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Trazil Ofteno

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Trazil Ofteno uses and description

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Trazil Ofteno - Pharmacology: Inhibits bacterial protein synthesis, causing cell death.

Indication: Treatment of serious infections caused by susceptible strains of gram-negative bacteria; treatment of serious susceptible staphylococcal infections when other, less toxic drugs are contraindicated.

Ophthalmic

Treatment of superficial ocular infections.

Inhalation

Management of cystic fibrosis patients with Pseudomonas aeruginosa.

Trazil Ofteno, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections. It acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, progressive disruption of the cell envelope, and eventual cell death. Trazil Ofteno has in vitro activity against a wide range of gram-negative organisms including Pseudomonas aeruginosa.

Parenteral Susceptible infections

Adult: 3-5 mg/kg/day, to be given in 3-4 divided doses for 7-10 days. Dose may be given via IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 minutes.

Child: IM/IV infusion over 20-60 min: 6-7.5 mg/kg daily in 3-4 divided doses; premature and full-term neonates: 2 mg/kg bid. Treatment is given for 7-10 days. Renal impairment: Initial loading dose of 1 mg/kg, subsequent dosage or frequency of admin adjusted based on serum concentration. Parenteral Mild to moderate urinary tract infections

Adult: 2-3 mg/kg once daily for 7-10 days. Dose to be given via IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 minutes. Renal impairment: Initial loading dose of 1 mg/kg, subsequent dosage or frequency of admin adjusted based on serum concentration. Inhalation Cystic fibrosis

Adult: 300 mg every 12 hr inhaled from a suitable nebuliser for 28 days, then stop for 28 days and repeat in cycles of 28 days as needed. Do not give doses <6 hr apart. Ophthalmic Ocular infections

Adult: As 0.3% eye drop: Mild to moderate infections: Instill 1-2 drops into affected eye every 4 hr. Severe infections: Instill 2 drops into affected eye every 30-60 minutes initially until improvement, reduce treatment frequency before discontinuation. As 0.3% eye ointment: Mild to moderate infections: Apply a half-inch ribbon bid-tid into affected eye. Severe infections: Apply a half-inch ribbon into the affected eye every 3-4 hr until improvement, reduce treatment frequency before discontinuation. Incompatibility: Inactivated by β-lactam-type antibiotics (e.g. penicillins or cephalosporins).

Parenteral Susceptible infections

Adult: 3-5 mg/kg/day or up to 8-10 mg/kg/day in cystic fibrosis, to be given in 3-4 divided doses for 7-10 days. Dose may be given via IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 minutes.

Child: IM/IV infusion over 20-60 min: 6-7.5 mg/kg daily in 3-4 divided doses; premature and full-term neonates: 2 mg/kg bid. Treatment is given for 7-10 days. Renal impairment: Initial loading dose of 1 mg/kg, subsequent dosage or frequency of admin adjusted based on serum concentration. Parenteral Pseudomonal infections

Adult: 3-5 mg/kg/day or up to 8-10 mg/kg/day in cystic fibrosis, to be given in 3-4 divided doses for 7-10 days. Dose may be given via IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 minutes.

Child: IM/IV infusion over 20-60 min: 6-7.5 mg/kg daily in 3-4 divided doses; premature and full-term neonates: 2 mg/kg bid. Treatment is given for 7-10 days. Renal impairment: Initial loading dose of 1 mg/kg, subsequent dosage or frequency of admin adjusted based on serum concentration. Parenteral Mild to moderate urinary tract infections

Adult: 2-3 mg/kg once daily. Dose to be given via IM/IV infusion in 50-100 ml of 0.9% sodium chloride or 5% glucose over 20-60 minutes. Renal impairment: Initial loading dose of 1 mg/kg, subsequent dosage or frequency of admin adjusted based on serum concentration. Ophthalmic Eye infections

Adult: As 0.3% eye drop: Mild to moderate infections: Instill 1-2 drops into affected eye every 4 hr. Severe infections: Instill 2 drops into affected eye hrly until improvement, following which treatment should be reduced before discontinuation. As 0.3% eye ointment: Mild to moderate infections: Apply a half-inch ribbon bid-tid into affected eye. Severe infections: Apply a half-inch ribbon into the affected eye every 3-4 hr until improvement, following which treatment should be reduced before discontinuation. Inhalation Pseudomonas aeruginosa infections in patients with cystic fibrosis

Adult: 300 mg every 12 hr inhaled from a suitable nebuliser for 28 days. Stop for 28 days and repeat as needed. Incompatibility: Inactivated by β-lactam-type antibiotics (e.g. penicillins or cephalosporins).

