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Nor-Tripar

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Nor-Tripar uses and description

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Nor-Tripar - Used for: Treating certain parasitic infections of the intestine.

Nor-Tripar is an antiparasitic agent. It works by interfering with the production of certain substances that are needed by the parasite to live.

Nor-Tripar is an antiprotozoal agent.

Nor-Tripar is used to treat diarrhea in adults and children caused by the protozoa Giardia lamblia. Nor-Tripar is also used to treat diarrhea caused by the protozoa Cryptosporidium parvum. These conditions are also sometimes referred to as travelers' diarrhea.

Nor-Tripar may also be used for purposes other than those listed in this medication guide.

Pharmacology: Interferes with pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism.

Indication: Treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.

Nor-Tripar is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antineoplastic activity by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that Nor-Tripar inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), all folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Nor-Tripar is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, Nor-Tripar is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, to a lesser extent, in normal tissues. Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.

Oral Giardiasis, Cryptosporidiosis

Adult: 500 mg every 12 hr for 3 days.

Child: 1-3 yr: 100 mg every 12 hr; 4-11 yr: 200 mg every 12 hr; ≥12 yr: 500 mg every 12 hr. All doses to be taken for 3 days.

Indications:

Adult: PO Cryptosporidiosis; Giardiasis 500 mg 12 hrly for 3 days.

Active ingredients: Nitazoxanide
Unit description, dosagePrice, USD

List of nor-tripar brand and generic drugs

Nodik (Colombia, El Salvador, Guatemala, Honduras, Panama)
Noxom (Peru)
Noxzolin (Peru)
NOZOA (India)
500 mg x 6's$ 0.77
30ml$ 0.45
Nozoa 500mg TAB / 6$ 0.77
Nozoa - SUSP / 30ml$ 0.45
Nozoa 500 mg Tablet$ 0.13
Nozoa 30 ml Suspension$ 0.08
NTZ
Nytax (Colombia)
Padovantan (Mexico)
Padovanton
Suspension; Oral; Nitazoxanide 100 mg / 5 ml
Tablet; Oral; Nitazoxanide 500 mg
Paramix (Dominican Republic, Guatemala, Mexico, Panama)
Dragee; Oral; Nitazoxanide 500 mg
Suspension; Oral; Nitazoxanide 100 mg / 5 ml
Tablet, Dispersible; Oral; Nitazoxanide 100 mg
Tablet, Dispersible; Oral; Nitazoxanide 200 mg
Tablet, Dispersible; Oral; Nitazoxanide 250 mg
Paraxin (Colombia, Ethiopia, India)
Capsule; Oral; Chloramphenicol; Chloramphenicol Palmitate
Injectable; Injection; Chloramphenicol; Chloramphenicol Palmitate
Drops; Oral; Chloramphenicol; Chloramphenicol Palmitate
Ointment; Topical; Chloramphenicol; Chloramphenicol Palmitate
PARAXIN Capsule/ Tablet / 250mg (10 units)$ 0.85
PARAXIN Capsule/ Tablet / 500mg (6 units)$ 0.97
Paraxin 250mg SC-TAB / 10$ 0.85
Paraxin 250mg CAP / 10$ 0.85
Paraxin 500mg CAP / 6$ 0.97
Paraxin 125mg/5mL SUSP / 100ml$ 1.20
Paraxin 1g INJ / 1$ 0.48
250 mg x 10's$ 0.85
500 mg x 6's$ 0.97
125 mg x 5 mL x 100ml$ 1.20
1 g x 1's$ 0.48
Pardil (Peru)
Parsenida
Tablet; Oral; Nitazoxanide 200 mg
Tablet; Oral; Nitazoxanide 500 mg
Phavic-1
Plantassel (El Salvador, Guatemala, Honduras, Nicaragua, Panama)
Proxanida (Colombia)
Repinox (Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Nicaragua, Panama)
Tazox (Bangladesh)
Tazox 1g VIAL / 1$ 0.81

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