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Peryl

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Peryl uses and description

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Peryl - Peryl is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.

Peryl is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease.

Peryl may also be used for purposes not listed in this medication guide.

Peryl is a nonsulfhydryl prodrug that is metabolized via first pass effect (62%) and systemic hydrolysis (38%) to perindoprilat, its active metabolite, following oral administration. Perindoprilat lowers blood pressure by antagonizing the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may sustain the effects of perindoprilat by causing increased vasodilation and decreased blood pressure.

Peryl helps to keep your blood pressure under control. Peryl relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Peryl may also be used to treat other conditions, for example, heart failure.

Oral Hypertension

Adult: As erbumine: Initially, 4 mg once daily. 1st dose preferably given at bedtime. Patients with renovascular hypertension, volume depletion, severe hypertension: Initially, 2 mg once daily. Max: 8 mg daily. Patients on diuretics: Withdraw diuretics 2 or 3 days before perindropil therapy. Resume later if required. If diuretic cannot be discontinued, an initial dose of 2 mg once daily may be given.

Elderly: As erbumine: Initially, 2 mg once daily. May be progressively increased to 4 mg after 1 mth then to 8 mg if needed according to renal function. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days. Oral Heart failure

Adult: As erbumine: Initially, 2 mg in the morning. Increase by 2-mg increments at no <2 wk intervals to a maintenance dose of 4 mg/day. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days. Oral Stable ischaemic heart disease

Adult: As erbumine: Initially, 4 mg once daily for 2 wk then titrate up to a maintenance dose of 8 or 10 mg once daily if tolerated.

Elderly: As erbumine: Initially, 2 mg once daily on the 1st wk, increase as tolerated to 4 mg once daily on the 2nd wk, then increase again as tolerated to a maintenance dose of 8 mg once daily. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days.

Oral Hypertension

Adult: As erbumine: Initially, 4 mg once daily. 1st dose preferably given at bedtime. Patients with renovascular hypertension, volume depletion, severe hypertension: Initially, 2 mg once daily. Max: 8 mg daily. Patients on diuretics: Withdraw diuretics 2 or 3 days before perindropil therapy. Resume later if required. If diuretic cannot be discontinued, an initial dose of 2 mg once daily may be given.

Elderly: As erbumine: Initially, 2 mg once daily. May be progressively increased to 4 mg after 1 mth then to 8 mg if needed according to renal function. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days. Oral Heart failure

Adult: As erbumine: Initially, 2 mg in the morning. Increase by 2-mg increments at no <2 wk intervals to a maintenance dose of 4 mg/day. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days. Oral Stable ischaemic heart disease

Adult: As erbumine: Initially, 4 mg once daily for 2 wk then titrate up to a maintenance dose of 8 or 10 mg once daily if tolerated.

Elderly: As erbumine: Initially, 2 mg once daily on the 1st wk, increase as tolerated to 4 mg once daily on the 2nd wk, then increase again as tolerated to a maintenance dose of 8 mg once daily. CrCl (ml/min) Dosage Recommendation 30-60 2 mg daily. 15-30 2 mg on alternate days. <15 2 mg on dialysis days. Special Populations: Renal impairment: CrCl >60 mL/min: 4 mg/day; 30-60 mL/min: 2 mg/day; 15-29 mL/min: 2 mg every other day; <15 mL/min: 2 mg on the day of dialysis. Maintenance dose: 2 mg daily or on alternate days, depending on the ° of impairment. Hepatic impairment: No dosage adjustment needed. Patients receiving diruetics: Discontinue diuretics 2 or 3 days before starting perindopril, resumed later if necessary.

Indications:

Adult: PO HTN As erbumine: Initial: 4 mg once daily. Patients w/ renovascular HTN, vol depletion, severe HTN: Initial: 2 mg once daily. Max: 8 mg/day. Patients on diuretics: Withdraw diuretics 2 or 3 days before perindropil therapy. Resume later if required. If diuretic cannot be discontinued, an initial dose of 2 mg once daily. Max: 8 mg/day. Heart failure As erbumine: Initial: 2 mg in the morning. Increase slowly if needed.

Maintenance: 4 mg/day. Stable ischaemic heart As erbumine: Initial: 4 mg once daily for 2 wk.

Maintenance: 8 or 10 mg once daily.

this medeicine is used:• to treat high blood pressure (hypertension);• to treat heart failure (a condition where the heart is unable to pumpenough blood to meet the body’s needs);• to reduce the risk of cardiac events, such as heart attack, in patientswith stable coronary artery disease (a condition where the bloodsupply to the heart is reduced or blocked) and who have alreadyhad a heart attack and/or an operation to improve the blood supplyto the heart by widening the vessels that supply it. Perindopril Tablets belong to a class of medicines called ACEinhibitors. These work by widening the blood vessels, which makes iteasier for your heart to pump blood through them.

Active ingredients: Perindopril
Unit description, dosagePrice, USD

List of peryl brand and generic drugs

Perineva (Croatia (Hrvatska), Slovenia)
Perinpress
Tablet; Oral; Perindopril Erbumine 2 mg
Tablet; Oral; Perindopril Erbumine 4 mg
Perinsyl (Japan)
Peripil (Taiwan)
Peripil 4 mg
Permetor (Netherlands)
Perotens (Poland)
Pharmacor Perindopril (Australia)
Pinbarix (Czech Republic)
Prenessa (Croatia (Hrvatska), Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, Slovenia)
Tablet; Oral; Perindopril Erbumine 8 mg
Prestarium (Bulgaria, Czech Republic, Estonia, Georgia, Latvia, Lithuania, Poland, Romania, Russian Federation, Slovakia)
Tablet; Oral; Perindopril Erbumine 2 mg
Tablet; Oral; Perindopril Erbumine 4 mg
Tablet; Oral; Perindopril Erbumine 8 mg
Prestarium 10mg - 30 Tablets$ 45.00
Prestarium 5mg - 30 Tablets$ 25.00
Prestarium A
Tablet, Film-Coated; Oral; Perindopril Arginine 10 mg
Tablet, Film-Coated; Oral; Perindopril Arginine 2.5 mg
Tablet, Film-Coated; Oral; Perindopril Arginine 5 mg
Prestarium Arginine (Estonia)
Prestoril
Tablet; Oral; Perindopril Erbumine 2 mg
Tablet; Oral; Perindopril Erbumine 4 mg
Prexanil (Croatia (Hrvatska), Czech Republic, Estonia, Serbia, Slovenia)
Prexanil A (Croatia (Hrvatska))
Prexum (Indonesia, South Africa)
Prill-L
Prill-L Perindopril erbumine 4 mg,losartan potassium 50 mg. TAB / 10
Prindace (Ireland)
Procaptan (Italy)
Provinace (Vietnam)
Provinace 4 mg x 3 Blister x 10 Tablet
Provinace 4 mg x 30's
Ran-Perindopril (South Africa)
Revosyl 8
Serperil (Turkey)
Spopress (Poland)
Stopress (Bulgaria)
Terc-butilaminijev (Slovenia)
Terry White Chemists Perindopril (Australia)
Tablet; Oral; Perindopril Erbumine 2 mg
Tablet; Oral; Perindopril Erbumine 4 mg
Tablet; Oral; Perindopril Erbumine 8 mg
Trezen (Romania)
Vectoryl (South Africa)
Vidotin (Poland)

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