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Silverzine

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Silverzine uses and description

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Silverzine - Pharmacology: Exerts bacteriostatic action by competing with PABA, an essential component in folic acid synthesis, therefore preventing synthesis of folic acid needed by bacteria for growth.

Indication: Treatment of chancroid, trachoma, inclusion conjunctivitis, nocardiosis, UTI, toxoplasmosis encephalitis, malaria, meningococcal meningitis, acute otitis media; prophylaxis against meningococcal meningitis and recurrences of rheumatic fevers; with streptomycin as adjunctive therapy for Haemophilus influenza meningitis.

Take all of the Silverzine that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

Used for: Treating and preventing certain bacterial infections.

Silverzine is a sulfonamide antibiotic. It works by inhibiting the growth and replication of bacteria.

Silverzine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Oral Infections caused by susceptible pathogens

Adult: Initially, 2-4 g/day. May increase up to 6 g/day, given in divided doses.

Child: Start with 75 mg/kg, subsequently, 150 mg/kg in divided doses. Max: 6 g/day. Renal impairment: Dosage reduction may be necessary. Oral Prophylaxis of rheumatic fever in children

Child: <30 kg: 0.5 g every 24 hr; >30 kg: 1 g/day. Renal impairment: Dosage reduction may be necessary. Oral Nocardiosis

Adult: 4-8 g daily for at least 6 wk. May continue for many mth to prevent relapse of infection. Renal impairment: Dosage reduction may be necessary. Oral Prophylaxis of meningococcal infections

Adult: 1 g bid for 2 days.

Child: 2-12 mth: 500 mg once daily for 2 days; 1-12 yr: 500 mg bid for 2 days. Renal impairment: Dosage reduction may be necessary. Oral Toxoplasmosis

Adult: Including immunocompromised patients: 4-6 g/day in 4 divided doses for at least 6 wk. Subsequently, 2-4 g/day, to be continued indefinitely.

Child: For congenital toxoplasmosis: <2 mth: 50 mg/kg bid for 12 mth. Renal impairment: Dosage reduction may be necessary. Oral Prevention of toxoplasmosis in patients with HIV infection

Adult: 0.5-1 g every 6 hr, to be taken with oral pyrimethamine (25-50 mg daily) and oral leucovorin (10-25 mg/day).

Child: 85-120 mg/kg/day, given in 2-4 divided doses with oral pyrimethamine (1 mg/kg/day; max: 25 mg/day) and oral leucovorin (5 mg once every 3 days). Renal impairment: Dosage reduction may be necessary.

Oral Susceptible infections

Adult: Initially, 2-4 g/day. May increase up to 6 g/day, given in divided doses.

Child: Start with 75 mg/kg, subsequently, 150 mg/kg in divided doses. Max: 6 g/day. Renal impairment: Dosage reduction may be necessary. Oral Prophylaxis of rheumatic fever

Adult: >30 kg: 1 g once daily; <30 kg: 500 mg once daily.

Child: <30 kg: 0.5 g every 24 hr; >30 kg: 1 g/day. Renal impairment: Dosage reduction may be necessary. Oral Nocardiosis

Adult: 4-8 g daily for at least 6 wk. May continue for many mth to prevent relapse of infection. Renal impairment: Dosage reduction may be necessary. Oral Toxoplasmosis

Adult: Including immunocompromised patients: 4-6 g/day in 4 divided doses for at least 6 wk. Subsequently, 2-4 g/day, to be continued indefinitely.

Child: For congenital toxoplasmosis: <2 mth: 50 mg/kg bid for 12 mth. Renal impairment: Dosage reduction may be necessary. Oral Prophylaxis of toxoplasmosis in patients with HIV infection

Adult: 0.5-1 g every 6 hr, to be taken with oral pyrimethamine (25-50 mg daily) and oral leucovorin (10-25 mg/day).

Child: 85-120 mg/kg/day, given in 2-4 divided doses with oral pyrimethamine (1 mg/kg/day; max: 25 mg/day) and oral leucovorin (5 mg once every 3 days). Renal impairment: Dosage reduction may be necessary.

Indications:

Adult: PO Susceptible infections Initial: 2-4 g/day, up to 6 g/day in divided doses. Prophylaxis of rheumatic fever >30 kg: 1 g once daily; <30 kg: 500 mg once daily. Nocardiosis 4-8 g/day for ≥6 wk. Prophylaxis of meningococcal infections 1 g twice daily for 2 days. Toxoplasmosis 4-6 g/day in 4 divided doses for ≥6 wk, then continue w/ 2-4 g/day indefinitely. Prevention of toxoplasmosis in patients w/ HIV infection 0.5-1 g 6 hrly w/ oral pyrimethamine and oral leucovorin.

Active ingredients: Sulfadiazine
Unit description, dosagePrice, USD

List of silverzine brand and generic drugs

Silvertone (Switzerland)
Cream; Topical; Silver Sulfadiazine 1%
Silvin (Ethiopia)
Silvin 50 g x 1's
Silvin 500 g x 1's
Sofargen (Italy)
Spofadrizine
SSD (United States)
Cream; Topical; Silver Sulfadiazine 1%
SSZ Aplicaps (India)
SSZ Aplicaps Eye 1% Aplicaps$ 0.01
Sterazine
Sterizole (Philippines)
Sularyn
Sulfa - D (Peru)
Sulfa-Triple
Sulfacol Sandoz (Colombia)
Sulfacombin
Sulfadiazin
Tablet; Oral; Sulfadiazine 500 mg
Sulfadiazin Streuli (Switzerland)
Sulfadiazin-Heyl (Germany)
Sulfadiazina de plata (Colombia, Venezuela)
Sulfadiazina de Plata Gen-Far (Peru)
Sulfadiazina de Plata Genfar (Colombia, Ecuador)
Sulfadiazina de Plata La Santé (Colombia)
Sulfadiazina L.CH. (Chile)
Sulfadiazina Reig Jofre (Spain)
Sulfadiazina Vannier (Argentina)
Sulfadiazinac
Sulfadiazine (Finland)
Injectable; Injection; Sulfadiazine Sodium 250 mg / ml
Tablet; Oral; Sulfadiazine 500 mg
Tablet; Oral; Sulfadiazine 300 mg
Silver Sulfadiazine 1% Cream 400 gm Jar$ 36.48
Silver Sulfadiazine 1% Cream 50 gm Jar$ 21.99
Silver Sulfadiazine 1% Cream 85 gm Jar$ 19.99
Silver Sulfadiazine 1% Cream 25 gm Jar$ 13.99
Sulfadiazine 500 mg tablet$ 2.50
Sulfazine EC 500 mg Enteric Coated Tabs$ 0.42
Sulfazine ec 500 mg tablet$ 0.38
Sulfazine 500 mg tablet$ 0.25
Sulfadiazine powder$ 0.13
Sulfadiazine (Shinlon) 500 mg x 1000's
Sulfadiazine A.N.H. (Thailand)
Sulfadiazine A.N.H. 500 mg x 500's
Sulfadiazine A.N.H. 500 mg x 1,000's
Sulfadiazine Chew Brothers (Thailand)
Sulfadiazine Chew Brothers 500 mg x 500's
Sulfadiazine Chew Brothers 500 mg x 1000's

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