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Zemplar

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Zemplar uses and description

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Zemplar - Used for: Preventing and treating high levels of parathyroid hormone in certain patients with chronic kidney disease.

Zemplar is a vitamin D compound. It works by blocking the formation and release of parathyroid hormone (PTH).

Secondary hyperparathyroidism is characterized by an elevation in parathyroid hormone (PTH) associated with inadequate levels of active vitamin D hormone. The source of vitamin D in the body is from synthesis in the skin and from dietary intake. Vitamin D requires two sequential hydroxylations in the liver and the kidney to bind to and to activate the vitamin D receptor (VDR). The endogenous VDR activator, calcitriol [1,25(OH)2 D3], is a hormone that binds to VDRs that are present in the parathyroid gland, intestine, kidney, and bone to maintain parathyroid function and calcium and phosphorus homeostasis, and to VDRs found in many other tissues, including prostate, endothelium and immune cells. VDR activation is essential for the proper formation and maintenance of normal bone. In the diseased kidney, the activation of vitamin D is diminished, resulting in a rise of PTH, subsequently leading to secondary hyperparathyroidism and disturbances in the calcium and phosphorus homeostasis.1 Decreased levels of 1,25(OH)2 D3 have been observed in early stages of chronic kidney disease. The decreased levels of 1,25(OH)2 D3 and resultant elevated PTH levels, both of which often precede abnormalities in serum calcium and phosphorus, affect bone turnover rate and may result in renal osteodystrophy. An in vitro study indicates that Zemplar is not an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 or CYP3A at concentrations up to 50 nM (21 ng/mL).

Indication: For treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4

Chronic Kidney Disease Stages 3 and 4: Prevention and treatment of secondary hyperparathyroidism associated with chronic renal insufficiency (chronic kidney disease, stages 3 and 4) patients and chronic renal failure (chronic kidney disease stage 5) patients on hemodialysis (HD) or peritoneal dialysis (PD).

Capsule: Prevention and treatment of secondary hyperparathyroidism associated with chronic renal insufficiency (CKD Stages 3 and 4) patients and chronic renal failure (CKD Stage 5) patients on hemodialysis or peritoneal dialysis. Injection: Prevention and treatment of secondary hyperparathyroidism associated with chronic renal insufficiency.

Capsule: Prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) stages 3 and 4 and CKD stage 5 patients on hemodialysis (HD) or peritoneal dialysis (PD). Injection: Prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.

Indications: hyperparathyroidism

Prevention and treatment of secondary hyperparathyroidism associated with chronic CKD stage 3 and 4 (oral), and stage 5 (IV).

Active ingredients: Paricalcitol
Unit description, dosagePrice, USD
Capsule; Oral; Paricalcitol 1 mcg
Capsule; Oral; Paricalcitol 2 mcg
Capsule; Oral; Paricalcitol 4 mcg
Injectable; Injection; Paricalcitol 0.002 mg / ml
Injectable; Injection; Paricalcitol 0.005 mg / ml
Zemplar 5 mcg/1 mL x 1 mL
Zemplar 1 mcg x 30's
Zemplar 2 mcg x 30's
Zemplar 4 mcg x 30's
Zemplar 5 mcg/1 mL x 1 mL x 5's
Zemplar (amp) 5 mcg/1 mL x 1 mL x 5's

List of zemplar brand and generic drugs

Paracalcin
Paricalcitol (Australia, Austria, Colombia, Croatia (Hrvatska), Czech Republic, Denmark, Finland, Germany, Hong Kong, Hungary, Ireland, Italy, Luxembourg, Mexico, Netherlands, Norway, Oman, Poland, Portugal, Serbia, Singapore, Slovenia, Spain, Sweden, Switzerland, Taiwan, Turkey, United Kingdom, United States, Venezuela)
Zemplar 4 mcg capsule$ 37.58
Zemplar 5 mcg/ml vial$ 28.03
Zemplar 2 mcg capsule$ 18.79
Zemplar 2 mcg/ml vial$ 11.22
Zemplar 1 mcg capsule$ 9.39
Paricalcitol Sandoz (United States)
Zemplar 1 microgram capsule, soft (United Kingdom)
Zemplar 2 micrograms capsule, soft (United Kingdom)
Zemplar 4 micrograms capsule, soft (United Kingdom)
 
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