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Streptokinase

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Streptokinase uses and description

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Streptokinase - Pharmacology: Converts plasminogen to the enzyme plasmin, which aids in dissolution of blood clots.

Indication: Acute MI, lysis of intracoronary thrombi, improvement of ventricular function, and reduction of mortality associated with acute MI (IV or intracoronary route); reduction of infarct size and CHF associated with acute MI (IV); lysis of objectively diagnosed (eg, angiography) pulmonary emboli (involving obstruction of blood flow to a lobe or multiple segments, with or without unstable hemodynamics); lysis of objectively diagnosed (eg, ascending venography), acute, extensive thrombi of the deep veins (eg, those involving the popliteal vessels); lysis of acute arterial thrombi and emboli; alternative to surgical revision for clearing totally or partially occluded arteriovenous cannulae when acceptable flow cannot be achieved.

Intravenous Acute myocardial infarction

Adult: 1.5 million units as a single dose infused over 1 hr immediately after onset of symptoms. Intravenous Pulmonary thromboembolism

Adult: Loading dose: 250,000 units infused over 30 min.

Maintenance: 100,000 units/hr for 24-72 hr depending on the condition to be treated. For cerebral retinal thrombosis, 12 hr may be sufficient. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Child: Loading dose: 2500-4000 units/kg over 30 min, followed by infusion of 500-1000 units/kg/hr, continued until reperfusion occurs, up to 3 days. Initial dose may be estimated by Streptokinase resistance test. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values. Intravenous Arteriovenous occlusions

Adult: Loading dose: 250,000 units infused over 30 min.

Maintenance: 100,000 units/hr for 24-72 hr depending on the condition to be treated. For cerebral retinal thrombosis, 12 hr may be sufficient. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Child: Loading dose: 2500-4000 units/kg over 30 min, followed by infusion of 500-1000 units/kg/hr, continued until reperfusion occurs, up to 3 days. Initial dose may be estimated by Streptokinase resistance test. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Indications:

Adult: IV Acute MI 1.5 million u as a single dose immediately after onset of symptoms. Pulmonary thromboembolism ; Arteriovenous occlusions Loading dose: 250,000 u via infusion.

Maintenance: 100,000 u/hr for 24-72 hr depending on the condition treated. Duration for cerebral retinal thrombosis: 12 hr. Maintain thrombin clotting time at 2-4 times normal values.

Intravenous Acute myocardial infarction

Adult: 1.5 million units as a single dose infused over 1 hr immediately after onset of symptoms. Intravenous Pulmonary thromboembolism and other arteriovenous occlusions

Adult: Loading dose: 250,000 units infused over 30 min.

Maintenance: 100,000 units/hr for 24-72 hr depending on the condition to be treated. For cerebral retinal thrombosis, 12 hr may be sufficient. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Child: Loading dose: 2500-4000 units/kg over 30 min, followed by infusion of 500-1000 units/kg/hr, continued until reperfusion occurs, up to 3 days. Initial dose may be estimated by Streptokinase resistance test. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Streptokinase(SK), a protein secreted by several species of streptococci can bind and activate human plasminogen. SK is used as an effective and inexpensive clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. Streptokinase belongs to a group of medications known as fibrinolytics, and complexes of Streptokinase with human plasminogen can hydrolytically activate other unbound plasminogen by activating through bond cleavage to produce plasmin. There are three domains to Streptokinase, denoted α (residues 1–150), β (residues 151–287), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently.

Active ingredients: Streptokinase
Unit description, dosagePrice, USD
Injectable; Injection; Streptokinase 0.75 MIU
Injectable; Injection; Streptokinase 1.5 MIU
STREPTOKINASE Injection / 750000 I.U.. (1 vial units)$ 23.98
STREPTOKINASE Injection / 1500000 I.U.. (1 vial units)$ 42.50
7.5 L u x 1's$ 35.19
15 L u x 1's$ 63.89
Streptokinase 7.5 L u VIAL / 1$ 35.19
Streptokinase 15 L u VIAL / 1$ 63.89
Streptokinase 0.75 million iu TTK Healthcare Injection$ 0.02
Streptokinase 1.5 million iu TTK Healthcare Injection$ 0.06
Streptokinase 1.5 million iu Injection$ 0.04
Streptokinase 0.75 million iu Injection$ 0.02

List of streptokinase brand and generic drugs

Streptoken (India)
Streptoken 15 lac iu Injection$ 0.04
Streptoken 0.75 million iu Injection$ 0.02
Streptokin (Philippines)
Streptokin (vial) 1500000 IU x 1's
Streptokinase Clonbiotech (China)
Streptokinaza (Poland)
STREPTOKINSE
STREPTOKINSE Injection / 750000 I.U.. (1 units)$ 35.19
STREPTOKINSE Injection / 1500000 I.U.. (1 units)$ 63.89
Streptonase (India)
7.5 L u x 1's$ 32.41
15 L u x 1's
Streptonase 7.5 L u VIAL / 1$ 32.41
Streptonase 15 L u VIAL / 1
STUKINASE (India)
750000 IU x 1's
1500000 IU x 1's$ 48.15
Stukinase 750000 IU INJ / 1
Stukinase 1500000 IU INJ / 1$ 48.15
Thromboflux (India)
Injectable; Injection; Streptokinase 1.5 MIU
250000 IU x 1's
750000 IU x 1's
1500000 IU x 1's
Thromboflux 1500000 IU x 1's
Thromboflux 250000 IU INJ / 1
Thromboflux 750000 IU INJ / 1
Thromboflux 1500000 IU INJ / 1
THROMBOSOLV (India)
THROMBOSOLV Injection / 750000 I.U.. (1 vial units)$ 27.46
THROMBOSOLV Injection / 1500000 I.U.. (1 vial units)$ 45.13
Thrombosolv 7.5L u VIAL / 1$ 27.46
Thrombosolv 15L u VIAL / 1$ 45.13
7.5 L u x 1's$ 27.46
15 L u x 1's$ 45.13
Thrombosolv 1.5 million iu Injection$ 0.04
Thrombosolv 0.75 million iu Injection$ 0.02
Unitinase (Myanmar)
Xintong (China)
Zykinase (India)
ZYKINASE Injection / 0.75 m.I.U.. (1 vial units)$ 40.34
ZYKINASE Injection / 1.5 m.I.U.. (1 vial units)$ 72.19
0.75 MIU x 1's$ 40.33
1.5 MIU x 1's$ 72.19
Zykinase 0.75 MIU VIAL / 1$ 40.33
Zykinase 1.5 MIU VIAL / 1$ 72.19
Zykinase 1.5 million iu Injection$ 0.06
Zykinase 0.75 million iu Injection$ 0.04

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