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Xoprin

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Xoprin uses and description

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Xoprin - Pharmacology: Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cell.

Indication: Short-term treatment of active duodenal ulcer; in combination with clarithromycin and amoxicillin to eradicate Helicobacter pylori ; in combination with clarithromycin to eradicate H. pylori ; short-term treatment of active benign gastric ulcer; treatment of heartburn and other symptoms associated with gastroesophageal reflux disease (GERD); short-term treatment of erosive esophagitis that has been diagnosed by endoscopy; maintenance of healing of erosive esophagitis; long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis).

Nonprescription

Treatment of frequent heartburn that occurs 2 or more times per week.

Unlabeled Uses

As alternate-day therapy in maintaining ulcer or GERD remission rates during long-term treatment after healing during a short course of therapy; treatment of GERD-related laryngitis symptoms in patients who have not responded to antireflux measures alone; treatment of GERD in infants and children; in combination with antibiotics (eg, amoxicillin, clarithromycin) for eradication of H. pylori in children; to improve enzyme absorption in cystic fibrosis patients with intestinal malabsorption.

Xoprin is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion Xoprin reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.

Xoprin has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when Xoprin used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.

Xoprin is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Xoprin belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H ATPase at the secretory surface of the gastric parietal cell. As a result, it inhibits acid secretion into the gastric lumen. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Xoprin is a gastric medicine. It is used to treat conditions caused by excessive acidity in your stomach, such as stomach ulcers and reflux disease (reflux is also known as "heartburn", in which food or acid from your stomach backs up into your mouth, leaving a sour or bitter taste). Xoprin treats these conditions by reducing the amount of acid your stomach makes. Xoprin may also be used together with other medicines to treat a specific type of gastric problem called Helicobacter pylori or H. pylori gastritis.

Oral Peptic ulcer

Adult: 20 mg daily as a single dose or 40 mg daily in severe cases. Treatment duration: Duodenal ulcers: 4 wk; gastric ulcers: 8 wk.

Maintenance: 10-20 mg once daily. Hepatic impairment: Dose reduction may be necessary. Oral NSAID-associated ulceration

Adult: 20 mg daily. Same dose may also be used for prophylaxis of ulceration in patients who require continued NSAID therapy. Hepatic impairment: Dose reduction may be necessary. Oral H.pylori infection

Adult: Dose varies with regimen. As triple therapy: 20 mg bid or 40 mg once daily; requires combination therapy with antibiotics. Therapy is given for 1 wk. Xoprin may be continued for another 4-8 wk on its own. Hepatic impairment: Dose reduction may be necesary. Oral Gastro-oesophageal reflux disease

Adult: 20 mg once daily for 4 wk, may continue for another 4-8 wk if necessary.

Maintenance: 10 mg daily.

Child: Neonate, 1 mth-2 yr: 700 mcg/kg/day, may increase up to 3 mg/kg/day, or 20 mg daily. >2 yr: <20 kg: 10 mg once daily; ≥20 kg: 20 mg daily. Doses may be doubled if necessary. Hepatic impairment: Dose reduction may be necessary. Oral Zollinger-Ellison syndrome

Adult: Initially, 60 mg once daily, adjust according to response.

Maintenance: 20-120 mg daily. Doses >80 mg are administered usually in 2 divided doses. Hepatic impairment: Dose reduction may be necessary. Oral Prophylaxis of acid aspiration during general anaesthesia

Adult: Initially, 40 mg given the evening before surgery and another 40 mg 2-6 hr before the procedure. Hepatic impairment: Dose reduction may be necessary. Oral Acid-related dyspepsia

Adult: 10 or 20 mg daily for 2-4 wk. Hepatic impairment: Dose reduction may be necessary. Oral Erosive oesophagitis

Adult: 20 mg/day for 4-8 wk. Maintenance of healing: 20 mg/day for up to 12 mth of total therapy (including treatment period). Hepatic impairment: Dose reduction may be necessary. Intravenous Reflux oesophagitis

Adult: By infusion over 20-30 minutes or slow inj over 5 minutes: 40 mg once daily until oral admin is possible. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Intravenous Gastric and duodenal ulcers

Adult: By infusion over 20-30 minutes or slow inj over 5 minutes: 40 mg once daily until oral admin is possible. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Intravenous Prophylaxis of acid aspiration during general anaesthesia

