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Xylmol

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Xylmol uses and description

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Xylmol consists of Hydrocortisone acetate, lidocaine, Al acetate, Zn oxide.

Hydrocortisone acetate - variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Hydrocortisone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.

Indications: Atopic eczema.

Allergic contact dermatitis.

Lichen simplex.

Primary irritant dermatitis.

Seborrheic dermatitis.

Psoriasis of face, flexures.

Varicose eczema.

Cystic acne.

Alopecia areata.

Discoid LE.

Hypertrophied scars, keloids.

Lichen planus.

Nail disorders.

Psoriasis of palm, sole, elbow, knee.

A combination of steroid with proper antibiotic cover may also be

Used for: Impetigo, furunculosis, secondary infected dermatoses, napkin rash, otitis externa, intertriginous eruptions.

Indications: Replacement therapy: Adrenal insufficiency.

Adrenogenital syndrome.

Nonendocrine diseases: Rheumatoid arthirits.

Osteoarthritis, Acute gouty arthirits.

Collagen diseases e.

g.

systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, nephritic syndrome, glomerulonephritis and related diseases.

Severe allergic reactions e.

g.

anaphylaxis, angioneurotic edema, urticaria and serum sickness and related diseases.

Autoimmune diseases e.

g.

haemolytic anaemia, idiopathic thrombocytopenic purpura, active chronic hepatitis and related diseases.

Other lung diseases e.

g.

pulmonary edema, accelerate lung maturation and surfactant production in the foetus and prevent respiratory distress syndrome at birth.

Infective diseases e.

g.

severe forms of tuberculosis, severe lepra reaction, certain forms of bacterial meningitis and Pneumocystis carinii pneumonia with hypoxia in AIDS patients along with proper antibiotic c

lidocaine - Xylmol (lidocaine) is an antiarrhythmic agent of class IB, local anesthetic, a derivative of acetanilide. This medication has membrane stabilizing activity. Xylmol (lidocaine) causes a blockade of sodium channels of excitable membranes of neurons and the membrane of cardiomyocytes.

This drug reduces the duration of the action potential and effective refractory period in Purkinje fibers, inhibits their automaticity. In this case, Xylmol (lidocaine) inhibits electrical activity in depolarized, arrhythmogenic sites, but minimally affects the electrical activity of normal tissues. When used in the medium therapeutic doses virtually no effect on myocardial contractility and slows AV-conduction. When applied as an antiarrhythmic agent in IV injection it begin to act in 45-90 seconds, the duration of action is 10-20 minutes; for IM administration the onset of action is in 5-15 minutes, the duration - 60-90 minutes.

Xylmol (lidocaine) causes all kinds of local anesthesia: a terminal, infiltration and wires.

Xylmol (lidocaine) is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Xylmol (lidocaine) appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Xylmol (lidocaine) in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, Xylmol (lidocaine) may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.

Indications:

