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RHu GM-CSF

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RHu GM-CSF uses and description

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RHu GM-CSF - Used for: Reducing severe, life-threatening, or fatal infections after chemotherapy for acute myelogenous leukemia (AML). It is also used to help increase the success of autologous bone marrow transplant and to help increase survival in patients who have bone marrow transplant failure. It may also be used for other conditions as determined by your doctor.

RHu GM-CSF is a hematopoietic agent. It works by stimulating production of white blood cells in bone marrow.

Pharmacology: Supports survival, proliferation, and differentiation of hematopoietic progenitor cells; induces partially committed progenitor cells to divide and differentiate in granulocyte-macrophage pathways; activates mature granulocytes and macrophages; promotes proliferation of megakaryocytic and erythroid progenitors.

Indication: Myeloid reconstitution after autologous bone marrow transplantation and after bone marrow transplantation failure or graft failure; promotion of early engraftment or engraftment delay; treatment of neutropenia associated bone marrow transplant; induction chemotherapy in acute myelogenous leukemia (AML); mobilization and following transplantation of autologous PBPC; and myeloid reconstitution after allogeneic BMT.

Unlabeled Uses

Increase WBC counts in patients with myelodysplastic syndromes and in AIDS patients receiving zidovudine; decrease nadir of leukopenia secondary to myelosuppressive chemotherapy; decrease myelosuppression in preleukemic patients; correct neutropenia in aplastic anemia patients; decrease transplantation-associated organ system damage.

RHu GM-CSF is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

RHu GM-CSF is used to increase white blood cells and help prevent serious infection in conditions such as leukemia, bone marrow transplant, and pre-chemotherapy blood cell collection. RHu GM-CSF is for use in adults who are at least 55 years old.

RHu GM-CSF may also be used for purposes not listed in this medication guide.

Intravenous Chemotherapy-induced neutropenia

Adult: 250 mcg/m 2 daily for up to 42 days as required, to be given as IV infusion over 4 hr. Intravenous Bone marrow transplantation

Adult: 250 mcg/m 2 daily by IV infusion over 2 hr. If engraftment is delayed or has failed, a 14-day course at 250 mcg/m 2 daily may be given. Course may be repeated after a 7-day interval if engraftment has not occurred. A 3rd course at 500 mcg/m 2 /day may be given for 14 days after another 7-day interval, if needed. Further dose increment may not be beneficial. Parenteral Mobilisation of peripheral blood progenitor cells

Adult: 250 mcg/m 2 daily by continuous IV infusion over 24 hr or once daily by SC inj with leucapheresis usually starting on day 5 and continued daily until protocol specified targets are reached. Reduce dose by half if WBC>50,000 cells/mm 3. Consider other mobilisation therapy if the numbers of progenitor cells that are collected are inadequate.

Intravenous Treatment and prevention of neutropenia in patients receiving myelosuppressive chemotherapy

Adult: 250 mcg/m 2 daily for up to 42 days as required, to be given as IV infusion over 4 hr. Intravenous Reduce neutropenia after bone marrow transplantation

Adult: 250 mcg/m 2 daily by IV infusion over 2 hr. If engraftment is delayed or has failed, a 14-day course at 250 mcg/m 2 daily may be given. Course may be repeated after a 7-day interval if engraftment has not occurred. A 3rd course at 500 mcg/m 2 /day may be given for 14 days after another 7-day interval, if needed. Further dose increment may not be beneficial. Parenteral Mobilisation of peripheral blood progenitor cells after cytotoxic chemotherapy

Adult: 250 mcg/m 2 daily by continuous IV infusion over 24 hr or by SC inj.

Indications:

Adult: IV Chemotherapy-induced neutropenia 250 mcg/m 2 /day for ≤42 days as needed. Bone marrow transplantation 250 mcg/m 2 /day. If engraftment is delayed or has failed, a 14-day course at 250 mcg/m 2 /day may be given. May repeat course after a 7-day interval if engraftment has not occurred. A 3rd course at 500 mcg/m 2 /day may be given after another 7-day interval if needed. IV/SC Mobilisation of peripheral blood progenitor cells 250 mcg/m 2 /day.

Active ingredients: Sargramostim
Unit description, dosagePrice, USD

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