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Ramoril

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Ramoril uses and description

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Ramoril - Used for: Treating high blood pressure or decreasing the risk of heart attack, stroke, and death in certain patients. It may be used alone or with other medicines. It is used along with other medicines to manage heart failure and improve survival after a heart attack. It may also be used for other conditions as determined by your doctor.

Ramoril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

Pharmacology: Competitively inhibits angiotensin I-converting enzyme, resulting in prevention of angiotensin I conversion to angiotensin II, a potent vasoconstrictor. Clinical consequences include decrease in BP and indirect (by inhibiting aldosterone) decrease in sodium and fluid retention and increase in diuresis.

Indication: Treatment of hypertension; for stable patients who have demonstrated clinical signs of CHF within the first few days after sustaining acute MI; reduce risk of MI, stroke, or death from CV causes in patients at high risk.

Ramoril is an ACE inhibitor similar to benazepril, fosinopril and quinapril. It is an inactive prodrug that is converted to ramiprilat in the liver, the main site of activation, and kidneys. Ramiprilat confers blood pressure lowing effects by antagonizing the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may sustain the effects of ramiprilat by causing increased vasodilation and decreased blood pressure.

Ramoril helps to keep your blood pressure under control. Ramoril relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Ramoril may also be used to treat other conditions, for example, heart failure.

Oral Hypertension

Adult: Initially, 1.25 mg once daily given at bedtime.

Maintenance: 2.5-5 mg daily as a single dose, up to 10 mg daily as needed. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral Heart failure

Adult: Initially, 1.25 mg once daily. Max dose: 10 mg daily. Doses ≥2.5 mg may be given in 2 divided doses. Max

Dosage: 10 mg daily in 1-2 divided doses. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral Post myocardial infarction

Adult: Initially, 2.5 mg bid increased after 2 days to 5 mg bid. Start treatment 3-10 days after infarction. Usual dose: 2.5-5 mg bid. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral Prophylaxis of cardiovascular events in high-risk patients

Adult: Initially, 2.5 mg once daily increased to 5 mg once daily after 1 wk if tolerated.

Maintenance: 10 mg once daily after a further 3 wk. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Special Populations: Reduce dose in patients with renal impairment.

Oral hypertension

Adult: Initially, 1.25 mg once daily given at bedtime.

Maintenance: 2.5-5 mg daily as a single dose, up to 10 mg daily as needed. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral heart failure

Adult: Initially, 1.25 mg once daily. Max dose: 10 mg daily. Doses ≥2.5 mg may be given in 2 divided doses. Max

Dosage: 10 mg daily in 1-2 divided doses. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral MI

Adult: Initially, 2.5 mg bid increased after 2 days to 5 mg bid. Start treatment 3-10 days after infarction. Usual dose: 2.5-5 mg bid. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initiate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily. Oral Prophylaxis of CV events in high-risk patients

Adult: Initially, 2.5 mg once daily increased to 5 mg once daily after 1 wk if tolerated.

Maintenance: 10 mg once daily after a further 3 wk. CrCl (ml/min) Dosage Recommendation 10-30 Initiate with 1.25 mg once daily. Max dose: 5 mg daily. <10 Initate with 1.25 mg once daily. Max dose: 2.5 mg daily. Hepatic impairment: Initiate with 1.25 mg once daily.

Indications:

Adult: PO HTN Initial: 1.25 mg at bedtime.

Maintenance: 2.5-5 mg/day as a single dose, up to 10 mg/day if needed. Heart failure Initial: 1.25 mg once daily. Max: 10 mg/day. MI Start 3-10 days after infarction. Initial: 2.5 mg twice daily after 2 days, then 5 mg twice daily.

Maintenance: 2.5-5 mg twice daily. Prophylaxis of CV events in high-risk patients Initial: 2.5 mg once daily for 1 wk, then increased if tolerated to 5 mg once daily for 3 wk, then

Maintenance: 10 mg once daily.

Active ingredients: Ramipril
Unit description, dosagePrice, USD

List of ramoril brand and generic drugs

RAMM (India)
Ramm 2.5mg TAB / 10
Ramp 2.5
Ramp 5
Rampil (South Africa)
RAMPRIL (India)
RAMPRIL Capsule/ Tablet / 2.5mg (10 units)$ 0.63
RAMPRIL Capsule/ Tablet / 5mg (10 units)$ 1.04
RAMPRIL Capsule/ Tablet / 10mg (10 units)$ 1.65
RAMPRIL Capsule/ Tablet / 1.25mg (10 units)$ 0.33
1.25 mg x 10's$ 0.33
2.5 mg x 10's$ 0.63
5 mg x 10's$ 1.04
10 mg x 10's$ 1.65
Rampril 1.25mg CAP / 10$ 0.33
Rampril 2.5mg CAP / 10$ 0.63
Rampril 5mg CAP / 10$ 1.04
Rampril 10mg CAP / 10$ 1.65
Ramsho (India)
Ramsho 1.25mg TAB / 10$ 0.35
Ramsho 2.5mg TAB / 100$ 0.63
Ramsho 5mg TAB / 10$ 1.05
1.25 mg x 10's$ 0.35
2.5 mg x 10's$ 0.63
5 mg x 10's$ 1.05
RAMSHO-H (India)
10's$ 0.73
Ramsho-H Ramipril 2.5 mg,Hydrochlorothiazide 12.5 mg. TAB / 10$ 0.73
Ramtace (Thailand)
Ramtace 2.5 mg x 10 x 10's
Ramtace 5 mg x 10 x 10's
Ramtace 10 mg x 10's
Ramtace 10 mg x 10 x 10's
RAMVAS (India)
1.25 mg x 10's$ 0.37
2.5 mg x 10's$ 0.67
5 mg x 10's$ 1.24
Ramvas 1.25mg CAP / 10$ 0.37
Ramvas 2.5mg CAP / 10$ 0.67
Ramvas 5mg CAP / 10$ 1.24
Ramve (Poland)
Ramyte (Ireland)
RAMZE (India)
2.5 mg x 150's$ 11.11
Ramze 2.5mg TAB / 150$ 11.11
Ran-Ramipril (South Africa)
Capsule; Oral; Ramipril 1.25 mg
Capsule; Oral; Ramipril 10 mg
Capsule; Oral; Ramipril 2.5 mg
Capsule; Oral; Ramipril 5 mg

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