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Nodik

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Nodik uses and description

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Nodik - Used for: Treating certain parasitic infections of the intestine.

Nodik is an antiparasitic agent. It works by interfering with the production of certain substances that are needed by the parasite to live.

Nodik is an antiprotozoal agent.

Nodik is used to treat diarrhea in adults and children caused by the protozoa Giardia lamblia. Nodik is also used to treat diarrhea caused by the protozoa Cryptosporidium parvum. These conditions are also sometimes referred to as travelers' diarrhea.

Nodik may also be used for purposes other than those listed in this medication guide.

Pharmacology: Interferes with pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism.

Indication: Treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.

Nodik is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antineoplastic activity by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that Nodik inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), all folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Nodik is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, Nodik is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, to a lesser extent, in normal tissues. Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.

Oral Giardiasis, Cryptosporidiosis

Adult: 500 mg every 12 hr for 3 days.

Child: 1-3 yr: 100 mg every 12 hr; 4-11 yr: 200 mg every 12 hr; ≥12 yr: 500 mg every 12 hr. All doses to be taken for 3 days.

Indications:

Adult: PO Cryptosporidiosis; Giardiasis 500 mg 12 hrly for 3 days.

Active ingredients: Nitazoxanide
Unit description, dosagePrice, USD

List of nodik brand and generic drugs

Nizonide DT
Nizonide DT 200 mg Tablet$ 0.11
Nor-Tripar (Dominican Republic, El Salvador, Guatemala, Honduras, Nicaragua)
Noxom (Peru)
Noxzolin (Peru)
NOZOA (India)
500 mg x 6's$ 0.77
30ml$ 0.45
Nozoa 500mg TAB / 6$ 0.77
Nozoa - SUSP / 30ml$ 0.45
Nozoa 500 mg Tablet$ 0.13
Nozoa 30 ml Suspension$ 0.08
NTZ
Nytax (Colombia)
Padovantan (Mexico)
Padovanton
Suspension; Oral; Nitazoxanide 100 mg / 5 ml
Tablet; Oral; Nitazoxanide 500 mg
Paramix (Dominican Republic, Guatemala, Mexico, Panama)
Dragee; Oral; Nitazoxanide 500 mg
Suspension; Oral; Nitazoxanide 100 mg / 5 ml
Tablet, Dispersible; Oral; Nitazoxanide 100 mg
Tablet, Dispersible; Oral; Nitazoxanide 200 mg
Tablet, Dispersible; Oral; Nitazoxanide 250 mg
Paraxin (Colombia, Ethiopia, India)
Capsule; Oral; Chloramphenicol; Chloramphenicol Palmitate
Injectable; Injection; Chloramphenicol; Chloramphenicol Palmitate
Drops; Oral; Chloramphenicol; Chloramphenicol Palmitate
Ointment; Topical; Chloramphenicol; Chloramphenicol Palmitate
PARAXIN Capsule/ Tablet / 250mg (10 units)$ 0.85
PARAXIN Capsule/ Tablet / 500mg (6 units)$ 0.97
Paraxin 250mg SC-TAB / 10$ 0.85
Paraxin 250mg CAP / 10$ 0.85
Paraxin 500mg CAP / 6$ 0.97
Paraxin 125mg/5mL SUSP / 100ml$ 1.20
Paraxin 1g INJ / 1$ 0.48
250 mg x 10's$ 0.85
500 mg x 6's$ 0.97
125 mg x 5 mL x 100ml$ 1.20
1 g x 1's$ 0.48
Pardil (Peru)
Parsenida
Tablet; Oral; Nitazoxanide 200 mg
Tablet; Oral; Nitazoxanide 500 mg
Phavic-1
Plantassel (El Salvador, Guatemala, Honduras, Nicaragua, Panama)
Proxanida (Colombia)
Repinox (Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Nicaragua, Panama)

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