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Orapred

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Orapred uses and description

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Orapred - Orapred is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Orapred restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Orapred contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Orapred inhibits the activity of fibroblasts and collagen formation.

Orapred inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.

Orapred reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.

Orapred inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.

Orapred has a vasoconstrictor effect with direct application to the vessels.

Orapred has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Orapred enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.

Orapred inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.

Orapred also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Orapred affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.

In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.

When systemic use the therapeutic activity of Orapred is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local application the therapeutic activity of Orapred is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

As compared with hydrocortisone the anti-inflammatory activity of Orapred is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.

Orapred is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Orapred is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

Indication: For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Indications: corticosteroid

OralAllergic conditions; collagen diseases (eg, systemic lupus erythematous, acute rheumatic carditis); dermatologic diseases; edematous states; endocrine conditions; GI diseases; hematologic diseases; neoplastic conditions; neoplastic diseases; nervous system conditions (eg, acute exacerbations of multiple sclerosis); ophthalmic conditions; conditions related to organ transplantation; pulmonary disease (eg, asthma); renal condition (eg, nephrotic syndrome); rheumatologic conditions; specific infectious diseases including trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concomitantly with appropriate antituberculous chemotherapy; tuberculosis with pleural or pericardial effusion. Ophthalmic Econopred Plus, Prednisol, Pred ForteTreatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Econopred Plus, PrednisolTreatment of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Pred MildTreatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).

Indications: Replacement therapy: Adrenal insufficiency.

Adrenogenital syndrome.

Nonendocrine diseases: Rheumatoid arthirits.

Osteoarthritis, Acute gouty arthirits.

Collagen diseases e.

g.

systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases.

Severe allergic reactions e.

g.

anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases.

Autoimmune diseases e.

g.

haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases.

Other lung diseases e.

g.

pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth.

Infective diseases e.

g.

severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic c

Active ingredients: Prednisolone
Unit description, dosagePrice, USD
Solution; Oral; Prednisolone Sodium Phosphate 15 mg / 5 ml
Orapred 5 mg Tablet$ 0.01

List of orapred brand and generic drugs

Opredsone (Thailand)
Opredsone 5 mg x 1,000's
Orapred Forte
Orapred Forte 10 mg Tablet$ 0.02
Orapred ODT (United States)
Tablet, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 10 mg
Tablet, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 15 mg
Tablet, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 30 mg
Tablets, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 10 mg
Tablets, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 15 mg
Tablets, Orally Disintegrating; Oral; Prednisolone Sodium Phosphate 30 mg
Orapred Plus
Orapred Plus 20 mg Tablet$ 0.04
Ortilone
Ortilone 5 mg Tablet$ 0.01
Panafcortelone (Australia)
Tablet; Oral; Prednisolone 1 mg
Tablet; Oral; Prednisolone 25 mg
Tablet; Oral; Prednisolone 5 mg
Panafcortelone 1 mg x 1,000's$ 110.00
Panafcortelone 5 mg x 60's$ 23.00
Panafcortelone 25 mg x 30's$ 42.00
Tablets; Oral; Prednisolone 1 mg
Tablets; Oral; Prednisolone 25 mg
Tablets; Oral; Prednisolone 5 mg
Paracortol
Paracotol
Pediacort (Venezuela)
Pediapred (Canada, United States)
Solution; Oral; Prednisolone Sodium Phosphate 5 mg / 5 ml
Pedipred (Bangladesh)
Pednisol (Bangladesh)
PEDNISOL Capsule/ Tablet / 5mg (10 units)$ 0.07
PEDNISOL Capsule/ Tablet / 40mg (10 units)$ 0.47
PEDNISOL Capsule/ Tablet / 20mg (10 units)$ 0.24
PEDNISOL Capsule/ Tablet / 10mg (10 units)$ 0.13
Pelonine (Taiwan)
Pelonine 5 mg
Pelonine 5 mg x 1000's
Pensone (India)
Pensone 5mg TAB / 10$ 0.08
Pensone 10mg TAB / 10$ 0.14
Pensone 20mg TAB / 10$ 0.25
Pensone 40mg TAB / 10$ 0.49
5 mg x 10's$ 0.08
10 mg x 10's$ 0.14
20 mg x 10's$ 0.25
40 mg x 10's$ 0.49
Pharmacort 20
Pharmacort 5
Pidonin (Taiwan)
Pidonin 5 mg
PMS-Prednisolone
Solution; Oral; Prednisolone Sodium Phosphate 5 mg / 5 ml

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