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Orfiril retard

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Orfiril retard uses and description

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Orfiril retard - Used for: Treating certain seizure disorders. It may also be used for other conditions as determined by your doctor.

Orfiril retard is an anticonvulsant. It works by increasing the amount of a certain chemical in the brain.

Orfiril retard affects chemicals in the body that may be involved in causing seizures.

Orfiril retard is used to treat various types of seizure disorders. Orfiril retard is sometimes used together with other seizure medications.

Orfiril retard may also be used for purposes not listed in this medication guide.

Orfiril retard is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, Orfiril retard is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. Orfiril retard is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Orfiril retard dissociates to the valproate ion in the gastrointestinal tract. Orfiril retard has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with Orfiril retard in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection.

Oral Prophylaxis of migraine

Adult: As valproate semisodium: Initially, 250 mg bid. Max: 1 g daily.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid. Oral Acute manic episodes of bipolar disorder

Adult: As valproate semisodium: Initially, 750 mg daily in divided doses, increase as fast as possible to achieve optimal response or desired range of trough plasma concentrations between 50-125 mcg/ml. Max: 60 mg/kg daily.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid. Oral Complex partial seizures

Adult: As monotherapy, conversion to monotherapy or adjunctive therapy: Given as Orfiril retard or valproate semisodium, initially 10-15 mg/kg/day in 2-4 divided doses, increased by 5-10 mg/kg/wk. Max: 30mg/kg/day. Given as sodium valproate, 600 mg daily in 2 divided doses, increased by 200 mg every 3 days. Usual range: 1-2 g daily (20 - 30 mg/kg daily). Max: 2.5 g daily.

Child: As monotherapy, conversion to monotherapy or adjunctive therapy: Given as sodium valproate: >20kg: 400 mg/day in 2 divided doses, increased gradually until control achieved. Usual range: 20-30 mg/kg/day. Max: 35mg/kg/day. <20kg: 20mg/kg daily in 2 divided doses, increased to 40mg/kg daily in severe cases, with serum Orfiril retard monitoring. Monitor clinical chemistry and haematological parameters if doses >40mg/kg daily used. Given as Orfiril retard or valproate semisodium for ≥10 yr: initially, 10-15 mg/kg/day in 2-4 divided doses, increased by 5-10 mg/kg/wk. Max: 30mg/kg/day.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid. Oral Simple and complex absence seizures

Adult: As monotherapy, conversion to monotherapy or adjunctive therapy: Given as Orfiril retard or valproate semisodium, initially 15 mg/kg/day in 2-4 divided doses, increased by 5-10 mg/kg/wk. Max: 30 mg/kg/day.

Child: As monotherapy, conversion to monotherapy or adjunctive therapy: Given as sodium valproate: >20kg: 400 mg/day in 2 divided doses, increased gradually until control achieved. Usual range: 20-30 mg/kg/day. Max: 35mg/kg/day. <20kg: 20mg/kg daily in 2 divided doses, increased to 40mg/kg daily with serum Orfiril retard monitoring in severe cases. Monitor clinical chemistry and haematological parameters if > 40mg/kg daily. Given as Orfiril retard or valproate semisodium ≥10 yr: Initially 15 mg/kg/day in 2-4 divided doses, increased by 5-10 mg/kg/wk. Max: 30mg/kg/day.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid. Oral Bipolar disorder

Adult: As valpromide: 900-1800 mg daily in 2 divided doses. Usual dose: 1200 mg daily. Initiate at required dose or dosage may be increased every 2-3 days to reach optimal dose in 2 wk with simultaneous and progressive dose reduction of concurrent psychotropic drugs. Intravenous Complex partial seizures

Adult: Given as sodium valproate: Initially 400-800 mg daily increasing by 150-300 mg every 3 days until control is achieved. Usual dose: 20-30 mg/kg/day. Daily doses to be given in 3-4 divided doses. Each dose to be given as slow IV Inj over 3-5 minutes or by infusion in 0.9% saline or 5% dextrose over 60 minutes (Max rate: 20 mg/minute). Max: 2.5 g daily.

Child: Given as sodium valproate: Initially 300mg/day increased until control is achieved. Usual range: 20-30 mg/kg/day. Max: 40 mg/kg/day with plasma Orfiril retard levels monitoring.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid. Intravenous Simple and complex absence seizures

Adult: Given as sodium valproate: Initially 400-800 mg daily increasing by 150-300 mg every 3 days until control is achieved. Usual dose: 20-30 mg/kg/day. Daily doses to be given in 3-4 divided doses. Each dose to be given as slow IV Inj over 3-5 minutes or by infusion in 0.9% saline or 5% dextrose over 60 minutes (Max rate: 20 mg/minute). Max: 2.5 g daily.

