Simcor - Used for: Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It may also be used for other conditions as determined by your doctor.
Simcor is an HMG-CoA reductase inhibitor and niacin combination. The HMG-CoA reductase inhibitor works by reducing the production of certain fatty substances in the body, including cholesterol. The niacin works by reducing low-density lipoprotein (LDL, "bad") cholesterol and triglycerides and increasing HDL cholesterol.
Niacin, also called nicotinic acid, is a B vitamin (vitamin B3). It occurs naturally in plants and animals, and is also added to many foods as a vitamin supplement. Niacin is also present in many multiple vitamins and nutritional supplements.
Simcor is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simcor reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
The combination of niacin and Simcor is used to lower cholesterol and triglycerides (types of fat) in the blood.
Niacin and Simcor may also be used for purposes not listed in this medication guide.
Simcor is a hypolipidemic agent from a group of statins, an inhibitor of HMG-CoA reductase. This medication is a prodrug because it has in its structure the closed lactone ring which is hydrolyzed after intake.
Lipid-lowering effect of statins is associated with lower levels of total cholesterol by LDL-C. Reducing cholesterol is dose-dependent and is not linear but exponential. Statins do not affect the activity of lipoprotein and hepatic lipase, have no significant effect on the synthesis and catabolism of free fatty acids, thats why their effect on TG levels again and indirectly through their main effects on reducing LDL-C.
According to the controlled studies of Simcor increases HDL-C to 14%.
In addition to the hypolipidemic actions Simcor has beneficial effects in endothelial dysfunction (pre-clinical sign of early atherosclerosis), on the vascular wall, the state of atheroma, improves blood rheology, have antioxidant, antiproliferative properties. There is evidence that Simcor improves endothelial function within 30 days of therapy.
Simcor therapy was accompanied by a decrease in the incidence of cardiovascular disorders, regardless of baseline LDL-C.
Simcor is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body.
The combination of niacin and Simcor is used to lower cholesterol and triglycerides (types of fat) in the blood. Lowering your cholesterol and triglycerides can help prevent heart disease and coronary artery disease (also called atherosclerosis), conditions that can lead to heart attack, stroke, and vascular disease.
Therapy with lipid-altering agents should be onlyone component of multiple risk factor intervention in individualsat significantly increased risk for atherosclerotic vascular diseasedue to hypercholesterolemia. Drug therapy is indicated as an adjunctto diet when the response to a diet restricted in saturated fat andcholesterol and other nonpharmacologic measures alone has been inadequate. Patientswith Hypercholesterolemia Requiring Modifications of Lipid Profiles SIMCOR
Simcor helps lower your cholesterol level. Excessive cholesterol in your body can clog up your blood vessels. This can lead to many health problems such as strokes and heart disease, including heart attacks. Simcor is meant to be taken as part of a complete cholesterol management programme that should include exercise, a healthy diet and lifestyle.