who did not tolerate the full IV dose: Reduced oral dose should be given as and when their condition permits. Subsequent

    Maintenance: 100 mg bid via oral route. Hepatic impairment: Reduce dose.

    Indications:

    Adult: PO HTN Initial: 50-100 mg/day in single or divided doses; increase slowly according to response.

    Maintenance: 100-200 mg/day. Extended-release 25-100 mg once daily. Angina pectoris 50-100 mg 2-3 times/day. Cardiac arrhythmias 50 mg 2-3 times/day; up to 300 mg/day in divided doses if needed. Adjunct in hyperthyroidism 50 mg 4 times/day. Migraine prophylaxis 100-200 mg/day in divided doses. Adjunct in the early management of acute MI 100 mg twice daily once clinical condition of patient is stable. Stable symptomatic heart failure As succinate: Extended release Initial: 12.5-25 mg of equiv Nipresol tartrate dose. Increase slowly as needed. Max: 20 mg once daily. IV Emergency treatment of cardiac arrhythmias Initial: ≤5 mg at a rate of 1-2 mg/min; repeat at 5-min intervals if needed up to a total of 10-15 mg. Maintenance via oral therapy: ≤50 mg 3 times/day 4-6 hr after IV regimen. Prevention or control of arrhythmias on induction of anesth 2-4 mg as slow inj; repeat as needed. Max total: 10 mg. Adjunct in the early management of acute MI Administer w/in 12 hr of the onset of chest pain, 5 mg at 2-min intervals to a total of 15 mg, if tolerated. After 15 mins, initiate oral therapy at 50 mg 6 hrly for 2 days for patients who received the full IV dose. Subsequent

    Maintenance: 100 mg PO twice daily.

    Oral hypertension

    Adult: As tartrate: Conventional preparation: Initially, 50-100 mg daily in single or divided doses; may increase wkly to 400 mg daily according to response.

    Maintenance: 100-200 mg daily. Extended-release preparation: 25-100 mg once daily. Hepatic impairment: Reduce dose. Oral Angina pectoris

    Adult: As tartrate: 50-100 mg bid-tid. Hepatic impairment: Reduce dose. Oral cardiac arrhythmias

    Adult: As tartrate: 50 mg bid-tid; increase to 300 mg daily in divided doses if needed. Hepatic impairment: Reduce dose. Oral Adjunct in the treatment of hyperthyroidism

    Adult: As tartrate: 50 mg 4 times daily. Hepatic impairment: Reduce dose. Oral Migraine prophylaxis

    Adult: As tartrate: 100-200 mg daily in divided doses. Hepatic impairment: Reduce dose. Oral Adjunct in the early management of acute myocardial infarction

    Adult: As tartrate: 100 mg bid once clinical condition of patient is stable. Hepatic impairment: Reduce dose. Oral Stable symptomatic heart failure

    Adult: As a modified-release preparation of Nipresol succinate: Initially, 12.5-25 mg of equivalent Nipresol tartrate dose. Increase, as tolerated, at 2-wk intervals to a max of 20 mg once daily. Hepatic impairment: Reduce dose. Intravenous Emergency treatment of cardiac arrhythmias

    Adult: As tartrate: Initially, up to 5 mg at a rate of 1-2 mg/min; repeat at 5-min intervals if needed up to a total of 10-15 mg. When arrhythmia is controlled, initiate maintenance oral doses not exceeding 50 mg tid 4-6 hr after IV regimen. Hepatic impairment: Reduce dose. Intravenous Prevention or control of arrhythmias on induction of anaesthesia

    Adult: As tartrate: 2-4 mg as slow inj; repeat as necessary to a max total dose of 10 mg. Hepatic impairment: Reduce dose. Intravenous Adjunct in the early management of acute myocardial infarction

    Adult: As tartrate: Admin within 12 hr of the onset of chest pain, 5 mg at 2-min intervals to a total of 15 mg, if tolerated. After 15 min, initiate oral therapy of 50 mg every 6 hr for 2 days.

    Maintenance: 100 mg bid by mouth. Hepatic impairment: Reduce dose.

    Active ingredients: Metoprolol
    Unit description, dosagePrice, USD

    List of nipresol brand and generic drugs

    Nexmet XL
    Nexmet XL 12.5 mg Tablet$ 0.03
    Novo-Metoprol (Canada)
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    Novo-Metoprol Uncoated
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    Nu-Metop (Canada)
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    Olmax M
    Olmax M 20+50 Tablet$ 0.20
    Olmesar M
    Olmesar M 50+20 Tablet$ 0.18
    Olmesar M 20+25 Tablet$ 0.16
    Olsar M
    Olsar M 20+50 Capsule$ 0.16
    Olsar M 20+25 Capsule$ 0.14
    Opol
    Opol 50 mg Tablet$ 0.05
    Opol 25 mg Tablet$ 0.04
    Opol 100 mg Tablet$ 0.08
    Pharex Metoprolol (Philippines)
    Pharex Metoprolol 50 mg x 100's$ 7.25
    Pharex Metoprolol 100 mg x 100's$ 12.12
    Pharmaniaga Metoprolol (Malaysia)
    Pharmaniaga Metoprolol 100 mg x 50 x 10's
    PHL-Metoprolol-L
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 25 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 25 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    PMS-Metoprolol (Canada)
    PMS-Metoprolol-B
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    PMS-Metoprolol-L
    Tablet; Oral; Metoprolol Tartrate 100 mg
    Tablet; Oral; Metoprolol Tartrate 25 mg
    Tablet; Oral; Metoprolol Tartrate 50 mg
    Tablets; Oral; Metoprolol Tartrate 100 mg
    Tablets; Oral; Metoprolol Tartrate 25 mg
    Tablets; Oral; Metoprolol Tartrate 50 mg
    Preblok

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