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Targin

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Targin uses and description

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Targin consists of Naloxone, Oxycodone.

Naloxone - Used for: Completely or partially reversing the effects of narcotics. It may also be used to diagnose overdose of narcotics. It may also be used for other conditions as determined by your doctor.

Targin (Naloxone) is a narcotic antagonist. It works by blocking opiate receptor sites, which reverses or prevents toxic effects of narcotic (opioid) analgesics.

Targin (Naloxone) is an special narcotic drug that reverses the effects of other narcotic medicines.

Targin (Naloxone) is used to reverse the effects of narcotic drugs used during surgery or to treat pain.

Targin (Naloxone) may also be used to treat narcotic drug overdose or to diagnose narcotic drug addiction.

Targin (Naloxone) may also be used for purposes not listed in this medication guide.

Targin (Naloxone) is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Targin (Naloxone) is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; Targin (Naloxone) does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.

Oral Opioid dependence

Adult: As hydrochloride: 200 mg to 3 g daily. Intravenous Opioid overdosage

Adult: As hydrochloride: 0.4-2 mg repeated if necessary at 2-3 min intervals. If there is no response after a total of 10 mg has been given, consider the possibility of overdosage with other drugs. Reduce dose for opioid-dependent patients: 0.1-0.2 mg. IM/SC routes may be used (at IV doses) if IV admin is not feasible.

Child: As hydrochloride: Initially 10 mcg/kg IV followed by 100 mcg/kg IV if necessary. Alternatively, 0.4-0.8 mg IM or SC, repeated as necessary, if IV admin is not feasible. Parenteral Opioid-induced depression in neonates due to obstetric analgesia

Child: As hydrochloride: 10 mcg/kg IV, IM or SC repeated at 2-3 min intervals if necessary or 60 mcg/kg as a single IM dose. Intravenous Reversal of central depression from opioid use during surgery

Adult: As hydrochloride: 100-200 mcg at intervals of 2-3 minute, titrate dose according to response while maintaining analgesia.

Child: As hydrochloride: 5-10 mcg IV at 2-3 min intervals. Reconstitution: Stable in 0.9% sodium chloride and 5% dextrose inj at 4 mcg/ml for 24 hr. Incompatibility: Preparations containing bisulfite, metabisulfite, long-chain or high-molecular wt anions, or solutions with an alkaline pH.

Oral Opioid dependence

Adult: As hydrochloride: 200 mg to 3 g daily. Intravenous Opioid overdosage

Adult: As hydrochloride: 0.4-2 mg repeated if necessary at 2-3 min intervals. If there is no response after a total of 10 mg has been given, consider the possibility of overdosage with other drugs. Reduce dose for opioid-dependent patients: 0.1-0.2 mg. IM/SC routes may be used (at IV doses) if IV admin is not feasible.

Child: As hydrochloride: Initially 10 mcg/kg IV followed by 100 mcg/kg IV if necessary. Alternatively, 0.4-0.8 mg IM or SC, repeated as necessary, if IV admin is not feasible. Intravenous Reversal of central depression from opioid use during surgery

Adult: As hydrochloride: 100-200 mcg at intervals of 2-3 minute, titrate dose according to response while maintaining analgesia.

Child: As hydrochloride: 5-10 mcg IV at 2-3 min intervals. Parenteral Opioid-induced depression in neonates due to obstetric analgesia

Child: As hydrochloride: 10 mcg/kg IV, IM or SC repeated at 2-3 min intervals if necessary or 60 mcg/kg as a single IM dose. Reconstitution: Stable in 0.9% sodium chloride and 5% dextrose inj at 4 mcg/ml for 24 hr. Incompatibility: Preparations containing bisulfite, metabisulfite, long-chain or high-molecular wt anions, or solutions with an alkaline pH.

Oxycodone - Used for: Treating moderate to severe pain. It may be used before surgery to sedate the patient and reduce fear. It may also be used for other conditions as determined by your doctor.

Targin (Oxycodone) is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, respiratory and circulatory systems) at higher doses.

Targin (Oxycodone), a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Targin (Oxycodone) is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.

Oral Analgesia

Adult: Initially, 5 mg every 4-6 hr increased according to individual requirements. Extended-release preparation should be taken 12 hrly. Usual max dose 400 mg daily. Renal impairment: Starting dose of 2.5 mg every 6 hr in mild to moderate renal impairment. Hepatic impairment: Starting dose of 2.5 mg every 6 hr in mild hepatic impairment. Intravenous Analgesia

Adult: As inj: 1-10 mg over 1-2 min every 4 hr if required. As IV infusion: starting dose of 2 mg/hr increased as necessary. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully. Subcutaneous Analgesia

Adult: As inj: Initially, 5 mg every 4 hr if required or as infusion: 7.5 mg/24 hr, adjusted according to response. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully. Rectal Analgesia

Adult: As pectinate: 30 mg suppository every 6-8 hr. As hydrochloride: 10-40 mg suppository every 6-8 hr. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully.

Indications: Analgesia.

Oral Analgesia

Adult: Initially, 5 mg every 4-6 hr increased according to individual requirements. Extended-release preparation should be taken 12 hrly. Usual max dose 400 mg daily. Renal impairment: Starting dose of 2.5 mg every 6 hr in mild to moderate renal impairment. Hepatic impairment: Starting dose of 2.5 mg every 6 hr in mild hepatic impairment. Intravenous Analgesia

Adult: As inj: 1-10 mg over 1-2 min every 4 hr if required. As IV infusion: starting dose of 2 mg/hr increased as necessary. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully. Subcutaneous Analgesia

Adult: As inj: Initially, 5 mg every 4 hr if required or as infusion: 7.5 mg/24 hr, adjusted according to response. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully. Rectal Analgesia

Adult: As pectinate: 30 mg suppository every 6-8 hr. As hydrochloride: 10-40 mg suppository every 6-8 hr. Renal impairment: Initiate at a third or half of usual dose and titrate carefully. Hepatic impairment: Initiate at a third or half of usual dose and titrate carefully. Special Populations: Mild hepatic impairment and mild to moderate renal impairment: 2.5 mg every 6 hrs.

Active ingredients: Naloxone/Oxycodone
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List of targin brand and generic drugs

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