URSA - Ursodiol (also known as ursodeoxycholic acid) is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Primary bile acids are produced by the liver and stored in the gall bladder. When secreted into the colon, primary bile acids can be metabolized into secondary bile acids by intestinal bacteria. Primary and secondary bile acids help the body digest fats. URSA helps regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles containing cholesterol. Because of this property, URSA is used to treat gall stones non-surgically.
Oral Dissolution of cholesterol-rich gallstones
Adult: 6-12 mg/kg daily as a single dose at bedtime or in 2-3 divided doses continued for 3-4 mth after radiological disappearance of stones. Doses may be divided unequally with a higher dose given before bedtime to counteract increase in biliary cholesterol saturation which occurs in early morning. Max: 15 mg/kg. Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution. Oral Primary biliary cirrhosis
Adult: 10-15 mg/kg daily in 2-4 divided doses. Oral Prophylaxis of gallstones in patients undergoing rapid weight loss
Adult: 300 mg bid. Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.
Oral Dissolution of cholesterol-rich gallstones
Adult: 6-12 mg/kg daily as a single dose at bedtime or in 2-3 divided doses continued for 3-4 mth after radiological disappearance of stones. Doses may be divided unequally with a higher dose given before bedtime to counteract increase in biliary cholesterol saturation which occurs in early morning. Max: 15 mg/kg. Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution. Oral Primary biliary cirrhosis
Adult: 10-15 mg/kg daily in 2-4 divided doses. Oral Prevention of gallstones in patients undergoing rapid weight loss
Adult: 300 mg bid. Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.
Indications:
Adult: PO Dissolution of cholesterol-rich gallstones 6-12 mg/kg/day as a single dose at bedtime after radiological disappearance of stones. Max: 15 mg/kg. Primary biliary cirrhosis 10-15 mg/kg/day in 2-4 divided doses. Prevention of gallstones in patients undergoing rapid wt loss 300 mg twice daily. |
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