Adult: 40 mg, to be given and completed 1 hr before the surgery. May be given via inj over 5 minutes or infusion over 20-30 minutes. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Reconstitution: The solution for IV inj is obtained by adding to the vial 10 ml of the solvent provided. (No other solvent should be used). The solution should be given over a period of at least 2.5 min at a max rate of 4 ml/minute; use within 4 hr of reconstitution. The solution for IV infusion is obtained by dissolving 1 vial in 100 ml saline for infusion or 100 ml 5% dextrose for infusion. The solution should be used within 12 hr when dissolved in saline and within 6 hr when dissolved in 5% dextrose. After reconstitution, start the infusion immediately. The constituted solution should not be mixed or co-administered in the same infusion set with any other drug. Infusion should be given over a period of ≥20-30 minutes.

Oral Peptic ulcer

Adult: 20 mg daily as a single dose or 40 mg daily in severe cases. Duration of treatment: duodenal ulcers: 4 wk; gastric ulcers: 8 wk.

Maintenance: 10-20 mg once daily. Capsule/tablet should be swallowed whole; do not crush or swallow. Hepatic impairment: Dose reduction may be necessary. Oral NSAID-associated duodenal or gastric ulcer and gastroduodenal erosions

Adult: 20 mg daily. Hepatic impairment: Dose reduction may be necessary. Oral Prophylaxis in patients with history of gastroduodenal lesions

Adult: 20 mg daily. Hepatic impairment: Dose reduction may be necessary. Oral Eradication of H. pylori infection

Adult: Dose varies with regimen: 20 mg once daily or 40 mg/day as single or in 2 divided doses; requires combination therapy with antibiotics. Hepatic impairment: Dose reduction may be necesary. Oral GERD

Adult: 20 mg once daily for 4 wk, extend to 4-8 wk if necessary.

Maintenance: 10 mg daily.

Child: Neonate, 1 mth-2 yr: 700 mcg/kg/day, may increase up to 3 mg/kg/day, or 20 mg daily. >2 yr: <20 kg: 10 mg once daily; ≥20 kg: 20 mg daily. Doses may be doubled if necessary. Hepatic impairment: Dose reduction may be necessary. Oral Zollinger-Ellison syndrome

Adult: Initially, 60 mg once daily, adjust according to response.

Maintenance: 20-120 mg daily. Doses >80 mg are administered usually in 2 divided doses. Hepatic impairment: Dose reduction may be necessary. Oral Prophylaxis of acid aspiration during anaesthesia

Adult: Initially, 40 mg given the evening before surgery and another 40 mg 2-6 hr before the procedure. Hepatic impairment: Dose reduction may be necessary. Oral Acid-related dyspepsia

Adult: 10 or 20 mg daily for 2-4 wk. Hepatic impairment: Dose reduction may be necessary. Oral Erosive oesophagitis

Adult: 20 mg/day for 4-8 wk. Maintenance of healing: 20 mg/day for up to 12 mth of total therapy. Hepatic impairment: Dose reduction may be necessary. Intravenous Reflux oesophagitis

Adult: By infusion or slow inj: 40 mg once daily. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Intravenous Gastric and duodenal ulcers

Adult: By infusion or slow inj: 40 mg once daily. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Intravenous Zollinger-Ellison syndrome

Adult: By infusion or slow inj: Initial dose: 60 mg daily. Higher daily doses may be required and the dose should be adjusted individually. When doses >60 mg daily, the dose should be bid. Hepatic impairment: Dose adjustment is required; a daily dose of 10-20 mg may be sufficient. Reconstitution: The solution for IV inj is obtained by adding to the vial 10 ml of the solvent provided. (No other solvent should be used). The solution should be given over a period of at least 2.5 min at a max rate of 4 ml/minute; use within 4 hr of reconstitution. The solution for IV infusion is obtained by dissolving 1 vial in 100 ml saline for infusion or 100 ml 5% dextrose for infusion. The solution should be used within 12 hr when dissolved in saline and within 6 hr when dissolved in 5% dextrose. After reconstitution, start the infusion immediately. The constituted solution should not be mixed or co-administered in the same infusion set with any other drug. Infusion should be given over a period of ≥20-30 minutes.

