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Solupred

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Solupred uses and description

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Solupred - Solupred is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Solupred restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Solupred contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Solupred inhibits the activity of fibroblasts and collagen formation.

Solupred inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.

Solupred reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.

Solupred inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.

Solupred has a vasoconstrictor effect with direct application to the vessels.

Solupred has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Solupred enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.

Solupred inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.

Solupred also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Solupred affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.

In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.

When systemic use the therapeutic activity of Solupred is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local application the therapeutic activity of Solupred is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

As compared with hydrocortisone the anti-inflammatory activity of Solupred is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.

Indications: corticosteroid

Indications: eye disorders

Solupred helps relieve inflammation and itch that may occur with certain skin problems and allergies. It is also used to relieve pain in arthritic joints, fluid retention in head injuries, treat inflammatory bowel disease and to control asthma. Solupred may also be used to prevent organ transplant rejection after a transplant. Solupred may be used for other purposes as decided by your doctor. Solupred belongs to a group of medicines called steroids.

Methylprednisolone is a synthetic glucocorticoid drug. It is sold in the USA and Canada under the brand names Medrol, Solu-Medrol and Cadista. It is also available as a generic drug.

It is a variant of prednisolone, methylated at carbon 6 of the B ring.

Active ingredients: Prednisolone
Unit description, dosagePrice, USD
Solution; Oral; Prednisolone Metasulfobenzoate Sodium 1 mg / ml
Tablet, Dispersible; Oral; Prednisolone Metasulfobenzoate Sodium 20 mg
Tablet, Dispersible; Oral; Prednisolone Metasulfobenzoate Sodium 5 mg
Tablet, Effervescent; Oral; Prednisolone Metasulfobenzoate Sodium 20 mg
Tablet, Effervescent; Oral; Prednisolone Metasulfobenzoate Sodium 5 mg
1 g x 1's
500 mg x 1's
Solupred 20 mg x 1 loï 20 Tablet
Solupred 1g AMP / 1
Solupred 500mg AMP / 1

List of solupred brand and generic drugs

Soludacortin
Sopacortelone (Ethiopia)
Sophipren (Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama)
Suspension; Ophthalmic; Prednisolone Acetate 1%
Sophipren Ofteno
Suspension; Ophthalmic; Prednisolone Acetate 1%
Sophiren Ofteno (Colombia)
SP-Cortil (Singapore)
SP-Cortil 5 mg x 1's
SP-Cortil 3 mg/5 mL x 1's
Spalin (Taiwan)
Spalin 10 g
Spirazon (Japan)
Spiricort (Switzerland)
Tablet, Film-Coated; Oral; Prednisolone 20 mg
Tablet, Film-Coated; Oral; Prednisolone 5 mg
Tablet, Film-Coated; Oral; Prednisolone 50 mg
Tablets, Film-Coated; Oral; Prednisolone 20 mg
Tablets, Film-Coated; Oral; Prednisolone 5 mg
Tablets, Film-Coated; Oral; Prednisolone 50 mg
SPMC Prednisolone (Sri Lanka)
Steran
Sterane
Injectable; Injection; Prednisolone Acetate 25 mg / ml
Tablet; Oral; Prednisolone Acetate 5 mg
Tablets; Oral; Prednisolone Acetate 5 mg
Sterodin P
Sterodin P 5 mg Tablet$ 0.01
Sterodin PF
Sterodin PF 10 mg Tablet$ 0.03
Sterofrin
Sterosone (Vietnam)
Sterosone 5 mg x 1 chai 100 Tablet
Succimedrol
Succimedrol 40 mg Injection$ 1.74
Sunpred (Taiwan)
Sunpred 5 mg
Supercortisol
Thiopred
Thiopred 5 mg Tablet$ 0.01
Tonfonrin (Taiwan)
Tonfonrin 5 mg
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortenol (Argentina, Austria, Belgium, Czech Republic, Denmark, Finland, Germany, Hungary, Iceland, Israel, Luxembourg, Netherlands, Norway, Oman, Romania, Slovakia, Sweden, Switzerland)
Drops; Ophthalmic; Prednisolone Acetate 0.5%
Gel; Ophthalmic; Prednisolone Pivalate 0.5%
Ointment; Ophthalmic; Prednisolone Pivalate 0.5%
Solution; Ophthalmic; Prednisolone Acetate 0.5%
Ultracortenol 1 loï 5 mL
Ultracortenol 1 tuyùp 5 g
Ultracortenol 5 mg/1 mL x 1 loï 5 mL

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