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Pethidine

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Pethidine uses and description

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Pethidine - Pethidine is a synthetic opiate agonist belonging to the phenylpiperidine class. Pethidine may produce less smooth muscle spasm, constipation, and depression of the cough reflex than equivalent doses of morphine. The onset of action is lightly more rapid than with morphine, and the duration of action is slightly shorter. The chemical structure of meperidine is similar to local anesthetics. Pethidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Pethidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. Pethidine is considered a second-line agent for the treatment of acute pain.

Indication: Used to control moderate to severe pain.

Oral Moderate to severe acute pain

Adult: As hydrochloride: 50-150 mg every 4 hr if needed.

Child: As hydrochloride: Children 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 50-100 mg. Repeat dose every 4-6 hr if necessary.

Elderly: As hydrochloride: 50 mg every 4 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Moderate to severe acute pain

Adult: As hydrochloride: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr.

Child: As hydrochloride: SC/IM: 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 20-100 mg. Repeat dose every 4-6 hr if needed. IV inj: Neonates and children ≥12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. 12-18 yr: 25-50 mg every 4-6 hr if needed. Alternatively, ≥1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response.

Elderly: 25 mg every 4 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Obstetric analgesia

Adult: As hydrochloride: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg in 24 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Preoperative medication

Adult: As hydrochloride: 25-100 mg IM/SC given 1 hr before surgery.

Child: As hydrochloride: 1-2 mg/kg given IM 1 hr before surgery. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Postoperative pain

Adult: As hydrochloride: 25-100 mg IM/SC inj every 2-3 hr if necessary.

Child: As hydrochloride: 0.5-2 mg/kg IM every 2-3 hr if necessary. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Intravenous Adjunct to anaesthesia

Adult: As hydrochloride: 10-25 mg by slow IV inj. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Reconstitution: IV infusion: Dilute with glucose 5% or sodium chloride 0.9% to required volume. IV inj: Dilute with water for inj to a concentration of 5-10 mg/ml. Incompatibility: Y-site incompatible with idarubicin, imipenem/cilastatin, minocycline, allopurinol, amphotericin B cholesteryl sulfate complex, cefepime, cefoperazone, doxorubicin liposome. Admixture incompatibility: Aminophylline, amobarbital, floxacillin, furosemide, heparin, morphine, phenobarbital, phenytoin, thiopental, pentobarbital. Syringe incompatibility: Pentobarbital, heparin, morphine.

Oral Moderate to severe acute pain

Adult: As hydrochloride: 50-150 mg every 4 hr.

Child: As hydrochloride: Children 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 50-100 mg. Repeat dose every 4-6 hr if necessary.

Elderly: As hydrochloride: 50 mg every 4 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Moderate to severe acute pain

Adult: As hydrochloride: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr.

Child: As hydrochloride: SC/IM: Children 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 25-100 mg. Repeat dose every 4-6 hr if needed. IV inj: Neonates and children ≥12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. 12-18 yr: 25-50 mg every 4-6 hr if needed. IV inj and continuous IV infusion: Children 1 mth to 18 yr: Initially, 1 mg/kg by IV inj as a loading dose, then 100-400 mcg/kg/hr continuous IV infusion adjusted according to response.

Elderly: 25 mg every 4 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Obstetric analgesia

Adult: As hydrochloride: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg in 24 hr. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Preoperative medication

Adult: As hydrochloride: 25-100 mg IM/SC given 1 hr before surgery.

Child: As hydrochloride: 0.5-2 mg/kg IM/SC given 1 hr before surgery. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Postoperative pain

Adult: As hydrochloride: 25-100 mg IM/SC inj every 2-3 hr if necessary. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Parenteral Adjunct to nitrous oxide-oxygen anaesthesia

Adult: As hydrochloride: 10-25 mg by slow IV inj. Renal impairment: Dose reductions may be necessary. Hepatic impairment: Dose reductions may be necessary. Reconstitution: IV infusion: Dilute with glucose 5% or sodium chloride 0.9% to required volume. IV inj: Dilute with water for inj to a concentration of 5-10 mg/ml. Incompatibility: Incompatible with allopurinol, amphotericin B cholesteryl sulfate complex, cefepime, cefoperazone, doxorubicin liposome, idarubicin, imipenem/cilastatin, minocycline. Do not admix with aminophylline, amobarbital, floxacillin, furosemide, heparin, morphine, phenobarbital, phenytoin, thiopental, pentobarbital.

Indications:

Adult: PO Moderate to severe acute pain 50-150 mg 4 hrly. IV Adjunct to anesth 10-25 mg. IV/IM/SC Moderate to severe acute pain 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr. IM/SC Obstetric analgesia 50-100 mg as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg/24 hr. Pre-op medication 25-100 mg 1 hr pre-op. Post-op pain 25-100 mg 2-3 hrly if needed.

Active ingredients: Pethidine
Unit description, dosagePrice, USD
Injectable; Injection; Meperidine Hydrochloride 50 mg / ml
Injectable; Injection; Meperidine Hydrochloride 10 mg / ml
Injectable; Injection; Meperidine Hydrochloride 5%
Injectable; Injection; Meperidine Hydrochloride 25 mg / ml
PETHIDINE Injection / 50mg per ml (1ml units)$ 3.33
50 mg x 1 mL x 1mlx10$ 3.33

List of pethidine brand and generic drugs

Meperidine (Canada)
Meperidine Hydrochloride 50 mg/ml$ 0.98
Meperidine HCl 50 mg tablet$ 0.93
Demerol 50 mg/ml vial$ 0.85
Meperidine 10 mg/ml syringe$ 0.85
Meperidine 50 mg tablet$ 0.69
Demerol 50 mg/ml ampul$ 0.58
Meperidine 10 mg/ml cartrdge$ 0.30
Meperidine HCl 50 mg/5ml Solution$ 0.14
Meperidine HCl (United States)
Meperidine hydrochloride (United States)
30 milliliter in 1 vial, patent delivery system
Meperidine Hydrochloride Baxter (United States)
Meperidine Hydrochloride Sandoz (Canada)
Meperol (Argentina)
Merck-Pethidine HCl (South Africa)
Opystan (Japan)
PĆ©thidine Renaudin (France)
Pethidin Amino (Switzerland)
Pethidin HCl Bichsel (Switzerland)
Pethidin Mayne Pharma (Vietnam)
Pethidin Mayne Pharma 100 mg/2 mL x 1 hoƤp
Pethidin Streuli (Switzerland)
Pethidin-hameln (Germany)
Pethidin.Sintetica (Switzerland)
Pethidine - Shenyang No.1 Pharm (China)
Pethidine BP (Iceland)
Pethidine DBL (Hong Kong)
Pethidine HCl-Fresenius (South Africa)
Pethidine Hydrochloride BP (New Zealand)
Pethidine Injection BP (Australia, Malta, New Zealand)
Pethidine Renaudin (Tunisia)
Pethidine-DBL (Hong Kong)
Pethidini HCl PCH (Netherlands)
Petidin (Norway)
Petidin Dak (Denmark)
Petidin Ipex (Sweden)
Petidin Meda (Sweden)
Petidin SAD (Denmark)
Petidina Clorhidrato (Chile)
Petidina Cloridrato (Italy)
Petidino hidrochlorido (Lithuania)
Sabax Pethidine (South Africa)
Verpat
Verpat 50 mg Injection$ 0.83

Show all PETHIDINE generic names
 
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