Adult: Mouth/Throat Surface anesth For pain: As 2% soln: 300 mg, not more often than 3 hrly. Before procedures in the mouth and throat: As 4% soln: 40-300 mg. For dentistry and otorhinolaryngology procedures: As 10% soln: 10-50 mg. For laryngotracheal anesth: As 4% soln: 160 mg as a single dose. IV Ventricular arrhythmias As HCl: In advanced cardiac life support: 1-1.5 mg/kg, repeat if needed. Max total: 3 mg/kg. In more stable patients: 50-100 mg. May repeat once or twice if needed, up to a max of 200-300 mg in 1 hr, then 1-4 mg/min via continuous infusion. Regional anesth 50-300 mg (0.5% soln w/o adrenaline). Max: 4 mg/dose. IM Ventricular arrhythmia emergency 300 mg, repeat after 60-90 mins if needed. Epidural Epidural anesth 2-3 mL soln for each dermatome to be anaesthesized. Lumbar epidural: 250-300 mg (1% soln) for analgesia and 225-300 mg (1.5% soln) or 200-300 mg (2% soln) for anesth and thoracic epidural: 200-300 mg (1% soln). In obstetric caudal analgesia, up to 300 mg (0.5 or 1% soln). For surgical caudal analgesia: 225-300 mg (1.5% soln). For continuous epidural anaesthesia, not to repeat max doses more often than 1.5 hrly. Parenteral Sympathetic nerve block As 1% soln: 50 mg for cervical block; 50-100 mg for lumbar block. Peripheral nerve block Brachial plexus block: 225-300 mg (1.5% soln). Intercostal nerve block: 30 mg (1% soln). Paracervical block: 100 mg (1% soln) on each side, repeated not more often than 1.5 hrly. Paravertebral block: 30-50 mg (1% soln). Pudendal block: 100 mg (1% soln) on each side. Retrobulbar block: 120-200 mg (4% soln). Percutaneous infiltration anesth 5-300 mg (0.5 or 1% soln). Intraspinal Spinal anesth Normal vag delivery: 50 mg (5% hyperbaric soln) or 9-15 mg (1.5% hyperbaric soln). Caesarean operation: Up to 75 mg (5% hyperbaric soln). Other surgical procedures: 75-100 mg. Ophth Pupil dilatation during phacoemulsification cataract surgery As 1% soln: (often used w/ phenylephrine and cyclopentolate): Inject into anterior chamber of the eye at the start of the procedure. Surface anesth As 4% soln w/ fluorescein : ≥1 drops if needed. Rectal Haemorrhoids ; Painful perianal conditions Apply topically or insert rectally up to 6 times/day. Urethral Surface anesth As 2% gel: Female: 60-100 mg inserted into the urethra several mins before examination. Male: 200 mg before catheterisation and 600 mg before sounding or cytoscopy. Topical Surface anesth As eutectic mixt containing Xylmol (lidocaine) base 2.5% and prilocaine base 2.5%: Apply to skin under an occlusive dressing before procedure. Avoid occlusive dressing for genital warts.

Intravenous Ventricular arrhythmias in advanced cardiac life support for cardiac arrest due to ventricular fibrillation and pulseless ventricular tachycardia

Adult: As hydrochloride: 1-1.5 mg/kg repeated as necessary. Max total: 3 mg/kg. For ventricular arrhythmias in more stable patients: Usual loading dose: 50-100 mg as an IV inj at 25-50 mg/minute, may repeat once or twice up to a max of 200-300 mg in 1 hr, followed by 1-4 mg/minute via continuous IV infusion. May need to reduce dose if the infusion is longer than 24 hr. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intravenous Intravenous regional anaesthesia

Adult: 50-300 mg (10-60 ml) of a 0.5% solution without adrenaline ; max dose: 4 mg/kg. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intramuscular Emergency treatment of ventricular arrhythmias

Adult: As hydrochloride: 300 mg injected into the deltoid muscle, repeat after 60-90 minutes if necessary. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Sympathetic nerve block

Adult: As hydrochloride: 50 mg (5 ml) of a 1% solution for cervical block or 50-100 mg (5-10 ml) of a 1% solution for lumbar block. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Percutaneous infiltration anaesthesia

Adult: As hydrochloride: 5-300 mg (1-60 ml of a 0.5% solution or 0.5-30 ml of a 1% solution). Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Peripheral nerve block

Adult: As hydrochloride: For brachial plexus block: 225-300 mg (15-20 ml) of a 1.5% solution; for intercostal nerve block: 30 mg (3 ml) of a 1% solution; for paracervical block: 100 mg (10 ml) of a 1% solution on each side, repeated not more frequently than every 90 minutes; for paravertebral block: 30-50 mg (3-5 ml) of a 1% solution; for pudendal block: 100 mg (10 ml) as a 1% solution on each side; for retrobulbar block: 120-200 mg (3-5 ml) of a 4% solution. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Rectal Haemorrhoids

Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.

Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Rectal Perianal pain and itching

Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.

Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Ophthalmic Surface anaesthesia

Adult: As hydrochloride 4 % with fluorescein: 1 or more drops as required.

