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Streptase

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Streptase uses and description

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Streptase - Streptokinase(SK), a protein secreted by several species of streptococci can bind and activate human plasminogen. SK is used as an effective and inexpensive clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. Streptase belongs to a group of medications known as fibrinolytics, and complexes of Streptase with human plasminogen can hydrolytically activate other unbound plasminogen by activating through bond cleavage to produce plasmin. There are three domains to Streptokinase, denoted α (residues 1–150), β (residues 151–287), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently.

In Systemic Administration: Acute transmural myocardial infarction (not older than 12 hrs), with persistent ST-segment elevation or recent left bundle-branch block; deep vein thromboses (not older than 14 days); acute massive pulmonary embolism ; acute and subacute thromboses of peripheral arteries; chronic occlusive arterial diseases (not older than 6 weeks); occlusion of central retinal artery or vein (arterial occlusions not older than 6-8 hrs, venous occlusions not older than 10 days). In Local Administration: Acute myocardial infarction for re-opening of coronary vessels (not older than 12 hrs); acute, subacute and chronic thromboses as well as embolisms of peripheral venous and arterial vessels. Note: No statement on therapy outcome can be made for administration beyond the time windows indicated.

Indications: thromboembolic disorders

Acute MI, lysis of intracoronary thrombi, improvement of ventricular function, and reduction of mortality associated with acute MI (IV or intracoronary route); reduction of infarct size and CHF associated with acute MI (IV); lysis of objectively diagnosed (eg, angiography) pulmonary emboli (involving obstruction of blood flow to a lobe or multiple segments, with or without unstable hemodynamics); lysis of objectively diagnosed (eg, ascending venography), acute, extensive thrombi of the deep veins (eg, those involving the popliteal vessels); lysis of acute arterial thrombi and emboli; alternative to surgical revision for clearing totally or partially occluded arteriovenous cannulae when acceptable flow cannot be achieved.

Systemic Administration: In deep vein thromboses, lung embolism, acute myocardial infarction for re-opening of coronary vessels. In acute and subacute thromboses of peripheral arteries and chronic occlusive arterial diseases, occlusion of central retinal artery or vein. Local Administration: In acute myocardial infarction for re-opening of coronary vessels, in acute, subacute and chronic thromboses, as well as embolisms of peripheral arteries. Note: Patients with the following diseases should be excluded from therapy as, generally, no success of therapy can be expected. Systemic Administration: Deep vein thrombosis: >14 days; myocardial infarction: >12 hrs; occlusions of the central retinal vessels: Arterial occlusions >6-8 hrs and venous occlusions >10 days. Local Administration: Myocardial infarction: >12 hrs; chronic arterial occlusive diseases: Embolic occlusions >6 weeks.

Indications: Acute myocardial infarction.

Pulmonary thromboembolism.

Arteriovenous occlusions.

Active ingredients: Streptokinase
Unit description, dosagePrice, USD
Injectable; Injection; Streptokinase 250,000 IU
Injectable; Injection; Streptokinase 750,000 IU
Injectable; Injection; Streptokinase 1,500,000 IU
STREPTASE Injection / 1500000 I.U.. (1 units)$ 46.24
STREPTASE Injection / 750000 I.U.. (1 units)$ 25.83
Streptase 2.5L u VIAL / 1$ 10.07
Streptase 7.5L u VIAL / 1$ 25.83
Streptase 15L u VIAL / 1$ 46.24
2.5 L u x 1's$ 10.07
7.5 L u x 1's$ 25.83
15 L u x 1's$ 46.24
Streptase 250000 IU x 1's$ 84.00
Streptase 750000 IU x 1's
Streptase 1500000 IU x 1's$ 359.04
Streptase 1.5 MIU x 1's$ 2100.00
Streptase 1500000 IU x 1 loï
Streptase 250000 IU x 10's
Streptase 750000 IU x 10's
Streptase 1500000 IU x 10's
Streptase 2.5 million iu Injection$ 10.07
Streptase 1.5 million iu Injection$ 0.04
Streptase 0.75 million iu Injection$ 0.02

List of streptase brand and generic drugs

STREPLIFE (India)
Streplife 0.75 million iu Injection$ 0.02
Streptaza (Slovenia)
Streptckenase
Streptckenase 0.75 million iu Injection$ 0.02
Streptoken (India)
Streptoken 7.5L u VIAL / 1$ 31.30
Streptoken 15L u VIAL / 1$ 45.37
7.5 L u x 1's$ 31.30
15 L u x 1's$ 45.37
Streptoken 1500000 IU x 1 loï
Streptoken 15 lac iu Injection$ 0.04
Streptoken 0.75 million iu Injection$ 0.02
Streptokin (Philippines)
Streptokin (vial) 1500000 IU x 1's
Streptokinase (India)
Injectable; Injection; Streptokinase 0.75 MIU
Injectable; Injection; Streptokinase 1.5 MIU
STREPTOKINASE Injection / 750000 I.U.. (1 vial units)$ 23.98
STREPTOKINASE Injection / 1500000 I.U.. (1 vial units)$ 42.50
7.5 L u x 1's$ 35.19
15 L u x 1's$ 63.89
Streptokinase 7.5 L u VIAL / 1$ 35.19
Streptokinase 15 L u VIAL / 1$ 63.89
Streptokinase 0.75 million iu TTK Healthcare Injection$ 0.02
Streptokinase 1.5 million iu TTK Healthcare Injection$ 0.06
Streptokinase 1.5 million iu Injection$ 0.04
Streptokinase 0.75 million iu Injection$ 0.02
Streptokinase Clonbiotech (China)
Streptokinaza (Poland)
STREPTOKINSE
STREPTOKINSE Injection / 750000 I.U.. (1 units)$ 35.19
STREPTOKINSE Injection / 1500000 I.U.. (1 units)$ 63.89
Streptonase (India)
7.5 L u x 1's$ 32.41
15 L u x 1's
Streptonase 7.5 L u VIAL / 1$ 32.41
Streptonase 15 L u VIAL / 1
STUKINASE (India)
750000 IU x 1's
1500000 IU x 1's$ 48.15
Stukinase 750000 IU INJ / 1
Stukinase 1500000 IU INJ / 1$ 48.15
Thromboflux (India)
Injectable; Injection; Streptokinase 1.5 MIU
250000 IU x 1's
750000 IU x 1's
1500000 IU x 1's
Thromboflux 1500000 IU x 1's
Thromboflux 250000 IU INJ / 1
Thromboflux 750000 IU INJ / 1

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