Sumetrolim - Synthetic antimicrobial drug with broad spectrum bactericidal action. Sumetrolim has a bacteriostatic action, which is associated with inhibition of recycling process of PABA and a violation dihydrofolic acid\'s synthesis in bacterial cells. Trimethoprim inhibits the enzyme that is involved in the metabolism of folic acid converting dihydrofolate to tetrahydrofolate. Thus it is blocked two successive stages of the biosynthesis of purines and therefore nucleic acids that are essential for growth and reproduction of bacteria. High concentrations created in the tissues of the lung, kidney, prostate, cerebrospinal fluid, bile, bones.
Co-trimoxazole is active against gram-positive bacteria: Staphylococcus spp. (including strains of penicillinase producing), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae; gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella spp., Yersinia spp., Vibrio cholerae, Haemophilus influenzae; anaerobic asporogenous bacteria - Bacteroides spp. Co-trimoxazole is active also against Chlamydia spp.
Pseudomonas aeruginosa, Treponema spp., Mycoplasma spp., Mycobacterium tuberculosis and also viruses and fungi are resistant to co-trimoxazole.
Sumetrolim, a synthetic antiinfective agent, is used to treat and prevent urinary tract infections, diarrhea, and, when combined with either Sumetrolim or dapsone, Pneumocystis carinii infections.
Indication: For the treatment of initial episodes of uncomplicated urinary tract infections
Sumetrolim is a combined antimicrobial preparation that contains 2 agents Sumetrolim and trimehoprim. The drug works by interferin in the synthesis of dihydrofolic acid in bacterial cells thus inhibiting protein metabolims in the bacterial cell and bacterial cell multiplication. The drug is a broad spectrum antimicrobial agent. The length of the therapeutic effect reaches 7 hours.
Indications: Urogenital infections Urethritis Cystitis Pielitis Pyelonephritis Prostatitis Gonorrhea Respiratory infections Bronchitis Pneumonia Bronchopneumonia ENT infections Middle otitis Sinusitis Laryngitis Sore throat Scarlatina Gastrointestinal infections Typhoid fever Paratyphoid Cholera Bloody flux Skin and soft tissue infections Malaria As subsidiary therapy in specific cases named by your doctor.
Indications: bacterial infections, protozoal infections