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Pituifral

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Pituifral uses and description

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Pituifral - Pharmacology: Endogenous hormone with uterine stimulant properties and vasopressive and antidiuretic effects.

Indication: Initiation or improvement of uterine contractions to achieve early vaginal delivery for maternal or fetal reasons (IV); as adjunctive therapy in the management of inevitable or incomplete abortion (IV); stimulation of uterine contractions during third stage of labor (IV); stimulation reinforcement of labor, as in selected cases of uterine inertia (IV); control of postpartum bleeding or hemorrhage (IV, IM); induction of labor in patients with a medical indication for the initiation of labor (eg, Rh problems, maternal diabetes, preeclampsia at or near term) when in the best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated (IV).

Pituifral is a natural hormone that causes the uterus to contract.

Pituifral is used to induce labor, strengthen labor contractions during childbirth, control bleeding after childbirth, or to induce an abortion.

Pituifral may also be used for purposes other than those listed in this medication guide.

Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Pituifral (BAM Biotech) promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Pituifral (BAM Biotech) has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Indication: To assist in labor, elective labor induction, uterine contraction induction

Nasal Facilitate lactation

Adult: 1 spray (4 units) into 1 nostril 5 minutes before suckling. Intravenous Adjunct in abortion

Adult: 10-20 milliunits/minute. Max total dose: 30 units in a 12-hr period. Intravenous Postpartum haemorrhage

Adult: 10-40 units by infusion in 1000 mL of IV fluid at a rate sufficient to control uterine atony. Intravenous Labour induction

Adult: 1-2 milliunits/minute, may increase at intervals of at least 30 minutes until a max of 3-4 contractions occur every 10 minutes. Not to exceed 32 milliunits/minute and no more than a total of 5 units should be given in 1 day. Not to be given within 6 hr after admin of vaginal prostaglandins. Monitor uterine contractions and foetal heart rate continuously. Withdraw gradually once labour is progressing. Intravenous Pituifral challenge test for evaluating of foetal distress

Adult: Dilute 5-10 units in 1 L of 5% dextrose inj. Initially, administer the drug in the mother via IV infusion at a rate of 0.5 milliunits/minute. May gradually increase infusion rate at intervals of 15-30 minutes. Max: 20 milliunits/minute. Monitor foetal heart rate and uterine contractions immediately before and during infusion. Discontinue infusion when 3 moderate uterine contractions occur within one 10-minute interval. Compare baseline and oxytocin-induced foetal heart rates. If no change occurs, repeat the test in 1 wk. Termination of pregnancy may be required if a late deceleration in foetal heart rate occurs. Reconstitution: Postpartum uterine bleeding: Pituifral 10-40 units to running IV infusion, max 40 units/1000 ml. Incompatibility: When admixed: fibrinolysin (human), norepinephrine, prochlorperazine edisylate, warfarin; variable compatibility with phytonadione.

Intravenous Induce abortion after rupture of membranes

Adult: 10-100 milliunits/minute via IV infusion. Max: 30 units in a 12-hr period. Intravenous Missed abortions

Adult: 10-100 milliunits/minute via IV infusion. Max: 30 units in a 12-hr period. Intravenous Prevention of postpartum haemorrhage

Adult: 5 units by slow inj followed by IV infusion of 5-30 units in 500 ml of a suitable nonhydrating diluent at a rate to control uterine atony. Intravenous Postpartum haemorrhage

Adult: 5 units by slow inj followed by IV infusion of 5-30 units in 500 ml of a suitable nonhydrating diluent at a rate to control uterine atony. Intravenous Induction of labour for medical reasons, hypotonic uterine inertia

Adult: 1-2 milliunits/minute, may increase at intervals of 30-60 min until a max of 3-4 contractions occur every 10 minutes. Max: 32 milliunits/minute and not more than 5 units in 1 day. Not to be given within 6 hr after admin of vaginal prostaglandins. Intravenous Pituifral challenge test for evaluating of foetal distress

Adult: Dilute 5–10 units in 1 L of 5% dextrose inj. Initially, administer the drug in the mother via IV infusion at a rate of 0.5 milliunits/minute. May gradually increase infusion rate at intervals of 15-30 minutes. Max: 20 milliunits/minute. Monitor foetal heart rate and uterine contractions immediately before and during infusion. Discontinue infusion when 3 moderate uterine contractions occur within one 10-minute interval. Compare baseline and oxytocin-induced foetal heart rates. If no change occurs, repeat the test in 1 wk. Termination of pregnancy may be required if a late deceleration in foetal heart rate occurs. Intramuscular Caesarean section

Adult: 10 units after delivery of the placenta. Intramuscular Prevention of postpartum haemorrhage

Adult: 5 units given with 500 mcg ergometrine maleate with or after delivery of the baby's shoulders. Nasal Facilitate lactation

Adult: 1 spray (4 units) into 1 nostril 5 minutes before suckling. Reconstitution: Postpartum uterine bleeding: Pituifral 10-40 units to running IV infusion, max 40 units/1000 ml. Incompatibility: When admixed: fibrinolysin (human), norepinephrine, prochlorperazine edisylate, warfarin; variable compatibility with phytonadione.

