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Zinox

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Zinox uses and description

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Zinox - Pharmacology: Inhibits mucopeptide synthesis in bacterial cell wall.

Indication: Oral form

Treatment of infections of lower respiratory tract, urinary tract, skin and skin structures; treatment of uncomplicated gonorrhea, otitis media, pharyngitis, and tonsillitis caused by susceptible strains of specific microorganisms. Treatment of early Lyme disease, pharyngitis/tonsillitis, and impetigo.

Parenteral form

Treatment of infections of lower respiratory tract, urinary tract, skin and skin structures, bone and joint; preoperative prophylaxis; treatment of septicemia, gonorrhea, and meningitis caused by susceptible strains of specific microorganisms.

Zinox is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It works by fighting bacteria in your body.

Zinox is used to treat many kinds of bacterial infections, including severe or life-threatening forms.

Zinox may also be used for other purposes not listed in this medication guide.

Zinox is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Zinox is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Zinox axetil is the prodrug

Zinox is an antibiotic. It is used to treat certain bacterial infections of the nose, throat, chest, ears, skin, bladder, bones, joints and brain. Zinox is also used to treat a sexually-transmitted disease known as gonorrhoea. Zinox belongs to a group of antibiotics called the cephalosporins.

Oral Uncomplicated urinary tract infections

Adult: 125 mg bid. Oral Respiratory tract infections

Adult: 250-500 mg bid.

Child: >3 mth: 125 mg bid or 10 mg/kg bid. Max dose: 250 mg daily. Oral Uncomplicated gonorrhoea

Adult: 1 g as a single dose. 1 g oral probenecid may be given concurrently. Oral Otitis media

Child: >2 yr: 250 mg bid or 15 mg/kg bid up to 500 mg daily. Intravenous Meningitis

Adult: 3 g every 8 hr.

Child: 200-240 mg/kg/day in 3-4 divided doses, decreased to 100 mg/kg/day after 3 days or once symptoms have improved. Neonate: 100 mg/kg/day, decreased to 50 mg/kg/day when control has been achieved. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Intramuscular Gonorrhoea

Adult: 1.5 mg as a single dose divided between 2 inj sites. 1 g oral probenecid may be given concurrently. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Prophylaxis of surgical infections

Adult: 1.5 g IV before the procedure followed by 750 mg IM every 8 hr for up to 24-48 hr depending on the procedure. For total joint replacement, 1.5 g of Zinox may be mixed with methylmethacrylate cement. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Susceptible infections

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Incompatibility: Incompatible with aminoglycosides.

Oral Uncomplicated urinary tract infections

Adult: 125 mg bid. Oral Respiratory tract infections

Adult: 250-500 mg bid.

Child: >3 mth: 125 mg bid or 10 mg/kg bid. Max dose: 250 mg daily. Oral Uncomplicated gonorrhoea

Adult: 1 g as a single dose. 1 g oral probenecid may be given concurrently. Oral Otitis media

Child: >2 yr: 250 mg bid or 15 mg/kg bid up to 500 mg daily. Intravenous Meningitis due to sensitive strains of bacteria

Adult: 3 g every 8 hr.

Child: 200-240 mg/kg/day in 3-4 divided doses, decreased to 100 mg/kg/day after 3 days or once symptoms have improved. Neonate: 100 mg/kg/day, decreased to 50 mg/kg/day when control has been achieved. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Intramuscular Gonorrhoea

Adult: 1.5 mg as a single dose divided between 2 inj sites. 1 g oral probenecid may be given concurrently. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Prophylaxis for surgical infection

Adult: 1.5 g IV before the procedure followed by 750 mg IM every 8 hr for up to 24-48 hr depending on the procedure. For total joint replacement, 1.5 g of Zinox may be mixed with methylmethacrylate cement. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Bone and joint infections

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Gonorrhoea

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Lower respiratory tract infections

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Meningitis

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Otitis media

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral UTI

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Peritonitis

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Pharyngitis

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Sinusitis

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Parenteral Skin and soft tissue infections

Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.

Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) Dosage Recommendation 10-20 750 mg bid. <10 750 mg once daily. Incompatibility: Incompatible with aminoglycosides.

Indications:

Adult: PO Uncomplicated UTI 125 mg twice daily. Resp tract infections 250-500 mg twice daily. Uncomplicated gonorrhoea W/ oral probenecid: 1 g as a single dose. IV Meningitis 3 g 8 hrly. IM Gonorrhoea W/ oral probenecid: 1.5 g as a single dose. IV/IM Surgical prophylaxis 1.5 g IV per-op, then 750 mg IM 8 hrly for up to 24-48 hr. Susceptible infections 750 mg 8 hrly, up to 1.5 g 6-8 hrly for severe infections.

Indications: Respiratory tract infections.

Uncomplicated gonorrhoea.

Otitis media.

Meningitis, Prophylaxis of surgical infections.

Susceptible infections.

Active ingredients: Cefuroxime
Unit description, dosagePrice, USD

List of zinox brand and generic drugs

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