Primalan - In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Primalan is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Indication: For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Indications: hypersensitivity reactions
Indications: hypersensitivity reactions, pruritus
Allergic rhinitis, hay fever, periodic rhinitis, urticaria, pruritus, eczema, Quincke’s edema, seasonal conjunctivitis, reactions during desensitization, prophylaxis for asthma.