Wysolone - Wysolone is a glucocorticosteroid (GCS). This medication inhibits the function of leukocytes and tissue macrophages. Wysolone restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Wysolone contributes to the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in inflammation. This medicine decreases capillary permeability caused by histamine release. Wysolone inhibits the activity of fibroblasts and collagen formation.
Wysolone inhibits the activity of phospholipase A2 which leads to suppression of the synthesis of prostaglandins and leukotrienes. This medication inhibits the release of COX (especially COX-2), which also helps reduce the production of prostaglandins.
Wysolone reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils as a result of their displacement from the bloodstream into lymphoid tissue; suppresses the formation of antibodies.
Wysolone inhibits the release of pituitary ACTH and beta-lipotropina but it does not reduces the level of circulating beta-endorphin. This drug also inhibits the secretion of TSH and FSH.
Wysolone has a vasoconstrictor effect with direct application to the vessels.
Wysolone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. It stimulates gluconeogenesis, amino acid contributes to the capture of the liver and kidneys and increases the activity of enzymes of gluconeogenesis. In the liver, Wysolone enhances the deposition of glycogen by stimulating the activity of glikogensintetazy and synthesis of glucose from the products of protein metabolism. This medicine increases blood glucose activates the secretion of insulin.
Wysolone inhibits glucose uptake by fat cells that leads to the activation of lipolysis. However, due to an increase in insulin secretion is stimulated lipogenesis which contributes to the accumulation of fat.
Wysolone also has catabolic effects in lymphoid and connective tissue, muscle, adipose tissue, skin, bone tissue. To a lesser extent than hydrocortisone Wysolone affects the processes of water and electrolyte metabolism: promotes the excretion of potassium and calcium, delay in the body of sodium and water. Osteoporosis and Itsenko-Cushing's syndrome are the main factors limiting the long-term therapy with corticosteroids. As a result of the catabolic actions it may suppress growth in children.
In high doses prednisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. This medication stimulates the excessive production of hydrochloric acid and pepsin in the stomach which leads to the development of peptic ulcers.
When systemic use the therapeutic activity of Wysolone is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.
For external and local application the therapeutic activity of Wysolone is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.
As compared with hydrocortisone the anti-inflammatory activity of Wysolone is 4 times greater, the mineralocorticoid activity is 0.6 times smaller.
Wysolone is the active metabolite of prednisone. Wysolone is a corticosteroid drug with predominantly glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, uveitis, rheumatoid arthritis, ulcerative colitis, temporal arteritis and Crohn's disease, Bell's palsy, multiple sclerosis, cluster headaches, systemic lupus erythematosus, acute lymphoblastic leukemia and autoimmune hepatitis and dermatomyositis.
Wysolone helps relieve inflammation and itch that may occur with certain skin problems and allergies. It is also used to relieve pain in arthritic joints, fluid retention in head injuries, treat inflammatory bowel disease and to control asthma. Wysolone may also be used to prevent organ transplant rejection after a transplant. Wysolone may be used for other purposes as decided by your doctor. Wysolone belongs to a group of medicines called steroids.
Allergic conditions; collagen diseases (eg, systemic lupus erythematous, acute rheumatic carditis); dermatologic diseases; edematous states; endocrine conditions; GI diseases; hematologic diseases; neoplastic conditions; neoplastic diseases; nervous system conditions (eg, acute exacerbations of multiple sclerosis); ophthalmic conditions; conditions related to organ transplantation; pulmonary disease (eg, asthma); renal condition (eg, nephrotic syndrome); rheumatologic conditions; specific infectious diseases including trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concomitantly with appropriate antituberculous chemotherapy; tuberculosis with pleural or pericardial effusion. Treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Treatment of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Treatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).
Indications: Replacement therapy: Adrenal insufficiency.
Nonendocrine diseases: Rheumatoid arthirits.
Osteoarthritis, Acute gouty arthirits.
Collagen diseases e.
systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases.
Severe allergic reactions e.
anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases.
Autoimmune diseases e.
haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases.
Other lung diseases e.
pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth.
Infective diseases e.
severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic c