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Pentoxol

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Pentoxol uses and description

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Pentoxol - Pentoxol is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Pentoxol is used to treat breast cancer, lung cancer, and ovarian cancer. It is also used to treat AIDS-related Kaposi's sarcoma.

Pentoxol may also be used for other purposes not listed in this medication guide.

Pharmacology: Pentoxol is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, Pentoxol induces abnormal arrays or bundles of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis, further disrupting cell function.

Indication: For the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 mo of adjuvant chemotherapy (prior therapy should have included an anthracycline unless clinically contraindicated); treatment of advanced carcinoma of the ovary ( Onxol only).

Unlabeled Uses

Squamous cell head and neck cancer, small-cell lung cancer, bladder cancer, esophageal cancer, testicular cancer, endometrial cancer, prostate cancer, gastric cancer, germ cell tumors, refractory leukemia, and recurrent Wilms tumor in children.

Pentoxol is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. Pentoxol is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, Pentoxol induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Intravenous Ovarian carcinoma

Adult: Primary treatment (in combination with cisplatin or carboplatin): 135 mg/m 2 infused over 24 hr followed by cisplatin and repeated at 3 wk intervals. Secondary treatment (as single agent): 135 or 175 mg/m 2 infused over 3 hr once every 3 wk. Hepatic impairment: Do not use in severe impairment, increased risk of hepatotoxicity. For detailed dosing recommendations, consult local protocol. Intravenous Breast cancer

Adult: Adjuvant therapy; 2nd line monotherapy or 1st line treatment with trastuzumab: 175 mg/m 2 infused over 3 hr once every 3 wk for 4 courses; when used with trastuzumab, dose should be given the day after the 1st dose of trastuzumab or immediately after subsequent doses if well-tolerated. 1st line with doxorubicin: 220 mg/m 2 over 3 hr every 3 wk, dose to be administered 24 hr after doxorubicin. Hepatic impairment: Do not use in severe impairment, increased risk of hepatotoxicity. For detailed dosing recommendation, consult local protocol. Intravenous Advanced non-small cell lung cancer

Adult: 135 mg/m 2 over 24 hr or 175 mg/m 2 over 3 hr, followed by cisplatin and repeated at 3 wk intervals. Hepatic impairment: Do not use in severe impairment, increased risk of hepatotoxicity. For detailed dosing recommendation, consult local protocol. Intravenous AIDS-related Kaposi's sarcoma

Adult: 135 mg/m 2 over 3 hr every 3 wk. Alternatively, 100 mg/m 2 over 3 hr every 2 wk especially in patients with poor performance status. Hepatic impairment: Do not use in severe impairment, increased risk of hepatotoxicity. For detailed dosing recommendation, consult local protocol. Reconstitution: Pentoxol must be diluted before infusion. It can be diluted in 0.9% sodium chloride inj, 5% dextrose inj, 5% dextrose and 0.9% sodium chloride inj or 5% dextrose in lactated Ringer's inj to a concentration of 0.3-1.2 mg/ml. Incompatibility: Do not prepare, store or administer in PVC containing equipment; macrogol glycerol ricinolate (an excipient) can cause [di-(2-ethylhexyl)phthalate] (DEHP) leaching. Y-site incompatibility: Amphotericin B, amphotericin B cholesteryl sulfate complex, chlorpromazine, doxorubicin liposome, hydroxyzine, methylprednisolone sodium succinate, mitoxantrone. Variable compatibility when admixed with cisplatin.

Indications:

Adult: IV Ovarian carcinoma Primary treatment: 135 mg/m 2, followed by cisplatin. Repeat 3 wkly. Secondary treatment: As single agent: 135 or 175 mg/m 2 3 wkly. Breast cancer As adjunct therapy, 2nd line monotherapy or 1st line treatment w/ trastuzumab: 175 mg/m 2 3 wkly for 4 courses. W/ trastuzumub, give dose one day after 1st dose of trastuzumab or immediately after subsequent doses if tolerated. 1st line treatment w/ doxorubicin: 220 mg/m 2 3 wkly, give dose 24 hr after doxurubicin. Advanced non-small cell lung cancer 135 mg/m 2 over 24 hr, followed by cisplatin. Repeat 3 wkly. AIDS-related Kaposi's sarcoma 135 mg/m 2 3 wkly.

Active ingredients: Paclitaxel
Unit description, dosagePrice, USD
Injectable; Injection; Paclitaxel 6 mg / ml

List of pentoxol brand and generic drugs

PCH-Paclitaxel (South Africa)
Petaxel (India)
PETAXEL Injection / 6mg (5ml units)$ 33.00
PETAXEL Injection / 6mg (16.7ml units)$ 74.00
PETAXEL Injection / 6mg (43.4ml units)$ 158.33
6 mg x 1 mL x 16.7ml$ 74.00
6 mg x 1 mL x 5ml$ 33.00
Petaxel 6mg x 1mL INJ / 16.7ml$ 74.00
Petaxel 6mg x 1mL INJ / 5ml$ 33.00
Phytoqule
Phytoqule 30mg INJ / 1$ 36.67
Phytoqule 100mg INJ / 1$ 92.22
Phytoqule 260mg INJ / 1$ 166.30
Phyxol (Taiwan)
Phyxol 6 mg/1 mL x 5 mL
Phyxol 6 mg/1 mL x 10 mL
Phyxol 6 mg/1 mL x 15 mL
Phyxol 6 mg/1 mL x 16.7 mL
Phyxol 6 mg/1 mL x 17 mL
Phyxol 6 mg/1 mL x 25 mL
Phyxol 6 mg/1 mL x 50 mL
Placlitax (Colombia)
Plaxel (Vietnam)
Plaxel 30 30 mg/5 mL x 1 loï x 5 mL
Plaxel 100 mg/16.67 mL x 1 loï x 16.67 mL
Plaxicel
Poltaxel (Poland)
Praxel (Chile, Mexico, Peru)
Injectable; Injection; Paclitaxel 6 mg / ml
Praxel 30 mg/5 mL x 1's
Praxel 100 mg/16.67 mL x 1's
Praxel 300 mg/50 mL x 1's
Praxene (Slovenia)
Ribotax (Germany)
Sandoz Paclitaxel (Philippines)
Sandoz Paclitaxel (vial) 6 mg/1 mL x 5 mL
Sandoz Paclitaxel 6 mg/1 mL x 16.6 mL
Sindaxel (Georgia, Poland, Romania, Slovakia)
Injectable; Injection; Paclitaxel 6 mg / ml
Sindaxel 30 mg/5 mL x 1's$ 91.80
Sindaxel 100 mg/16.67 mL x 1's$ 255.00
Sindaxel 260 mg/43.33 mL x 1's$ 571.20
Sindaxel 100 mg/16.7 mL x 1's
Sindaxel 150 mg/25 mL x 1's
Sindaxel 260 mg/43.3 mL x 1's
Sindaxel 300 mg/50 mL x 1's
Taclipaxol
Taclix
Taksen

Show all Pentoxol generic names
 
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