Prenolol - Prenolol is a cardioselective beta1-blocker without intrinsic sympathomimetic activity. This medication has antihypertensive, antianginal and antiarrhythmic action. Prenolol reduces the stimulatory effect on the heart sympathetic innervation and circulating catecholamines.
The hypotensive effect of this drug is associated with a decrease in minute volume of blood, decreased activity of the renin-angiotensin system (has a greater significance for patients with initial hypersecretion of renin), sensitivity of baroreceptors of the aortic arch (not going to enhance their activity in response to decreased blood pressure) and the effect on the CNS; manifested lower both systolic and diastolic blood pressure, decreasing stroke volume and cardiac output. In the medium therapeutic doses it has no effect on the tone of peripheral arteries.
The antianginal effect of Prenolol is associated with decreased myocardial oxygen demand by decreasing heart rate (lengthening of diastole and improved myocardial perfusion) and contractility, as well as reduced sensitivity to the effects of myocardial sympathetic innervation. Decrease in heart rate occurs at rest and during exercise.
The antiarrhythmic effect of this medicine is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increase of cAMP, hypertension), decrease in the rate of spontaneous excitation of the sinus and ectopic pacemakers and slowing of AV conduction.
The hypotensive effect lasts 24 hours, with regular admission is stabilized by the end of 2 weeks of treatment. The negative chronotropic effect is manifested by 1 h after administration, reaches a maximum after in 2-4 hours and lasts up to 24 hours.
Prenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, Prenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Prenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Indication: For the management of hypertention and long-term management of patients with angina pectoris
Prenolol helps to keep your blood pressure under control. It may also be used to treat certain heart diseases such as angina pectoris (chest pain) and arrhythmia (irregular heart beats). Prenolol is also used to reduce the risk of heart complications after a heart attack. Prenolol may also be used to relieve palpitations (fast and irregular heartbeats) commonly experienced by people with an overactive thyroid gland.
Hypertension, angina pectoris & cardiac dysrhythmia.