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Presartan GMP

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Presartan GMP uses and description

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Presartan GMP - Used for: Treating high blood pressure alone or with other medicines. It is used in certain patients to decrease the risk of stroke. It is used in certain patients to treat kidney problems caused by diabetes (diabetic nephropathy). It may also be used for other conditions as determined by your doctor.

Presartan GMP is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels. This helps to lower blood pressure.

Presartan GMP is in a group of drugs called angiotensin II receptor antagonists. Presartan GMP keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Presartan GMP is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Presartan GMP is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Presartan GMP may also be used for other purposes not listed in this medication guide.

Presartan GMP is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Presartan GMP and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS). RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: AT1 and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.

Oral Hypertension

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Child: ≥6 yr: Initially 700 mcg/kg increased to a maximum of 50 mg once daily if needed.

Elderly: >75 yr: Initally, 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially, 25 mg once daily Oral Diabetic nephropathy in Type 2 diabetes mellitus

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Elderly: >75: Initially 25 mg once daily. Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially 25 mg once daily. Special Populations: Patients with intravascular fluid depletion: Initially, 25 mg once daily.

Presartan GMP helps to keep your blood pressure under control. Presartan GMP relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Presartan GMP may also be used to treat other conditions, for example, heart failure and kidney disease in diabetic patients with high blood pressure.

Indications:

Adult: PO HTN; Diabetic nephropathy in Type 2 DM 50 mg once daily. Max: 100 mg/day.

Oral Hypertension

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Child: ≥6 yr: Initially 700 mcg/kg increased to a maximum of 50 mg once daily if needed.

Elderly: >75 yr: Initally, 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially, 25 mg once daily Oral Diabetic nephropathy in Type 2 diabetes mellitus

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Elderly: >75: Initially 25 mg once daily. Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially 25 mg once daily. Special Populations: Patients with moderate to severe renal impairment (CrCl <20 mL/min) or intravascular fluid depletion: Initially, 25 mg once daily. Reduce dose in hepatic impairment.

Active ingredients: Losartan
Unit description, dosagePrice, USD

List of presartan gmp brand and generic drugs

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Psycholanz (Myanmar)
PSYCHOLANZ Capsule/ Tablet / 5mg (10 units)$ 0.44
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PSYCHOLANZ Capsule/ Tablet / 10mg (10 units)$ 0.88
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PSYCHOLANZ Capsule/ Tablet / 2.5mg (10 units)$ 0.26
Rabolan (Greece)
Ranlozar (Bulgaria)
Rapifast (Greece)
Rasart 100
Rasertan (Ecuador)
Rasoltan (Bulgaria, Georgia, Hungary, Poland)
Redupress
Renicard
Tablet, Film-Coated; Oral; Losartan Potassium 25 mg
Tablet, Film-Coated; Oral; Losartan Potassium 50 mg
Repace H (Vietnam)
Repace H 50 mg x 1 ho├Ąp
Resilo (Peru, Sri Lanka, Vietnam)
Resilo 25 mg x 2 Blister x 10 Tablet
Resilo 25 mg x 10 Blister x 10 Tablet
Resilo 50 mg x 2 Blister x 10 Tablet
Resilo 50 mg x 10 Blister x 10 Tablet
Resilo 25mg TAB / 10$ 0.46
Resilo 50mg TAB / 10$ 0.74
25 mg x 10's$ 0.46
50 mg x 10's$ 0.74
RIGARD (India)
25 mg x 10's$ 0.39
50 mg x 10's$ 0.72
Rigard 25mg TAB / 10$ 0.39
Rigard 50mg TAB / 10$ 0.72
Rosa (South Korea)
Rosarzen (South Korea)
Rosastar (South Korea)
Rosatan (Bangladesh)
Rosatan CJ (South Korea)
Rotamax (South Korea)
Sanipresin
Tablet; Oral; Losartan Potassium 50 mg
Sanipresin Forte (Chile)
Sarilen (Turkey)
Sarlo (Bangladesh)
Sarlotan (South Korea)

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