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Solu-Decortin H

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Solu-Decortin H uses and description

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Solu-Decortin H - Solu-Decortin H is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Solu-Decortin H restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Solu-Decortin H contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Solu-Decortin H inhibits the activity of fibroblasts and collagen formation.

Solu-Decortin H inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.

Solu-Decortin H reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.

Solu-Decortin H inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.

Solu-Decortin H has a vasoconstrictor effect with direct application to the vessels.

Solu-Decortin H has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Solu-Decortin H enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.

Solu-Decortin H inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.

Solu-Decortin H also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Solu-Decortin H affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.

In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.

When systemic use the therapeutic activity of Solu-Decortin H is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local application the therapeutic activity of Solu-Decortin H is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

As compared with hydrocortisone the anti-inflammatory activity of Solu-Decortin H is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.

Indications: parenteral corticosteroid

OralAllergic conditions; collagen diseases (eg, systemic lupus erythematous, acute rheumatic carditis); dermatologic diseases; edematous states; endocrine conditions; GI diseases; hematologic diseases; neoplastic conditions; neoplastic diseases; nervous system conditions (eg, acute exacerbations of multiple sclerosis); ophthalmic conditions; conditions related to organ transplantation; pulmonary disease (eg, asthma); renal condition (eg, nephrotic syndrome); rheumatologic conditions; specific infectious diseases including trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concomitantly with appropriate antituberculous chemotherapy; tuberculosis with pleural or pericardial effusion. Ophthalmic Econopred Plus, Prednisol, Pred ForteTreatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Econopred Plus, PrednisolTreatment of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Pred MildTreatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).

Active ingredients: Prednisolone
Unit description, dosagePrice, USD

List of solu-decortin h brand and generic drugs

Solu-Delta-Cortef Sterile Solution
Powder for Solution; Prednisolone 21-Succinate Sodium 10 mg / ml
Powder for Solution; Prednisolone 21-Succinate Sodium 50 mg / ml
Soluble Prednisolone (United Kingdom)
Tablet; Oral; Prednisolone Sodium Phosphate 5 mg
Tablets; Oral; Prednisolone Sodium Phosphate 5 mg
Solucort
Soludacortin
Solupred (France, Tunisia)
Solution; Oral; Prednisolone Metasulfobenzoate Sodium 1 mg / ml
Tablet, Dispersible; Oral; Prednisolone Metasulfobenzoate Sodium 20 mg
Tablet, Dispersible; Oral; Prednisolone Metasulfobenzoate Sodium 5 mg
Tablet, Effervescent; Oral; Prednisolone Metasulfobenzoate Sodium 20 mg
Tablet, Effervescent; Oral; Prednisolone Metasulfobenzoate Sodium 5 mg
1 g x 1's
500 mg x 1's
Solupred 20 mg x 1 loï 20 Tablet
Solupred 1g AMP / 1
Solupred 500mg AMP / 1
Sopacortelone (Ethiopia)
Sophipren (Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama)
Suspension; Ophthalmic; Prednisolone Acetate 1%
Sophipren Ofteno
Suspension; Ophthalmic; Prednisolone Acetate 1%
Sophiren Ofteno (Colombia)
SP-Cortil (Singapore)
SP-Cortil 5 mg x 1's
SP-Cortil 3 mg/5 mL x 1's
Spalin (Taiwan)
Spalin 10 g
Spirazon (Japan)
Spiricort (Switzerland)
Tablet, Film-Coated; Oral; Prednisolone 20 mg
Tablet, Film-Coated; Oral; Prednisolone 5 mg
Tablet, Film-Coated; Oral; Prednisolone 50 mg
Tablets, Film-Coated; Oral; Prednisolone 20 mg
Tablets, Film-Coated; Oral; Prednisolone 5 mg
Tablets, Film-Coated; Oral; Prednisolone 50 mg
SPMC Prednisolone (Sri Lanka)
Steran
Sterane
Injectable; Injection; Prednisolone Acetate 25 mg / ml
Tablet; Oral; Prednisolone Acetate 5 mg
Tablets; Oral; Prednisolone Acetate 5 mg
Sterodin P
Sterodin P 5 mg Tablet$ 0.01
Sterodin PF
Sterodin PF 10 mg Tablet$ 0.03
Sterofrin
Sterosone (Vietnam)
Sterosone 5 mg x 1 chai 100 Tablet
Succimedrol
Succimedrol 40 mg Injection$ 1.74
Sunpred (Taiwan)
Sunpred 5 mg

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