Child: As hydrochloride 4 % with fluorescein : As directed by physician. Topical/Cutaneous Surface anaesthesia

Adult: As eutectic mixture containing Xylmol (lidocaine) base 2.5% and prilocaine base 2.5%: Apply cream to skin under an occlusive dressing before procedure. Use without an occlusive dressing for genital warts. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Mouth/Throat Surface anaesthesia

Adult: For pain: 300 mg (15 ml) of 2% solution rinsed and ejected for mouth and throat pain ; or gargled and swallowed if necessary for pharyngeal pain. Not to be used more frequently than every 3 hr. Max (topical oral solution): 2.4 g/day. Before bronchoscopy, bronchography, laryngoscopy, oesophagoscopy, endotracheal intubation, and biopsy in the mouth and throat: 40-300 mg (1-7.5 ml) of 4% solution. For dentistry and otorhinolaryngology procedures: 10-50 mg of 10% solution sprayed to mucous membrane. For laryngotracheal anaesthesia: 160 mg of 4% solution sprayed or instilled as a single dose into the lumen of the larynx and trachea. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Urethral Surface anaesthesia

Adult: As 2% gel: Female: 60-100 mg inserted into the urethra several minutes before examination. Male: 100-200 mg before catheterisation and 600 mg before sounding or cystoscopy. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Epidural Epidural anaesthesia

Adult: As hydrochloride: 2-3 ml solution administered for each dermatome to be anaesthesized. Recommended doses are: lumbar epidural 250-300 mg (25-30 ml of a 1% solution) for analgesia and 225-300 mg (15-20 ml of a 1.5% solution) or 200-300 mg (10-15 ml of a 2% solution) for anaesthesia; for thoracic epidural: 200-300 mg of a 1% solution. For obstetric caudal analgesia, up to 300 mg (30 ml of a 0.5% or 1% solution); for surgical caudal analgesia: 225-300 mg (15-20 ml of a 1.5% solution). For continuous epidural anaesthesia, not to repeat max doses more frequently than 1.5 hrly. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intraspinal Spinal anaesthesia

Adult: As hyperbaric solution of 1.5% or 5% Xylmol (lidocaine) in 7.5% glucose solution. Normal vaginal delivery: 50 mg (1 ml) of a 5% solution or 9-15 mg (0.6-1 ml) of a 1.5% solution. Caesarian operation: Up to 75 mg (1.5 ml) of a 5% solution. Other surgical procedures: 75-100 mg (1.5-2 ml). Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Injection Pupil dilatation during phacoemulsification cataract surgery

Adult: As a 1% ophthalmic preservative-free solution (often used in combination with phenylephrine and cyclopentolate). To be injected into the anterior chamber of the eye at the beginning of the procedure. Reconstitution: Standard diluent: 2 g/250 ml dextrose 5%. Incompatibility: Y-site incompatibility: Amphotericin B cholesteryl sulfate complex, thiopental. Syringe incompatibility: Cefazolin. Admixture incompatibility: Phenytoin, amphotericin B, dacarbazine, methohexital.

Intravenous Pulseless ventricular fibrillation or ventricular tachycardia

Adult: As hydrochloride: 1-1.5 mg/kg repeated as necessary. Max total: 3 mg/kg. For ventricular arrhythmias in more stable patients: Usual loading dose: 50-100 mg as an IV inj at 25-50 mg/minute, may repeat once or twice up to a max of 200-300 mg in 1 hr, followed by 1-4 mg/minute via continuous IV infusion. May need to reduce dose if the infusion is longer than 24 hr. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Sympathetic nerve block

Adult: As hydrochloride: 50 mg (5 ml) of a 1% solution for cervical block or 50-100 mg (5-10 ml) of a 1% solution for lumbar block. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Epidural Epidural anaesthesia

Adult: As hydrochloride: 2-3 ml solution administered for each dermatome to be anaesthesized. Recommended doses are: lumbar epidural 250-300 mg (25-30 ml of a 1% solution) for analgesia and 225-300 mg (15-20 ml of a 1.5% solution) or 200-300 mg (10-15 ml of a 2% solution) for anaesthesia ; for thoracic epidural: 200-300 mg of a 1% solution. For obstetric caudal analgesia, up to 300 mg (30 ml of a 0.5% or 1% solution); for surgical caudal analgesia: 225-300 mg (15-20 ml of a 1.5% solution). For continuous epidural anaesthesia, not to repeat max doses more frequently than 1.5 hrly. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intraspinal Spinal anaesthesia

Adult: As hyperbaric solution of 1.5% or 5% Xylmol (lidocaine) in 7.5% glucose solution. Normal vaginal delivery: 50 mg (1 ml) of a 5% solution or 9-15 mg (0.6-1 ml) of a 1.5% solution. Caesarian operation: Up to 75 mg (1.5 ml) of a 5% solution. Other surgical procedures: 75-100 mg (1.5-2 ml). Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intravenous Intravenous regional anaesthesia

