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Thalidomide

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Thalidomide uses and description

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Thalidomide - Pharmacology: Possesses immunomodulatory, anti-inflammatory, and antiangiogenic properties; mechanism of action not fully understood.

Indication: Acute treatment of cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL); maintenance therapy for prevention and suppression of cutaneous manifestations of ENL recurrence; treatment of newly diagnosed multiple myeloma in combination with dexamethasone.

Unlabeled Uses

Graft versus host disease after bone marrow transplantation; refractory multiple myeloma; primary brain tumors; appetite stimulant for cachexia in advanced cancer; aphthous ulcers; prostate cancer (in combination with docetaxel).

Thalidomide affects the immune system. It helps promote immune responses to prevent inflammation in the body.

Thalidomide is used to treat and prevent the debilitating and disfiguring skin sores caused by erythema nodosum leprosum (ENL), an inflammatory complication of leprosy. It is also used together with another medicine called dexamethasone to treat multiple myeloma (bone marrow cancer).

Thalidomide may also be used for purposes other than those listed in this medication guide.

Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is teratogenic. The enantiomers are converted to each other in vivo. That is, if a human is given D-thalidomide or L-thalidomide, both isomers can be found in the serum. Hence, administering only one enantiomer will not prevent the teratogenic effect in humans.

Oral Erythema nodosum leprosum (Type 2)

Adult: 100-300 mg once daily at bedtime, reduced gradually by 50 mg every 2-4 wk once a satisfactory reponse is achieved. Not for monotherapy if moderate or severe neuritis present. Max: 400 mg/day. Patients < 50 kg: Initially, 100 mg daily. Oral Multiple myeloma

Adult: Initial dose of 200 mg once daily, increased by 100 mg at wkly intervals according to patient tolerance. Max: 800 mg daily.

Indications:

Adult: PO Erythema nodosum leprosum (Type 2) 100-300 mg at bedtime, reduce gradually once a satisfactory reponse is achieved. Max: 400 mg/day. Multiple myeloma Initial: 200 mg once daily, increase slowly according to patient tolerance. Max: 800 mg/day.

Active ingredients: Thalidomide
Unit description, dosagePrice, USD
Thalomid 28 50 mg capsule Disp Pack$ 4372.47
Thalomid 200 mg capsule$ 277.50
Thalomid 150 mg capsule$ 260.61
Thalomid 100 mg capsule$ 243.73
Thalomid 50 mg capsule$ 150.15

List of thalidomide brand and generic drugs

Thado (Taiwan)
Thado 50 mg x 60's
Thaled (Japan)
Thalide
Thalide 50mg CAP / 10
Thalide 100mg CAP / 10
Thalide 200mg CAP / 10
Thalidokem (Peru)
Thalidomide Celgene (Austria, Germany, Sweden)
Thalidomide Celgene 50 mg x 28's
Thalidomide Laphal
Capsule; Oral; Thalidomide 50 mg
Capsule; Oral; Thalidomide 100 mg
Thalidomide Pharmion (Australia, Austria, Denmark, Ireland, Israel, New Zealand, Norway, South Africa, United Kingdom)
Capsule; Oral; Thalidomide 50 mg
Thalidomide Pharmion Hard
Capsule; Oral; Thalidomide 50 mg
Thalimax
Thalimax 50mg CAP / 10
Thalimax 100mg CAP / 10
Thalimyde (India)
Thalin
Thalinette
Thalix (India)
Thalix 50 mg x 150's
Thalix 100 mg x 150's
Thalix 50mg CAP / 10$ 8.68
Thalix 100mg CAP / 10$ 23.11
Thalix 100 mg Capsule$ 1.48
Thalix 50 mg Capsule$ 0.83
Thaloda
Thaloda 50mg CAP / 10$ 6.17
Thaloda 100mg CAP / 10$ 10.83
Thaloda 50 mg Capsule$ 0.62
Thaloda 100 mg Capsule$ 1.08
Thaloma
Thaloma 100mg CAP / 10
Thalomide
Thalon
Thalon 100mg TAB / 10$ 12.52
Thalon 100 mg Tablet$ 1.25
Theophilcholine
Thycad (India)
Thycad 50mg CAP / 10$ 6.48
Thycad 100mg CAP / 10
50 mg x 10's$ 6.48
100 mg x 10's
Thycad 50 mg Capsule$ 0.65
Tolimid
Tolimid 50 mg Capsule$ 0.83
Tolimid 100 mg Capsule$ 1.48
Valgis
Valgraine
Yodomin

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