Utrogestan - Utrogestan is a progestogen. This medication causes a transition in the endometrium of proliferative phase, called follicular hormone in the secretory phase, and after fertilization promotes its transition to a state necessary for the development of a fertilized egg. Utrogestan reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the breast. It has no androgenic activity. This drug has little effect on protein metabolism, promotes fat deposit and accumulation of glucose in the liver and reduces the reabsorption of sodium in renal tubules.
Utrogestan has a blocking effect on the secretion of hypothalamic factors LH and FSH release, inhibits the formation of the pituitary gonadotropin-releasing hormone and inhibits ovulation.
Utrogestan is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, Utrogestan levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, Utrogestan levels in the body fall, resulting in a menstrual period. Utrogestan tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Indication: For Utrogestan supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with Utrogestan deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.
Utrogestan contains the active ingredient Utrogestan that is the yellow body's hormone. Utrogestan works by causing the transition of endometrium from the proliferation phase into secretory one. After impregnation progesteron creates favorable conditions for the fertilized egg development. Utrogestan decreases the affectability and contractility of the womb and uterine tubes muscles as well as stimulates the development of the lacteal gland.
Indications: Conditions caused by insufficiency of progesterone Premenstrual stress syndrome
Utrogestan is a natural female hormone that helps to regulate menstrual periods. Utrogestan is used together with another female hormone called estrogen, as hormone replacement therapy (HRT). HRT helps to treat menopausal symptoms such as hot flushes, vaginal dryness and itch. Utrogestan is sometimes used in younger women to treat menstrual problems caused by insufficient Utrogestan in the body.
For disorders related to Utrogestan deficit. Oral Route: Menstrual irregularity due to dysovulation, premenstrual disorders, breast pain or benign breast disorders; bleeding (due to fibroma), therapy of the menopause (complement to estrogen therapy. Vaginal Route: To aid in pregnancy, particularly in the case of repeated abortion, during in vitro fertilization cycles (IVF).
Disorders related to a Utrogestan deficit. By oral route (vaginal route is recommended as an alternative if oral route is not suitable): Menstrual irregularities due to ovulation disorders or anovulation, premenstrual disorders, breast pain or benign breast disorders (mastopathies), bleeding (due to fibroma), therapy of the menopause (adjunctive use with estrogen in postmenopausal women for prevention of endometrial hyperplasia), menace of preterm delivery and can be used up to 36 week of pregnancy, threatened miscarriage or prevention of habitual miscarriage due to luteal phase deficiency up to the 12th week of pregnancy, treatment of subfertility or primary or secondary infertility related to Utrogestan insufficiency in particular in In Vitro fertilization (IVF) cycles and/or oocyte donation. For all other Utrogestan indications, the vaginal route represents an alternative to the oral route, in case of adverse events due to Utrogestan (somnolence, dizzinesss).
Utrogestan can be used in all circumstances in which the secretion of Utrogestan by the ovaries is insufficient, in particular: Premenstrual syndrome; menstrual disorders by dysovulation or anovulation ; benign mastopathy; premenopause; menopause (in association with estrogen therapy); sterility by luteal insufficiency; menace of abortion or prevention of recurrent abortions by documented luteal insufficiency.
Indications: menstrual disorders, benign breast disorders, menopausal disorders, female infertility, threatened or recurring abortion
Indications: female infertility, menopausal disorders, menstrual disorders, premature labour, recurrent and threatened miscarriage
Indications: menstrual disorders, infertility due to ovarian dysfunction, menopausal disorders
Indications: benign breast disorders, female infertility, menopausal disorders, menstrual disorders, Utrogestan deficiency
InjectionAmenorrhea and abnormal uterine bleeding caused by hormonal imbalance in the absence of organic pathology (eg, uterine cancer).GelProgesterone supplementation or replacement as part of an assisted reproductive technology (ART) treatment for infertile women with Utrogestan deficiency. CapsulesPrevention of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving conjugated estrogen tablets. Capsules and GelUse in secondary amenorrhea. Vaginal InsertSupport embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an ART treatment program for infertile women.
Utrogestan also known as P4 (pregn-4-ene-3,20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Utrogestan belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen.
Utrogestan is commonly manufactured from the yam family, Dioscorea. Dioscorea produces large amounts of a steroid called diosgenin, which can be converted into Utrogestan in the laboratory.
Indications: As contraceptive.
Hormone replacement therapy (HRT).
Dysfunctional uterine bleeding.
Suppression of postpartum lactation.