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Satoren

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Satoren uses and description

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Satoren - Used for: Treating high blood pressure alone or with other medicines. It is used in certain patients to decrease the risk of stroke. It is used in certain patients to treat kidney problems caused by diabetes (diabetic nephropathy). It may also be used for other conditions as determined by your doctor.

Satoren is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels. This helps to lower blood pressure.

Satoren is in a group of drugs called angiotensin II receptor antagonists. Satoren keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Satoren is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Satoren is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Satoren may also be used for other purposes not listed in this medication guide.

Satoren is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Satoren and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS). RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: AT1 and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.

Oral Hypertension

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Child: ≥6 yr: Initially 700 mcg/kg increased to a maximum of 50 mg once daily if needed.

Elderly: >75 yr: Initally, 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially, 25 mg once daily Oral Diabetic nephropathy in Type 2 diabetes mellitus

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Elderly: >75: Initially 25 mg once daily. Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially 25 mg once daily. Special Populations: Patients with intravascular fluid depletion: Initially, 25 mg once daily.

Satoren helps to keep your blood pressure under control. Satoren relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Satoren may also be used to treat other conditions, for example, heart failure and kidney disease in diabetic patients with high blood pressure.

Indications:

Adult: PO HTN; Diabetic nephropathy in Type 2 DM 50 mg once daily. Max: 100 mg/day.

Oral Hypertension

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Child: ≥6 yr: Initially 700 mcg/kg increased to a maximum of 50 mg once daily if needed.

Elderly: >75 yr: Initally, 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially, 25 mg once daily Oral Diabetic nephropathy in Type 2 diabetes mellitus

Adult: 50 mg once daily, increased to 100 mg daily as a single dose or in 2 divided doses if needed.

Elderly: >75: Initially 25 mg once daily. Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily. CrCl (ml/min) Dosage Recommendation <20 Initially 25 mg once daily. Hepatic impairment: Initially 25 mg once daily. Special Populations: Patients with moderate to severe renal impairment (CrCl <20 mL/min) or intravascular fluid depletion: Initially, 25 mg once daily. Reduce dose in hepatic impairment.

Active ingredients: Losartan
Unit description, dosagePrice, USD

List of satoren brand and generic drugs

Sarve (Poland)
Sedeten (Chile)
Simperten (Chile)
Tablet; Oral; Losartan Potassium 50 mg
Sortal (Venezuela)
Sortiva (Oman)
Sortiva Forte (Oman)
Stadazar (Poland)
Tacardia (Argentina)
Tacicul (Argentina)
Talosan (Romania)
Tarnasol (Estonia, Lithuania, Slovakia)
Temisartan (Argentina)
Tenopres
Tensaar (Indonesia)
Tensartan (Colombia)
Tenserpil
Tensiohess (El Salvador)
Tensivel (Chile)
Tervalon (Argentina, Hungary)
Tiasar (Portugal)
Torlós (Brazil)
Torlos
Tozaar (Myanmar)
Tozaar Capsule/ Tablet / 25mg (10 units)$ 0.66
Tozaar Capsule/ Tablet / 50mg (10 units)$ 1.17
25 mg x 10's$ 0.48
50 mg x 10's$ 1.17
Tozaar 25mg TAB / 10$ 0.48
Tozaar 50mg TAB / 10$ 1.17
Tozaar 25 mg Tablet$ 0.07
Tozaar 50 mg Tablet$ 0.12
Vasotan (Bangladesh)
Vasotenz (Russian Federation)
Vazotenz
Tablet, Film-Coated; Oral; Losartan Potassium 100 mg
Tablet, Film-Coated; Oral; Losartan Potassium 12.5 mg
Tablet, Film-Coated; Oral; Losartan Potassium 25 mg
Tablet, Film-Coated; Oral; Losartan Potassium 50 mg
Vida (India)
Vida 25 (India)
Vida 25 25mg FC-TAB / 10$ 0.44
Vida 25 50mg FC-TAB / 10$ 0.89
25 mg x 10's$ 0.44
50 mg x 10's$ 0.89
Wonsartan (South Korea)

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