Initiation or improvement of uterine contractions. Antepartum Uses: Induction of labour: Induction of labour with Pituifral is indicated in term or near-term pregnancies associated with hypertension (eg, preeclampsia, eclampsia or cardiovascular-renal disease), erythroblastosis foetalis, maternal or gestational diabetes mellitus, antepartum bleeding, or preterm, premature rupture of the membranes in which spontaneous labour does not ensue. Routine induction of labour with Pituifral may be indicated in prolonged pregnancies (>42 weeks gestation). Induction of labour may also be indicated in cases of uterine foetal death, foetal growth retardation. Augmentation of labour: During the 1st and 2nd stages of labour, IV Pituifral infusion may be used to augment contractions if labour is prolonged or if dysfunctional uterine inertia occurs. Postpartum Uses: Control of postpartum bleeding and uterine hypotonicity. Other Uses: Adjunctive therapy in the management of incomplete or inevitable abortion. Diagnostic Use: To assess foetal-placental respiratory capabilities in high risk pregnancies (oxytocin challenge test).

Indications:

Adult: IV Adjunct in abortion 10-20 milliunits/min. Max total dose: 30 u in a 12-hr period. Postpartum haemorrhage 10-40 u by infusion at a rate to control uterine atony. Labour induction 1-2 milliunits/min, may increase at intervals of at least 30 mins till a max of 3-4 contractions every 10 mins. Max: 32 milliunits/min and ≤5 u/day. Not to be given w/in 6 hr after administration of vag prostaglandins. Pituifral challenge test for evaluating of foetal distress Dilute 5-10 u in 1 L of 5% dextrose inj. Initial: Drug infused in the mother via infusion at a rate of 0.5 milliunits/min. May gradually increase infusion rate. Max: 20 milliunits/min. Discontinue infusion when 3 moderate uterine contractions occur w/in one 10-minute interval. Compare baseline and oxytocin-induced foetal heart rates. Nasal Facilitate lactation Per spray contains 4 u: 1 spray into 1 nostril 5 mins before suckling.

Medical Induction of LaborTreatment of incomplete abortionTherapeutic abortionTreatment of postpartum hemorrhageDiagnosis of utero-placental insufficiency :Oxytocin is administered parent rally to assess fetal-placental respiratory capabilities in high-risk pregnancy.

Active ingredients: Oxytocin
Unit description, dosagePrice, USD

List of pituifral brand and generic drugs

Pitosol-10 (Switzerland)
Pituisan (Netherlands)
Placentol (Portugal)
Postipofisin (Italy)
Postuitrin (Turkey)
Postuitrin-Fort (Turkey)
Presoxin
PVL Oxytocin (United States)
Rotexmedica Oxytocin (Vietnam)
Rotexmedica Oxytocin 1 oáng
Roxipan (Philippines)
Roxipan (amp) 10 IU/1 mL x 1 mL x 10's$ 30.00
Santocyn (Indonesia)
Santocyn (amp) 10 IU x 1 mL x 10's$ 9.11
SAYTOCIN (India)
5 IU x 1ml$ 0.22
Saytocin 5 IU AMP / 1ml$ 0.22
Saytocin 5 iu Injection$ 0.22
Sintocin (Italy)
Solvoxine (Philippines)
Solvoxine (amp) 10 IU/1 mL x 10's$ 25.00
Synpitan (Germany, Switzerland, Turkey)
Synpitan Forte (Turkey)
Synpitan-vet (Austria)
Syntocin (Australia, Bangladesh)
Syntocinon (Argentina, Australia, Austria, Bangladesh, Belgium, Brazil, Chile, Colombia, Croatia (Hrvatska), Denmark, Ethiopia, Finland, France, Germany, Ghana, Hong Kong, Iceland, India, Indonesia, Ireland, Italy, Kenya, Libya, Luxembourg, Malaysia, Malta, Mexico, Netherlands, New Zealand, Nigeria, Norway, Peru, Philippines, Portugal, Serbia, Singapore, Slovenia, South Africa, Spain, Sudan, Sweden, Switzerland, Tanzania, Tunisia, United Kingdom, Venezuela, Zimbabwe)
Injectable; Injection; Oxytocin 5 IU / ml
Injectable; Injection; Oxytocin 10 IU / ml
Solution; Nasal; Oxytocin 40 IU / ml
Spray; Nasal; Oxytocin Oxytocin 40 IU / ml
SYNTOCINON Injection / 5 i.u. (1ml units)$ 0.47
SYNTOCINON Injection / 5 i.u. (2x5x1ml units)$ 3.07
Syntocinon 5iu/mL INJ / 5x1ml$ 1.06
Syntocinon 10 IU x 1 mL x 100's
5 IU x 1 mL x 5x1ml$ 1.06
Syntocinon 10 IU/1 mL x 10's$ 11.17
Syntocinon 10 IU/1 mL x 100's$ 106.39
Syntocinon (amp) 10 IU x 1 mL x 10's$ 47.81
Syntocinon 5 IU x 1 mL x 50 oáng
Syntocinon 5 iu Injection$ 0.57
Syntocinon (Sandoz)
Syntocinon 5IU / ml and 10IU / ml (United Kingdom)
Syntocinone
Injectable; Injection; Oxytocin 5 IU / ml
Injectable; Injection; Oxytocin 10 IU / ml
Solution; Nasal; Oxytocin 40 IU / ml
Spray; Nasal; Oxytocin Oxytocin 40 IU / ml
Syntox (Philippines)
Syntox (amp) 10 IU/1 mL x 1 mL x 100's
Tocinox (Myanmar)
Tocinox (amp) 10 IU/1 mL x 10's

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