Indications:

Adult: PO Peptic ulcer 20 mg once daily. Severe: 40 mg/day. Duration: Duodenal ulcers: 4 wk; Gastric ulcers: 8 wk.

Maintenance: 10-20 mg once daily. NSAID-associated ulceration 20 mg/day. Eradication of H. pylori infection Dose varies w/ regimen: 20 mg once daily or 40 mg/day in 1-2 divided doses. To use w/ antibiotics. GERD 20 mg once daily for 4 wk, may continue for another 8 wk if needed.

Maintenance: 10 mg/day. Zollinger-Ellison syndrome Initial: 60 mg once daily.

Maintenance: 20-120 mg/day. Give doses >80 mg in 2 divided doses. Prophylaxis of acid aspiration during general anesth Initial: 40 mg the evening before surgery and another 40 mg 2-6 hr pre-op. Acid-related dyspepsia 10 or 20 mg/day 2-4 wkly. Erosive oesophagitis 20 mg/day for 4-8 wk.

Maintenance: 20 mg/day for up to 12 mth of total therapy inclusive of treatment period. IV Gastric and duodenal ulcers; Reflux oesophagitis 40 mg once daily. Prophylaxis of acid aspiration during general anesth 40 mg, to be completed 1 hr before the surgery.

Indications: Duodenal and gastric ulcers, reflux or ulcerative oesophagitis.

Zollinger-Ellison syndrome.

NSAID-induced ulcers.

Active ingredients: Omeprazole
Unit description, dosagePrice, USD

List of xoprin brand and generic drugs

Xomex
Xomex 20 mg Capsule$ 0.06
YOMZOLE (India)
20 mg x 100's$ 8.33
Yomzole 20 mg Capsule$ 0.08
Yomzole 20mg CAP / 100$ 8.33
Z-Ozole
Zanocid
Zanocid 20 mg Tablet$ 0.07
Zanprol (United Kingdom)
Tablet, Gastro-Resistant; Oral; Omeprazole 10 mg
Tablets, Gastro-Resistant; Oral; Omeprazole 10 mg
Zapcer
Zapcer 20 mg Capsule$ 0.07
Zaprocid (India)
Zaprocid 20mg TAB / 10
20 mg x 10's
Zarp
Zarp 20mg CAP / 10$ 0.74
Zarp 20 mg Capsule$ 0.07
Zatrol (Chile, Peru)
Capsule, Enteric Coated; Oral; Omeprazole 20 mg
Capsules, Enteric Coated; Oral; Omeprazole 20 mg
Zecid
Zecid 20mg CAP / 10x30$ 22.22
Zecid 20 mg Capsule$ 0.07
Zecid 20mg CAP / 10$ 0.74
ZECID 20 (India)
20 mg x 300's$ 22.22
Zecid 20 20mg CAP / 300$ 22.22
Zecid20 (Thailand)
Zecid20 20 mg x 10 x 10's
Zefxon (Thailand)
Zefxon (vial) 40 mg x 1's$ 12.03
Zefxon 20 mg x 1's
Zefxon 20 mg x 14's
Zefxon 40 mg x 1's
Capsules; Oral; Omeprazole 20 mg
Injectable; Injection; Omeprazole 40 mg
Zegerid (United States)
Tablet, Chewable; Oral; Magnesium Hydroxide 700 mg; Omeprazole 20 mg; Sodium Bicarbonate 600 mg
Tablet, Chewable; Oral; Magnesium Hydroxide 700 mg; Omeprazole 40 mg; Sodium Bicarbonate 600 mg
30 capsule in 1 bottle
1 packet in 1 packet
Zeloc
Zeloc 20 mg Capsule$ 0.07
Zenocid
Zenocid 20 mg Capsule$ 0.07
Zenpro (Singapore)
Zenpro 20 mg x 14's$ 39.00
Capsules; Oral; Omeprazole 20 mg
Zep (Bangladesh, Ethiopia)
Zep 20 mg x 1 ho├Ąp
Zep E/E 5 ml Drop$ 0.07
Zep 200 mg Tablet$ 0.03
ZEPCID (India)
20 mg x 10's
Zepcid 20 mg Capsule$ 0.14
Zepcid 20mg CAP / 10
Zephrazol (Indonesia)

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