Singlin - Pharmacology: Decreases blood glucose by stimulating insulin release from the pancreas.
Indication: Adjunct to diet and exercise to lower blood glucose in patients with nonî“¸insulinî“¸dependent diabetes mellitus (type 2) whose hyperglycemia cannot be controlled by diet and exercise alone. Can be used with metformin or thiazolidinediones (eg, rosiglitazone) when hyperglycemia cannot be controlled by exercise, diet, and monotherapy with metformin, sulfonylureas, repaglinide, or thiazolidinediones.
Singlin is an oral diabetes medicine that helps control blood sugar levels. This medication lowers blood sugar by causing the pancreas to produce insulin.
Singlin is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with Singlin if needed.
Singlin may also be used for purposes not listed in this medication guide.
Insulin secretion by pancreatic β cells is partly controlled by cellular membrane potential. Membrane potential is regulated through an inverse relationship between the activity of cell membrane ATP-sensitive potassium channels (ABCC8) and extracellular glucose concentrations. Extracellular glucose enters the cell via GLUT2 (SLC2A2) transporters. Once inside the cell, glucose is metabolized to produce ATP. High concentrations of ATP inhibit ATP-sensitive potassium channels causing membrane depolarization. When extracellular glucose concentrations are low, ATP-sensitive potassium channels open causing membrane repolarization. High glucose concentrations cause ATP-sensitive potassium channels to close resulting in membrane depolarization and opening of L-type calcium channels. The influx of calcium ions stimulates calcium-dependent exocytosis of insulin granules. Singlin increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner.
Singlin helps to treat diabetes by keeping your blood sugar in control. Singlin stimulates the pancreas to release insulin which helps lower the high blood sugar level that occurs after each meal. Singlin is meant to be taken as part of a complete diabetes care programme that should include exercise, a healthy diet and regular monitoring of blood sugar levels.
Oral Type 2 DM
Adult: Usual initial dose: 0.5 mg, taken within 30 minutes of main meals. Initial doses of 1 or 2 mg may be used in patients who have had previous hypoglycaemic treatment. May adjust dose at intervals of 1-2 wk, up to 4 mg before meals. Max dose: 16 mg daily. Hepatic impairment: May require longer intervals between dosage adjustments.
Indications: Type 2 DM.