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Spéciorlac

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Spéciorlac uses and description

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Spéciorlac consists of Neomycin, Spiramycin.

Neomycin - Spéciorlac (Neomycin) is an antibiotic.

Spéciorlac (Neomycin) is used to reduce the risk of infection during surgery of the bowel. Spéciorlac (Neomycin) is also used to reduce the symptoms of hepatic coma.

Spéciorlac (Neomycin) may also be used for purposes other than those listed here.

Spéciorlac (Neomycin) is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

Oral Preoperative intestinal antisepsis

Adult: 1 g every hr for 4 doses then every 4 hr for 2-3 days; or 1 g at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with oral erythromycin; or 6 g/day divided every 4 hr for 2-3 days.

Child: 90 mg/kg/day divided every 4 hr for 2 days; or 25 mg/kg at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with erythromycin base. Renal impairment: Dose modification required. Oral Adjunct in hepatic encephalopathy

Adult: 4-12 g daily in divided doses for 5-7 days.

Child: 50-100 mg/kg/day in divided doses every 6-8 hr or 2.5-7 g/m 2 /day divided every 4-6 hr for 5-6 days. Max: 12 g/day. Renal impairment: Dose modification required. Oral Chronic hepatic insufficiency

Adult: 4 g/day for an indefinite period. Renal impairment: Dose modification required. Otic/Aural Otic infections

Adult: Per ml solution contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 10 mg: Instill 4 drops into the affected ear(s) 3 or 4 times daily. Treatment duration should be limited to 10 consecutive days. Ophthalmic Susceptible ophthalmic infections

Adult: Per ml solution contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and dexamethasone 1 mg: Instill 1-2 drops into the affected eye(s) 4-6 times daily, up to hrly admin in severe cases. Topical/Cutaneous Skin infections

Adult: Per g cream contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 5 mg: Apply onto affected area 2-4 times daily as needed. May gently rub cream into affected areas if conditions permit.

Child: In combination with anti-infectives: Apply ointment or cream to affected area 1-3 times/day. In combination with corticosteroids and other anti-infectives: Apply ointment or cream to affected area 2-4 times/day. As irrigation: Topical solutions of 0.1-1% have been used.

Indications:

Adult: PO Pre-op intestinal antisepsis 1 g/hr for 4 doses then 1 g 4 hrly for 2-3 days. Adjunct in hepatic encephalopathy 4-12 g/day in divided doses for 5-7 days. Chronic hepatic insufficiency 4 g/day. Ophth Susceptible ophth infections Per mL soln contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10, 000 u and dexamethasone 1 mg: Instill 1-2 drops 4-6 times/day, up to hrly in severe cases. Otic Otic infections Per mL soln contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 u and hydrocortisone acetate 10 mg: Instill 4 drops 3-4 times/day for not >10 consecutive days. Topical Skin infections Per g cream contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 u and hydrocortisone acetate 5 mg: Apply 2-4 times/day as needed.

Oral Preoperative intestinal antisepsis

Adult: 1 g every hr for 4 doses then every 4 hr for 2-3 days; or 1 g at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with oral erythromycin; or 6 g/day divided every 4 hr for 2-3 days.

Child: 90 mg/kg/day divided every 4 hr for 2 days; or 25 mg/kg at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with erythromycin base. Renal impairment: Dose modification required. Oral Adjunct in the management of hepatic encephalopathy

Adult: 4-12 g daily in divided doses for 5-7 days.

Child: 50-100 mg/kg/day in divided doses every 6-8 hr or 2.5-7 g/m 2 /day divided every 4-6 hr for 5-6 days. Max: 12 g/day. Renal impairment: Dose modification required. Oral Chronic hepatic insufficiency

Adult: 4 g/day for an indefinite period. Renal impairment: Dose modification required. Ophthalmic Susceptible ophthalmic infections

Adult: Per ml solution contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and dexamethasone 1 mg: Instill 1-2 drops into the affected eye(s) 4-6 times daily, up to hrly admin in severe cases. Otic/Aural Susceptible otic infections

Adult: Per ml solution contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 10 mg: Instill 4 drops into the affected ear(s) 3 or 4 times daily. Treatment duration should be limited to 10 consecutive days. Topical/Cutaneous Skin infections

Adult: Per g cream contains Spéciorlac (Neomycin) sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 5 mg: Apply onto affected area 2-4 times daily as needed. May gently rub cream into affected areas if conditions permit.

Child: In combination with anti-infectives: Apply ointment or cream to affected area 1-3 times/day. In combination with corticosteroids and other anti-infectives: Apply ointment or cream to affected area 2-4 times/day. As irrigation: Topical solutions of 0.1-1% have been used.

Indications: Orally used for bacterial diarrhoeas and dysentery.

Preparation of bowel before surgery.

Hepatic coma.

Topically for infected wound, ulcers, burn, external ear infections, conjunctivitis.

Spiramycin - Oral Toxoplasmosis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Protozoal infections

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Cryptosporidiosis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Susceptible infections

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Intravenous Toxoplasmosis

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Protozoal infections

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Cryptosporidiosis

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Susceptible infections

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

Indications:

Adult: PO Cryptosporidiosis; Protozoal infections; Susceptible infections; Toxoplasmosis 6-9 million u/day in 2-3 divided doses. Severe: Up to 15 million u/day in divided doses. IV Cryptosporidiosis; Cryptosporidiosis; Susceptible infections; Toxoplasmosis 1.5 million u 8 hrly. Severe: May double dose.

Oral Toxoplasmosis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Protozoal infections e.g. malaria, balantidiasis, amoebiasis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Cryptosporidiosis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Oral Susceptible infections

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.

Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid. Intravenous Toxoplasmosis

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Protozoal infections e.g. malaria, balantidiasis, amoebiasis

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Cryptosporidiosis

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections. Intravenous Susceptible infections

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

Active ingredients: Neomycin/Spiramycin
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Neomycin/Spiramycin (France)
 
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