Indications:

Adult: IV/IM Susceptible infections 3-5 mg/kg/day in 3-4 divided doses for 7-10 days. Mild to moderate UTI 2-3 mg/kg once daily for 7-10 days. Ophth Eye infections As 0.3% soln: Instill 1-2 drops 4 hrly; Severe: Instill 2 drops hrly until improvement, after which reduce dose before discontinuation. As 0.3% oint: Apply half-inch ribbon 2-3 times/day; Severe: Apply half-inch ribbon 3-4 hrly till improvement, after which reduce dose before discontinuation. Inhalation Cystic fibrosis 300 mg 12 hrly for 28 days, then stop for 28 days and repeat in cycles of 28 days as needed. Do not give doses <6 hr apart.

Indications: It should be used only as a reserve alternative to gentamycin.

Infections caused by Pseudomonas and Proteus.

Active ingredients: Tobramycin
Unit description, dosagePrice, USD
Solution; Ophthalmic; Tobramycin Sulfate 0.3%

List of trazil ofteno brand and generic drugs

Torus
Torus 80 mg Injection$ 0.83
Torvis
Torvis E/E 10 ml Drop$ 0.50
TOSANA (India)
80 mg x 80mg$ 0.92
Tosana 80mg INJ / 80mg$ 0.92
Tovix (Vietnam)
Tovix 15 mg x 1 chai 5 mL
Tozen (India)
Tozen 0.3% EYE-DPS / 5ml$ 0.44
0.3 % x 5ml$ 0.44
Tozen Eye 5 ml Drop$ 0.44
Tozen F
Tozen F Eye 5 ml Drop$ 0.17
Trazil (Colombia, Costa Rica, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama)
Ointment; Ophthalmic; Tobramycin Sulfate 0.3%
Solution; Ophthalmic; Tobramycin Sulfate 0.3%
Trazil Ungena
Ointment; Ophthalmic; Tobramycin Sulfate 0.3%
TROMACYN (India)
0.3 % x 5ml$ 0.46
0.3 % x 3.5g$ 0.38
Tromacyn Eye 5 ml Drop$ 0.44
Tromacyn Eye 3.5 gm Ointment$ 0.38
Tromacyn 0.3% EYE-DPS / 5ml$ 0.46
Tromacyn 0.3% EYE-OINT / 3.5g$ 0.38
Trona (Vietnam)
Trona 1 loï 5 mL
Trona 300 mg/100 mL x 1 loï 5 mL
Tronamycin (South Korea)
Tronanmycin (Vietnam)
Tronanmycin 40 mg/1 mL x 5 loï
Tuberbut (Argentina)
Injectable; Injection; Tobramycin 60 mg / ml
Tuo Xin (China)
Turbo
Turbo 80 mg Injection$ 0.78
Tycin
Tycin 80 mg Injection$ 0.96
Tycin Eye 5 ml Drop$ 0.46
Union Tobracin (Vietnam)
Union Tobracin 80 mg/2 mL x 1 hoäp
Unitob (Peru)
Unitoba (Vietnam)
Unitoba 1 loï 5 mL
Unitoba 3 mg/1 mL x 1 loï 5 mL
Verbram (Mexico)
Solution; Ophthalmic; Tobramycin 0.3%
Vitorex OPH (Vietnam)
Vitorex OPH 3 mg/1 mL x 1 loï 5mL
Wasser Tob (Peru)
Xao (Argentina)
Xao T
Xolof (Chile)
Ointment; Ophthalmic; Tobramycin 0.3%
Solution; Ophthalmic; Tobramycin 0.3%
Xolof 200 mg Tablet$ 0.10
Zoteon
Injectable; Injection; Tobramycin 300 mg

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