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Prebictal

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Prebictal uses and description

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Prebictal - Prebictal is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Prebictal also affects chemicals in the brain that send pain signals across the nervous system.

Prebictal is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy) or herpes zoster (post-herpetic neuralgia).

Prebictal may also be used for purposes not listed in this medication guide.

Pharmacology: Mechanism of pregabalin's antinociceptive and antiseizure effects is unknown. Effects may be related to high affinity binding to alpha-2 delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissue.

Indication: Management of neuropathic pain associated with diabetic peripheral neuropathy; adjunctive therapy for adults with partial-onset seizures; management of postherpetic neuralgia; management of fibromyalgia.

Unlabeled Uses

Treatment of generalized anxiety disorder.

Prebictal is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Prebictal binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While Prebictal is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of Prebictal increases the density of GABA transporter protein and increases the rate of functional GABA transport. Prebictal does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Oral Postherpetic neuralgia

Adult: 75-150 mg bid. May increase up to 600 mg/day in patients with ongoing pain and can tolerate 300 mg/day. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Adjunct in partial seizures

Adult: 150-600 mg/day. Should be given in 2-3 divided doses. Max dose: 600 mg/day, Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Fibromyalgia

Adult: Initiate at 75 mg bid. May increase to 225 mg bid for patients who do not experience sufficient benefit with 300 mg/day. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Anxiety

Adult: Initiate at 150 mg daily. May increase at wkly intervals in steps of 150 mg. Max dose: 600 mg daily. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Special Populations: The dose should be adjusted in patients with reduced renal function based on creatinine clearance. CrCl of at least 60 mL/min: 50-100mg tid.

Prebictal is used to treat epilepsy (also known as seizures or fits). It is also used to relieve nerve pain in people with diabetes or shingles. Prebictal may also be used to relieve pain and discomfort in people with fibromyalgia, a condition in which there is severe fatigue and muscle aches.

Indications:

Adult: PO Postherpetic neuralgia Initial: 150 mg/day in divided doses. Usual: 150-300 mg/day in divided doses. Max: 600 mg/day in divded doses. Adjunct in partial seizures 150-600 mg/day in divided doses. Max: 600 mg/day. Fibromyalgia Initial: 150 mg/day, up to 300 mg/day after 1 wk if needed and then 450 mg/day if still needed. Anxiety Initial: 150 mg/day. Increase slowly if needed. Max: 600 mg/day.

Oral Postherpetic neuralgia

Adult: 75-150 mg bid. May increase up to 600 mg/day in patients with ongoing pain and can tolerate 300 mg/day. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Adjunct in partial seizures

Adult: 150-600 mg/day. Should be given in 2-3 divided doses. Max dose: 600 mg/day, Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Fibromyalgia

Adult: Initiate at 75 mg bid. May increase to 225 mg bid for patients who do not experience sufficient benefit with 300 mg/day. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day. Oral Generalised anxiety disorder

Adult: Initiate at 150 mg daily. May increase at wkly intervals in steps of 150 mg. Max dose: 600 mg daily. Renal impairment: Dosage adjustment is required. Patients undergoing haemodialysis should receive a supplementary dose of 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30-60 Initiate at 75 mg, max dose: 300 mg/day. 15-30 Initiate at 25-50 mg, max dose: 150 mg/day. <15 Initiate at 25 mg, max dose: 75 mg/day.

Active ingredients: Pregabalin
Unit description, dosagePrice, USD

List of prebictal brand and generic drugs

PREBAXE (India)
Prebaxe 150mg CAP / 10
Predic-GM
Predic-GM Pregabalin 75mg, Mecobalamin750mcg TAB / 10
Prega (Vietnam)
Prega 100 mg x 3 Blister x 10 Tablet
Pregab (India)
Pregab 75mg CAP / 10$ 1.64
Pregab 150mg CAP / 10$ 3.06
75 mg x 10's$ 1.64
150 mg x 10's$ 3.06
Pregaba (India)
Pregaba 75mg CAP / 10$ 1.61
Pregaba 150mg CAP / 10$ 2.78
50 mg x 10's$ 1.08
75 mg x 10's$ 1.61
150 mg x 10's$ 2.78
Pregaba 50mg CAP / 10$ 1.08
Pregaba M
Pregaba M Pregabalin 75mg,Methylcobalamin 500mcg CAP / 10$ 1.57
Pregaba Plus (India)
Pregaba Plus Pregabalin 75 mg, Mecobalamin750 mcg. CAP / 10$ 1.79
10's$ 1.79
Pregabal
Pregabal 75mg TAB / 10$ 1.50
Pregabal M
Pregabal M Pregabalin 75 g + Mecobalamin0.75 mg TAB / 10$ 2.33
Pregabalin (Vietnam)
Lyrica 100 mg capsule$ 2.88
Lyrica 150 mg capsule$ 2.88
Lyrica 50 mg capsule$ 2.88
Lyrica 75 mg capsule$ 2.88
Lyrica 200 mg capsule$ 2.75
Lyrica 225 mg capsule$ 2.75
Lyrica 25 mg capsule$ 2.75
Lyrica 300 mg capsule$ 2.75
Pregabanyl
Pregabanyl Pregabalin 75g + Mecobalamin0.75mg CAP / 10$ 2.41
Pregaben (Bangladesh)
Pregabid (India)
Pregabid Capsule/ Tablet / 150mg (10 units)$ 2.48
Pregabid Capsule/ Tablet / 300mg (10 units)$ 4.37
Pregabid Capsule/ Tablet / 75mg (10 units)$ 1.37
50 mg x 10's
75 mg x 10's$ 1.37
Pregabid 80mg CAP / 10
Pregabid 75mg CAP / 10$ 1.37
PREGABID-OD (India)
100 mg x 10's$ 1.70
150 mg x 10's
Pregabid-OD 100mg SR-FC-TAB / 10$ 1.70
Pregabid-OD 150mg SR-FC-TAB / 10
Pregabin (India)
Pregabin 75mg TAB / 10$ 1.26
Pregabin 150mg TAB / 10$ 2.56
75 mg x 10's$ 1.26

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