Adult: 50-300 mg (10-60 ml) of a 0.5% solution without adrenaline ; max dose: 4 mg/kg. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Urethral Surface anaesthesia

Adult: As 2% gel: Female: 60-100 mg inserted into the urethra several minutes before examination. Male: 100-200 mg before catheterisation and 600 mg before sounding or cystoscopy. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Intramuscular Emergency treatment of ventricular arrhythmias

Adult: As hydrochloride: 300 mg injected into the deltoid muscle, repeat after 60-90 minutes if necessary. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Percutaneous infiltration anaesthesia

Adult: As hydrochloride: 5-300 mg (1-60 ml of a 0.5% solution or 0.5-30 ml of a 1% solution). Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Parenteral Peripheral nerve block

Adult: As hydrochloride: For brachial plexus block: 225-300 mg (15-20 ml) of a 1.5% solution; for intercostal nerve block: 30 mg (3 ml) of a 1% solution; for paracervical block: 100 mg (10 ml) of a 1% solution on each side, repeated not more frequently than every 90 minutes; for paravertebral block: 30-50 mg (3-5 ml) of a 1% solution; for pudendal block: 100 mg (10 ml) as a 1% solution on each side; for retrobulbar block: 120-200 mg (3-5 ml) of a 4% solution. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Injection Pupil dilatation during phacoemulsification cataract surgery

Adult: As a 1% ophthalmic preservative-free solution (often used in combination with phenylephrine and cyclopentolate). To be injected into the anterior chamber of the eye at the beginning of the procedure. Mouth/Throat Surface anaesthesia

Adult: For pain: 300 mg (15 ml) of 2% solution rinsed and ejected for mouth and throat pain ; or gargled and swallowed if necessary for pharyngeal pain. Not to be used more frequently than every 3 hr. Max (topical oral solution): 2.4 g/day. Before bronchoscopy, bronchography, laryngoscopy, oesophagoscopy, endotracheal intubation, and biopsy in the mouth and throat: 40-300 mg (1-7.5 ml) of 4% solution. For dentistry and otorhinolaryngology procedures: 10-50 mg of 10% solution sprayed to mucous membrane. For laryngotracheal anaesthesia: 160 mg of 4% solution sprayed or instilled as a single dose into the lumen of the larynx and trachea. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Ophthalmic Surface anaesthesia

Adult: As hydrochloride 4 % with fluorescein: 1 or more drops as required.

Child: As hydrochloride 4 % with fluorescein : As directed by physician. Topical/Cutaneous Surface anaesthesia

Adult: As eutectic mixture containing Xylmol (lidocaine) base 2.5% and prilocaine base 2.5%: Apply cream to skin under an occlusive dressing before procedure. Use without an occlusive dressing for genital warts. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Rectal Haemorrhoids

Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.

Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Rectal Perianal pain and itching

Adult: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day.

Child: ≥12 yr: Apply topically to clean, dry area or using applicator, insert rectally, up to 6 times/day. Hepatic impairment: Reduce dose by 50% in acute hepatitis and decompensated cirrhosis. Reconstitution: Standard diluent: 2 g/250 ml dextrose 5%. Incompatibility: Y-site incompatibility: Amphotericin B cholesteryl sulfate complex, thiopental. Syringe incompatibility: Cefazolin. Admixture incompatibility: Phenytoin, amphotericin B, dacarbazine, methohexital.

Xylmol (lidocaine) Milex Products causes all kinds of local anesthesia: a terminal, infiltration and wires.

Surface anaesth: In dentistry Otorhinolaryngology for maxillary sinus Paracentesis During delivery Introduction of instruments & catheters into the resp & digestive tract Laryngeal & tracheal procedures

Production of local or regional anaesth by infiltration techniques; IV regional anaesth, by peripheral nerve block techniques eg intercostal blocks; major plexus blocks eg brachial plexus blocks & by epidural & subarachnoid blocks.

Zn oxide - Indications: nappy rash, skin irritation

Active ingredients: Hydrocortisone acetate/lidocaine/Al acetate/Zn oxide
Unit description, dosagePrice, USD
Xylmol 10's
Xylmol 200's
Xylmol 15 g
Xylmol 450 g

List of xylmol brand and generic drugs

Hydrocortisone acetate/lidocaine/Al acetate/Zn oxide (Taiwan)
 
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