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Oxaliplatino

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Oxaliplatino uses and description

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Oxaliplatino - Oxaliplatino is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Oxaliplatino is used together with other cancer medications to treat colon and rectal cancer.

Oxaliplatino may also be used for other purposes not listed in this medication guide.

Used for: Treating advanced cancer of the colon or rectum in certain patients. It is usually used in combination with other medicines.

Oxaliplatino is an antineoplastic. It works by killing cancer cells and slowing tumor growth.

Pharmacology: The cytotoxic effect of Oxaliplatino has been correlated with formation of inter- and intrastrand DNA crosslinks that inhibit DNA replication and transcription. Cytotoxicity is cell-cycle nonspecific.

Indication: Adjuvant treatment of stage III colon cancer in combination with infusional 5-fluorouracil/leucovorin in patients who have undergone complete resection of the primary tumor; in combination with infusional 5-fluorouracil/leucovorin for the treatment of advanced colorectal cancer.

Unlabeled Uses

Treatment of relapsed or refractory non-Hodgkin lymphoma; treatment of advanced ovarian cancer.

Oxaliplatino selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Oxaliplatin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Intravenous Metastatic colorectal cancer

Adult: In combination with fluorouracil and folinic acid: 85 mg/m 2 by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk. After recovery from toxicity, reduce dose to 65 mg/m 2. Administer before fluoropyrimidines. Intravenous Stage III colon cancer

Adult: As adjuvant therapy: 85 mg/m 2 by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk; given for 12 cycles. After recovery from toxicity, reduce dose to 75 mg/m 2. Administer before fluoropyrimidines. Reconstitution: Reconstitute with 10 ml (for 50 mg vial) or 20 ml (for 100 mg vial) water for inj or 5% dextrose inj. Reconstituted solution must be further diluted with 250-500 ml of 5% dextrose inj before admin. Incompatibility: Admixture incompatibility: Alkaline medications or media.

Intravenous Advanced colorectal cancer

Adult: In combination with fluorouracil/leucovorin: 85 mg/m 2 every 2 wk until disease progression or unacceptable toxicity. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%,. After recovery from toxicity, reduce dose to 65 mg/m 2. Administer before fluoropyrimidines. Renal impairment: Dose adjustment may be needed. Intravenous Adjuvant therapy in stage III colon cancer

Adult: In combination with fluorouracil/leucovorin: 85 mg/m 2 every 2 wk for 12 cycles. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk; given for 12 cycles. After recovery from toxicity, reduce dose to 75 mg/m 2. Administer before fluoropyrimidines. Renal impairment: Dose adjustment may be needed. Reconstitution: Reconstitute with 10 ml (for 50 mg vial) or 20 ml (for 100 mg vial) water for inj or 5% dextrose inj. Reconstituted solution must be further diluted with 250-500 ml of 5% dextrose inj before admin. Incompatibility: Admixture incompatibility: Alkaline medications or media.

Indications:

Adult: IV Advanced colorectal cancer W/ fluorouracil and folinic acid: 85 mg/m 2 2 wkly. After recovery from toxicity, reduce to 65 mg/m 2. Administer before fluoropyrimidines. IV Adjuvant therapy in Stage III colon cancer 85 mg/m 2 2 wkly, given for 12 cycles. After recovery from toxicity, reduce to 75 mg/m 2. Administer before fluoropyrimidines.

•adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.•treatment of advanced colorectal cancer.

Active ingredients: Oxaliplatin
Unit description, dosagePrice, USD
Injectable; Injection; Oxaliplatin 100 mg
Injectable; Injection; Oxaliplatin 50 mg

List of oxaliplatino brand and generic drugs

Oxaliplatine-Mylan (Taiwan)
Oxaliplatine-Mylan 5 mg/1 mL x 100 mg
Oxaliplatino Accord (Italy)
Oxaliplatino Actavis (Spain)
Oxaliplatino Biocrom (Argentina)
Oxaliplatino Crinos (Italy)
Oxaliplatino Delta (Argentina)
Oxaliplatino Depronal (Spain)
Oxaliplatino Ebewe (Italy)
Oxaliplatino Hospira (Italy)
Oxaliplatino Kabi (Italy)
Oxaliplatino Kampar (Chile)
Oxaliplatino Mayne (Norway, Spain)
Oxaliplatino Medac (Spain)
Oxaliplatino Milo (Spain)
Oxaliplatino Mylan (Italy, Spain)
Oxaliplatino Ratiopharm (Italy, Spain)
Oxaliplatino Rontag (Argentina)
Oxaliplatino Sandoz (Colombia)
Oxaliplatino Servycal (Argentina)
Oxaliplatino Servycal 50 mg x 1 loï
Oxaliplatino Servycal 100 mg x 1 loï
Oxaliplatino SPI (Spain)
Oxaliplatino Teva (Italy, Spain)
Oxaliplatino Varifarma (Argentina)
Oxaliplatino Winthrop (Italy)
Oxaliplatinum Medac (Czech Republic)
Oxaliplatinum Winthrop (Poland)
Oxaliprol (Greece)
Oxalisin (Netherlands)
Oxalispera
Oxalispera 2mg/mL INJ / 25ml$ 37.04
Oxalispera 2mg/mL INJ / 50ml$ 74.07
Oxalispera 50 mg Injection$ 0.04
Oxalispera 100 mg Injection$ 0.07
Oxaliwin (South Africa)
OXALIZEN (India)
2 mg x 1 mL x 25ml
2 mg x 1 mL x 50ml
Oxalizen 2mg x 1mL VIAL / 25ml
Oxalizen 2mg x 1mL VIAL / 50ml
Oxallon (Vietnam)
Oxallon 50 mg x 1 loï
Oxalpin (Turkey)
Oxaltie (Argentina, Ecuador)
Oxaltie 50 mg x 1 loï
Oxaltie 100 mg x 1 loï
Oxaltina (Greece)

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