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Restatin

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Restatin uses and description

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Restatin - Restatin is an antifungal medication.

Oral Restatin is used to treat yeast infections of the mouth.

Restatin may also be used for purposes other than those listed in this medication guide.

Pharmacology: Binds to fungal cell membrane, changing membrane permeability and allowing leakage of intracellular components.

Indication: Treatment of intestinal, oral, vulvovaginal, cutaneous, or mucocutaneous candidiasis.

Restatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Restatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to Restatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with Restatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Restatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

Nystatin belongs to a group of polyolefinic antimycotic antibiotics which are highly effective against yeast-like Candida fungi. The antibiotic possesses a double bond which exerts high level of affinity to the phytosterole structures of the fungal cell membrane, which in turn promotes formation of a channels which start the uncontrolled transport of electrolytes through the membrane cell increase in osmolarity leads to fungal cell death. Resistance for nystatin is formed slowly.

Indications:

  • Hypersensitivity to any components of the preparation
  • Bacterial and viral infections without subsidiary treatment

  • Restatin is an antifungal medicine. It is used to treat fungal infections of the mouth and digestive system.

    Oral Intestinal or oropharyngeal candidiasis

    Adult: 500,000 or 1,000,000 units 3-4 times daily.

    Child: As oral suspension: 100,000 units 4 times daily. Oral Oral candidiasis

    Adult: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed.

    Child: >1 mth: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed. Oral Prophylaxis of intestinal candidiasis

    Adult: 1,000,000 units daily in divided doses.

    Child: Infants, as oral suspension: 100,000 units daily. Vaginal Vaginal candidiasis

    Adult: 100,000-200,000 units daily for 14 days as pessaries or vaginal cream. Topical/Cutaneous Cutaneous or mucocutaneous mycotic infections

    Adult: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily.

    Child: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily. Special Populations: Higher doses may be required in immunocompromised patients.

    Oral Intestinal or oropharyngeal candidiasis

    Adult: 500,000 or 1,000,000 units 3-4 times daily.

    Child: As oral suspension: 100,000 units 4 times daily. Oral Oral candidiasis

    Adult: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed.

    Child: >1 mth: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed. Oral Prophylaxis of intestinal candidiasis

    Adult: 1,000,000 units daily in divided doses.

    Child: Infants, as oral suspension: 100,000 units daily. Vaginal Vaginal candidiasis

    Adult: 100,000-200,000 units daily for 14 days as pessaries or vaginal cream. Topical/Cutaneous Cutaneous or mucocutaneous mycotic infections caused by susceptible Candida species

    Adult: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily.

    Child: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily. Special Populations: Higher doses may be required in immunocompromised patients.

    Indications:

    Adult: PO Intestinal or oropharyngeal candidiasis 500,000 or 1,000,000 u 3-4 times/day. Oral candidiasis As pastilles or oral susp: 100,000 u 4 times/day. Continue for 48 hr after lesions have healed. Prophylaxis of intestinal candidiasis 1,000,000 u/day in divided doses. Vag Vag candidiasis As pessaries/vag cream: 100,000-200,000 u/day for 14 days. Topical Susceptible fungal infections Per g cream/gel/oint/dusting powd contains 100,000 u/g: Apply 2-4 times/day.

    Active ingredients: Nystatin
    Unit description, dosagePrice, USD

    List of restatin brand and generic drugs

    Nystop (United States)
    30 gram in 1 bottle, plastic
    60 gram in 1 bottle, plastic
    O-V Statin
    Orastin (Philippines)
    Orastin 100000 IU/1 mL x 12 mL
    Pedi-Dri (United States)
    Pharmastatin (Slovakia, United States)
    PMS Nystatin
    PMS-Nystatin (Singapore)
    Suspension; Oral; Nystatin 100,000 units / ml
    PMS-Nystatin 100000 u/1 mL x 48 mL x 1's
    PMS-Nystatin 100000 u/1 mL x 100 mL x 1's
    ratio-Nystatin (Canada)
    Cream; Topical; Nystatin 100,000 units / g
    Drops; Oral; Nystatin 100,000 units / ml
    Ointment; Topical; Nystatin 100,000 units / g
    Tablet; Oral; Nystatin 100,000 units
    Tablet; Oral; Nystatin 500,000 units
    Rianest (Oman)
    Rivostatin
    Romalina
    Sanitatin (Taiwan)
    Sanitatin 100000 IU x 1000's
    Sodium nystatin
    Stamicin (Romania)
    Stamycin
    Sterostatine
    Supofun (Vietnam)
    Supofun 100000 IU x 1 Blister x 7 Tablet
    Supofun 100000 IU x 2 Blister x 7 Tablet
    T.G.B. (Taiwan)
    T.G.B. 100000 u/1 g x 1 g
    T.G.B. 100000 u/1 g x 5 g
    T.G.B. 100000 u/1 g x 6 g
    T.G.B. 100000 u/1 g x 10 g
    T.G.B. 100000 u/1 g x 12 g
    T.G.B. 100000 u/1 g x 15 g
    T.G.B. 100000 u/1 g x 16 g
    T.G.B. 100000 u/1 g x 20 g
    Terrastatin
    Tinaderm M
    Tinaderm M Skin 10 gm Cream$ 0.06
    Tricocet
    Trinizina (Mexico)
    Tystatin (Myanmar)
    Tystatin 100000 u/1 mL x 12 mL
    Unguentum Nystatinum (Georgia)
    Uphastatin (Malaysia)
    Uphastatin 100000 u x 30 g
    Zydin E

    Show all Restatin generic names
     
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