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Tenprolide

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Tenprolide uses and description

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Tenprolide - Tenprolide is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.

Tenprolide is used to treat schizophrenia in adults and children who are at least 13 years old.

Tenprolide is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Tenprolide is also used together with antidepressant medications to treat major depressive disorder in adults.

Extended-release Tenprolide (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

Tenprolide may also be used for purposes not listed in this medication guide.

Tenprolide is an antipsychotic (neuroleptic) drug. This medication exhibits a high affinity for serotonin 5HT2-receptors compared with dopamine D1- and D2-receptors in the brain. Also Tenprolide has a high affinity for histamine and alpha1-receptors and a less pronounced - to the alpha2-receptors. This drug has no affinity for the m-cholinergic receptors and benzodiazepine receptors.

Tenprolide in the dose effectively blocking dopamine D2-receptors causing only weak catalepsy. Tenprolide selectively reduces the activity of mesolimbic dopamine neurons in A10-compared with A9-nigrostriatalnymi neurons involved in motor function. This medicine does not cause long raise prolactin levels.

In accordance with the results of positron emission tomography effect of Tenprolide on serotonin 5HT2- and dopamine D2-receptors can be extended to 12 h.

Tenprolide is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Tenprolide is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Tenprolide has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of Tenprolide may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine\'s antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.

Tenprolide is used to treat schizophrenia and bipolar disorder (manic-depressive disorder). It helps to relieve symptoms common in schizophrenia and bipolar disorder, such as distorted thinking and emotional instability. Tenprolide is also used together with other medicines to treat depression.

Oral Schizophrenia

Adult: Initially, 25 mg bid on day 1, increased to 50 mg bid on day 2, 100 mg bid on day 3 and 150 mg bid on day 4. Usual dose range: 300-450 mg daily. Max: 750 mg/day.

Elderly: Initially, 25 mg daily, increased in steps of 25-50 mg daily according to response. Renal impairment: Initially, 25 mg daily, may increase in steps of 25-50 mg daily according to response. Hepatic impairment: Dose adjustment may be required. Oral Bipolar disorder

Adult: Manic phase: 50 mg bid on day 1, 100 mg bid on day 2, 150 mg bid on day 3 and 200 mg bid on day 4. Usual range: 400-800 mg/day; adjust dose according to response. Dosage increments should be ≤200 mg/day. Depressive phase: Initially, 50 mg at bedtime on day 1; 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. May increase to 400 mg on day 5 and 600 mg on day 8, if needed.

Elderly: Initially, 25 mg daily, increased in steps of 25-50 mg daily according to response. Renal impairment: Initially, 25 mg daily, may increase in steps of 25-50 mg daily according to response. Hepatic impairment: Dose adjustment may be required.

Oral Schizophrenia

Adult: Initially, 25 mg bid on day 1, increased to 50 mg bid on day 2, 100 mg bid on day 3 and 150 mg bid on day 4. Usual dose range: 300-450 mg daily. Max: 750 mg/day.

Elderly: Initially, 25 mg daily, increased in steps of 25-50 mg daily according to response. Renal impairment: Initially, 25 mg daily, may increase in steps of 25-50 mg daily according to response. Hepatic impairment: Dose adjustment may be required. Oral Bipolar disorder

Adult: Manic phase: 50 mg bid on day 1, 100 mg bid on day 2, 150 mg bid on day 3 and 200 mg bid on day 4. Usual range: 400-800 mg/day; adjust dose according to response. Dosage increments should be ≤200 mg/day. Depressive phase: Initially, 50 mg at bedtime on day 1; 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. May increase to 400 mg on day 5 and 600 mg on day 8, if needed.

Elderly: Initially, 25 mg daily, increased in steps of 25-50 mg daily according to response. Renal impairment: Initially, 25 mg daily, may increase in steps of 25-50 mg daily according to response. Hepatic impairment: Dose adjustment may be required. Special Populations: Recommended dose for patients with hepatic or renal impairment: Initially, 25 mg daily increased in increments of 25-50 mg daily according to response.

Indications:

Adult: PO Schizophrenia Initial: 25 mg twice daily on day 1, increase to 50 mg twice daily on day 2, 100 mg twice daily on day 3 and 150 mg twice daily on day 4. Usual: 300-450 mg/day. Max: 750 mg/day. Bipolar disorder Manic phase: 50 mg twice daily, increase by 50 mg/dose for each subsequent day till 3rd day. Usual: 400-800 mg/day. Increase slowly if needed. Depressive phase: Initial: 50 mg at bedtime on day 1, 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. May increase to 400 mg on day 5 and 600 mg on day 8 if needed.

Active ingredients: Quetiapine
Unit description, dosagePrice, USD

List of tenprolide brand and generic drugs

Seroquin (India)
Tablets, Film-Coated; Oral; Quetiapine Fumarate 200 mg
Tablets, Film-Coated; Oral; Quetiapine Fumarate 25 mg
Tablets, Film-Coated; Oral; Quetiapine Fumarate 50 mg
Seroquin 25 mg Tablet$ 0.04
Seroquin 200 mg Tablet$ 0.15
Seroquin 100 mg Tablet$ 0.08
Seroquin 50 mg Tablet$ 0.06
Setinin (Austria, Bulgaria)
Shu Si (China)
Socalm (India)
SOCALM Capsule/ Tablet / 25mg (10 units)$ 0.42
SOCALM Capsule/ Tablet / 200mg (10 units)$ 1.57
SOCALM Capsule/ Tablet / 100mg (10 units)$ 0.83
Socalm 25mg TAB / 10$ 0.36
Socalm 100mg TAB / 10$ 0.87
Socalm 200mg TAB / 10$ 1.64
25 mg x 10's$ 0.36
100 mg x 10's$ 0.87
200 mg x 10's$ 1.64
Tablets; Oral; Quetiapine Fumarate 25 mg
Tablets; Oral; Quetiapine Fumarate 100 mg
Tablets; Oral; Quetiapine Fumarate 200 mg
Socalm 200 mg Tablet$ 0.13
Socalm 25 mg Tablet$ 0.04
Socalm 100 mg Tablet$ 0.08
Sofrel (Bulgaria, Estonia)
Stadaquel (Slovakia)
Symquel (Poland)
Teva-Quetiapine (Canada)
Tevaquel (Bulgaria)
Tiamax (Colombia)
Tiapine (Bangladesh)
Vesparax (Argentina)
Xeroquel LP (France)
Zym-Quetiapine
Tablet; Oral; Quetiapine Fumarate 100 mg
Tablet; Oral; Quetiapine Fumarate 200 mg
Tablet; Oral; Quetiapine Fumarate 25 mg
Tablet; Oral; Quetiapine Fumarate 300 mg
Tablets; Oral; Quetiapine Fumarate 100 mg
Tablets; Oral; Quetiapine Fumarate 200 mg
Tablets; Oral; Quetiapine Fumarate 25 mg
Tablets; Oral; Quetiapine Fumarate 300 mg

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