Child: Given as sodium valproate: Initially 300mg/day increased until control is achieved. Usual range: 20-30 mg/kg/day. Max: 40 mg/kg/day with plasma Orfiril retard levels monitoring.

Elderly: Initiate at lower dose and increase slowly. Renal impairment: Dose adjustments may be needed. Hepatic impairment: Avoid.

Indications:

Adult: PO Migraine prophylaxis As valproate semisodium: Initial: 250 mg twice daily. Max: 1 g/day. Acute manic episodes of bipolar disorder As valproate semisodium: Initial: 750 mg/day in divided doses, increase as needed based on response. Max: 60 mg/kg/day. Complex partial seizures As Orfiril retard or valproate semisodium: Initial: 10-15 mg/kg/day in 2-4 divided doses, increase if needed. Max: 30 mg/kg/day. As Na valproate: 600 mg/day in 2 divided doses, increase if needed. Usual: 1-2 g/day. Max: 2.5 g/day. Simple and complex absence seizures As Orfiril retard or valproate semisodium: As monotherapy, conversion to monotherapy or adjunctive therapy: Initial: 15 mg/kg/day in 2-4 divided doses, increase if needed. Max: 30 mg/kg/day. Bipolar disorder As valpromide: 0.9-1.8 g/day in 2 divided doses. Usual: 1.2 g/day. May increase slowly to reach optimal dose w/ simultaneous and progressive dose reduction of concurrent psychotropic drugs. IV Complex partial seizures; Simple and complex absence seizures As Na valproate: Initial: 400-800 mg/day, increase slowly until control is achieved. Usual: 20-30 mg/kg/day. Daily doses to be given in 3-4 divided doses. Max: 2.5 g/day.

Orfiril retard is used to treat epilepsy (also known as fits or seizures). It may be used on its own or together with other epilepsy medicines. Orfiril retard may also be used to treat other conditions as decided by your doctor.

Orfiril retard Syrup (Valproic Acid Oral Solution, USP) is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. Orfiril retard Syrup (Valproic Acid Oral Solution, USP) is indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types which include absence seizures. Simple absence is defined as very brief clouding of the sensorium or loss of consciousness accompanied by certain generalized epileptic discharges without other detectable clinical signs. Complex absence is the term used when other signs are also present. SEE WARNINGS

Active ingredients: Valproic Acid
Unit description, dosagePrice, USD

List of orfiril retard brand and generic drugs

Orlept (Georgia, United Kingdom)
Tablet, Enteric Coated; Oral; Valproic Acid (Valproate Sodium) 200 mg
Tablet, Enteric Coated; Oral; Valproic Acid (Valproate Sodium) 500 mg
Orlept SF
Solution; Oral; Valproic Acid (Valproate Sodium) 200 mg / 5 ml
Penta-Valproic
Petilin (Cyprus, Kenya, Romania)
PHL-Divalproex
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 125 mg
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 250 mg
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 500 mg
PHL-Valproic Acid EC
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Pimiken
PMS-Divalproex (Canada)
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 125 mg
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 250 mg
Tablet, Enteric Coated; Oral; Valproic Acid (Divalproex Sodium) 500 mg
PMS-Valproic Acid (Canada)
PMS-Valproic Acid EC
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Prodepa (Latvia, Lithuania)
Propymal (Netherlands)
Proteval
Proval (Bangladesh)
Provetal
ratio-Valproic (Canada)
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Capsule; Oral; Valproic Acid 250 mg
Ratio-Valproic EC
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Rhoxal-Valproic
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Capsule; Oral; Valproic Acid 250 mg
Sandoz Valproic (Canada)
Capsule, Enteric Coated; Oral; Valproic Acid 500 mg
Sanoten (Japan)
Selenica
Selenica R (Japan)
sodio valproato Winthrop (Italy)
Sodium Valproat Sannova (Japan)
Sodium Valproate Sandoz (Australia)
Sodium Valproate SR (Japan)
Sodium Valproate Zentiva (United Kingdom)
Soval (Bangladesh)
Soval 200 mg x 10 Blister x 10 Tablet
Sprinkle
Stavzor (United States)
Capsule, Delayed Release; Oral; Valproic Acid 125 mg
Capsule, Delayed Release; Oral; Valproic Acid 250 mg
Capsule, Delayed Release; Oral; Valproic Acid 500 mg
Tekaval
Torval CR (Brazil)

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