Pimafucin - Pimafucin is a substance produced by the bacterium Streptomyces natalensis.
It is naturally occurring and prevents growth of yeasts and moulds, especially Candida albicans. Pimafucin binds to ergosterol, a building block in cell walls of yeasts and moulds. The Pimafucin that binds to the ergosterol causes leakage of the cell wall, leading to cell death. Bacteria do not contain ergosterol and are therefore not affected.
Indications: oral candidiasis
Indications: fungal skin and nail infections, vulvovaginal candidiasis
Indications: fungal skin and mucous membrane infections
indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. As in other forms of suppurative keratitis, initial and sustained therapy of fungal keratitis should be determined by the clinical diagnosis, laboratory diagnosis by smear and culture of corneal scrapings and drug response. Whenever possible the in vitro activity of Pimafucin against the responsible fungus should be determined. The effectiveness of Pimafucin as a single agent in fungal endophthalmitis has not been established.
Fungal diseases of skin, nails, mucous membranes, intestines, ear canal, mouth, vaginitis, vulvity, vulvovaginitis, balanoposthitis caused by the fungus Candida.